Literature DB >> 21586929

Effect of lapatinib on hepatic parenchymal enhancement on gadoxetate disodium (EOB)-enhanced MRI scans.

Yuko Nakamura1, Shuji Date, Naoyuki Toyota, Chihiro Tani, Yukiko Honda, Daisuke Komoto, Keizo Tanitame, Kazuo Awai.   

Abstract

We present changes seen on hepatobiliary phase (HBP)-gadoxetate disodium (EOB)-enhanced magnetic resonance image of a woman with liver metastases who was treated with lapatinib. After treatment, the HBP images appeared like portal venous phase images. This suggests that lapatinib, an inhibitor of organic anion transporting polypeptide 1B1, one of the substrates of EOB, inhibits EOB uptake by hepatocytes. In patients treated with lapatinib, the ability to diagnose liver tumors on HBP images may be compromised.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21586929     DOI： 10.1097/RCT.0b013e31821a02aa

Source DB:  PubMed          Journal:  J Comput Assist Tomogr        ISSN： 0363-8715            Impact factor:   1.826


  4 in total

Review 1.  Molecular Imaging of Membrane Transporters' Activity in Cancer: a Picture is Worth a Thousand Tubes.

Authors:  Aniv Mann; Inessa Semenenko; Michal Meir; Sara Eyal
Journal:  AAPS J       Date:  2015-03-31       Impact factor: 4.009

Review 2.  Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.

Authors:  X Chu; K Korzekwa; R Elsby; K Fenner; A Galetin; Y Lai; P Matsson; A Moss; S Nagar; G R Rosania; J P F Bai; J W Polli; Y Sugiyama; K L R Brouwer
Journal:  Clin Pharmacol Ther       Date:  2013-04-10       Impact factor: 6.875

3.  Effect of lapatinib on hepatic parenchymal enhancement on gadoxetate disodium (EOB)-enhanced MRI scans of the rat liver.

Authors:  Yuko Nakamura; Yutaka Hirokawa; Shigemi Kitamura; Wataru Yamasaki; Koji Arihiro; Fuminari Tatsugami; Makoto Iida; Hideaki Kakizawa; Shuji Date; Kazuo Awai
Journal:  Jpn J Radiol       Date:  2013-04-19       Impact factor: 2.374

Review 4.  Gadoxetate-Enhanced MRI as a Diagnostic Tool in the Management of Hepatocellular Carcinoma: Report from a 2020 Asia-Pacific Multidisciplinary Expert Meeting.

Authors:  Cher Heng Tan; Shu-Cheng Chou; Nakarin Inmutto; Ke Ma; RuoFan Sheng; YingHong Shi; Zhongguo Zhou; Akira Yamada; Ryosuke Tateishi
Journal:  Korean J Radiol       Date:  2022-05-09       Impact factor: 7.109
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.