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Literature DB >> 21584810

Host-defense peptides: from biology to therapeutic strategies.

Abstract

Primitive innate defense mechanisms in the form of gene-encoded antimicrobial peptides are now considered as potential candidates for the development of new therapeutics. They are well known for their function as the first protective barrier of all organisms against microbial infections. In addition, emerging studies reveal that they assist in modulating the host immune system. The biological properties of these host-defense peptides, their role in human health, their cell selectivity and related molecular mechanisms are discussed in this multi-author review along with the strategies to transform them or their peptidomimetics into clinically usable drugs.

Entities: Disease Species

Mesh：

Substances：

Year: 2011 PMID： 21584810 DOI： 10.1007/s00018-011-0709-3

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

8 in total

1. Antimicrobial peptides of multicellular organisms.

Authors: Michael Zasloff
Journal: Nature Date: 2002-01-24 Impact factor: 49.962

Review 2. Cationic peptides: effectors in innate immunity and novel antimicrobials.

Authors: R E Hancock
Journal: Lancet Infect Dis Date: 2001-10 Impact factor: 25.071

Review 3. Antibacterial peptides: key components needed in immunity.

Authors: H G Boman
Journal: Cell Date: 1991-04-19 Impact factor: 41.582

4. Endotoxin (lipopolysaccharide) neutralization by innate immunity host-defense peptides. Peptide properties and plausible modes of action.

Authors: Yosef Rosenfeld; Niv Papo; Yechiel Shai
Journal: J Biol Chem Date: 2005-11-17 Impact factor: 5.157

Review 5. Defensins: antimicrobial peptides of innate immunity.

Authors: Tomas Ganz
Journal: Nat Rev Immunol Date: 2003-09 Impact factor: 53.106

6. Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

Authors: M Zasloff
Journal: Proc Natl Acad Sci U S A Date: 1987-08 Impact factor: 11.205

7. Sequence and specificity of two antibacterial proteins involved in insect immunity.

Authors: H Steiner; D Hultmark; A Engström; H Bennich; H G Boman
Journal: Nature Date: 1981-07-16 Impact factor: 49.962

8. Defensins. Natural peptide antibiotics of human neutrophils.

Authors: T Ganz; M E Selsted; D Szklarek; S S Harwig; K Daher; D F Bainton; R I Lehrer
Journal: J Clin Invest Date: 1985-10 Impact factor: 14.808

8 in total

18 in total

Review 1. Engineering functional epithelium for regenerative medicine and in vitro organ models: a review.

Authors: Nihal E Vrana; Philippe Lavalle; Mehmet R Dokmeci; Fariba Dehghani; Amir M Ghaemmaghami; Ali Khademhosseini
Journal: Tissue Eng Part B Rev Date: 2013-08-09 Impact factor: 6.389

2. Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2.

Authors: Jiexi Yan; Xiaolei Liang; Chang Liu; Yuemei Cheng; Lanxia Zhou; Kairong Wang; Li Zhao
Journal: Probiotics Antimicrob Proteins Date: 2018-03 Impact factor: 4.609

3. Antimicrobial action and cell agglutination by the eosinophil cationic protein are modulated by the cell wall lipopolysaccharide structure.

Authors: David Pulido; Mohammed Moussaoui; David Andreu; M Victòria Nogués; Marc Torrent; Ester Boix
Journal: Antimicrob Agents Chemother Date: 2012-02-13 Impact factor: 5.191

4. Characterization and structural analysis of hepcidin like antimicrobial peptide from Schizothorax richardsonii (Gray).

Authors: Preeti Chaturvedi; Meenakshi Dhanik; Amit Pande
Journal: Protein J Date: 2014-02 Impact factor: 2.371

5. Anti-Candida activity of 1-18 fragment of the frog skin peptide esculentin-1b: in vitro and in vivo studies in a Caenorhabditis elegans infection model.

Authors: Vincenzo Luca; Massimiliano Olivi; Antonio Di Grazia; Claudio Palleschi; Daniela Uccelletti; Maria Luisa Mangoni
Journal: Cell Mol Life Sci Date: 2013-11-10 Impact factor: 9.261

Review 6. Current and potential applications of host-defense peptides and proteins in urology.

Authors: Joey Chor Yee Lo; Dirk Lange
Journal: Biomed Res Int Date: 2015-03-01 Impact factor: 3.411

7. The Frog Skin-Derived Antimicrobial Peptide Esculentin-1a(1-21)NH2 Promotes the Migration of Human HaCaT Keratinocytes in an EGF Receptor-Dependent Manner: A Novel Promoter of Human Skin Wound Healing?

Authors: Antonio Di Grazia; Floriana Cappiello; Akiko Imanishi; Arianna Mastrofrancesco; Mauro Picardo; Ralf Paus; Maria Luisa Mangoni
Journal: PLoS One Date: 2015-06-12 Impact factor: 3.240

Review 8. Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections.

Authors: Fern Findlay; Lorna Proudfoot; Craig Stevens; Peter G Barlow
Journal: Pathog Glob Health Date: 2016-06-17 Impact factor: 2.894

Review 9. Therapy of infected wounds: overcoming clinical challenges by advanced drug delivery systems.

Authors: Pia Kaiser; Jana Wächter; Maike Windbergs
Journal: Drug Deliv Transl Res Date: 2021-02-20 Impact factor: 4.617

10. Antimicrobial peptidomimetics: reinterpreting nature to deliver innovative therapeutics.

Authors: Mariano A Scorciapino; Andrea C Rinaldi
Journal: Front Immunol Date: 2012-06-28 Impact factor: 7.561