Literature DB >> 21584809

Role of host-defence peptides in eye diseases.

Satya S Kolar1, Alison M McDermott.   

Abstract

The eye and its associated tissues including the lacrimal system and lids have evolved several defence mechanisms to prevent microbial invasion. Included among this armory are several host-defence peptides. These multifunctional molecules are being studied not only for their endogenous antimicrobial properties but also for their potential therapeutic effects. Here the current knowledge of host-defence peptide expression in the eye will be summarised. The role of these peptides in eye disease will be discussed with the primary focus being on infectious keratitis, inflammatory conditions including dry eye and wound healing. Finally the potential of using host-defence peptides and their mimetics/derivatives for the treatment and prevention of eye diseases is addressed.

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Year:  2011        PMID： 21584809      PMCID： PMC3637883          DOI： 10.1007/s00018-011-0713-7

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  143 in total

1.  Ocular surface epithelia express mRNA for human beta defensin-2.

Authors:  N A McNAMARA; R Van; O S Tuchin; S M Fleiszig
Journal:  Exp Eye Res       Date:  1999-11       Impact factor: 3.467

2.  Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea.

Authors:  A A Afonso; L Sobrin; D C Monroy; M Selzer; B Lokeshwar; S C Pflugfelder
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-10       Impact factor: 4.799

3.  Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells.

Authors:  F Niyonsaba; A Someya; M Hirata; H Ogawa; I Nagaoka
Journal:  Eur J Immunol       Date:  2001-04       Impact factor: 5.532

4.  Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction.

Authors:  J R García; F Jaumann; S Schulz; A Krause; J Rodríguez-Jiménez; U Forssmann; K Adermann; E Klüver; C Vogelmeier; D Becker; R Hedrich; W G Forssmann; R Bals
Journal:  Cell Tissue Res       Date:  2001-11       Impact factor: 5.249

5.  Multivalent Antimicrobial Peptides as Therapeutics: Design Principles and Structural Diversities.

Authors:  S P Liu; L Zhou; R Lakshminarayanan; R W Beuerman
Journal:  Int J Pept Res Ther       Date:  2010-08-26       Impact factor: 1.931

6.  Linear analogues of human beta-defensin 3: concepts for design of antimicrobial peptides with reduced cytotoxicity to mammalian cells.

Authors:  Shouping Liu; Lei Zhou; Jing Li; Anita Suresh; Chandra Verma; Yong Hwee Foo; Eric P H Yap; Donald T H Tan; Roger W Beuerman
Journal:  Chembiochem       Date:  2008-04-14       Impact factor: 3.164

7.  An angiogenic role for the human peptide antibiotic LL-37/hCAP-18.

Authors:  Rembert Koczulla; Georges von Degenfeld; Christian Kupatt; Florian Krötz; Stefan Zahler; Torsten Gloe; Katja Issbrücker; Pia Unterberger; Mohamed Zaiou; Corinna Lebherz; Alexander Karl; Philip Raake; Achim Pfosser; Peter Boekstegers; Ulrich Welsch; Pieter S Hiemstra; Claus Vogelmeier; Richard L Gallo; Matthias Clauss; Robert Bals
Journal:  J Clin Invest       Date:  2003-06       Impact factor: 14.808

8.  Fungal keratitis in far north Queensland, Australia.

Authors:  Michael R J Thew; Brian Todd
Journal:  Clin Exp Ophthalmol       Date:  2008-11       Impact factor: 4.207

9.  Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa.

Authors:  I A Maltseva; S M J Fleiszig; D J Evans; S Kerr; S S Sidhu; N A McNamara; C Basbaum
Journal:  Exp Eye Res       Date:  2007-04-14       Impact factor: 3.467

10.  The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis.

Authors:  Nadine Steubesand; Karlheinz Kiehne; Gabriele Brunke; Rene Pahl; Karina Reiss; Karl-Heinz Herzig; Sabine Schubert; Stefan Schreiber; Ulrich R Fölsch; Philip Rosenstiel; Alexander Arlt
Journal:  BMC Immunol       Date:  2009-06-12       Impact factor: 3.615
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  19 in total

Review 1.  Antimicrobial compounds in tears.

Authors:  Alison M McDermott
Journal:  Exp Eye Res       Date:  2013-07-20       Impact factor: 3.467

2.  In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis).

Authors:  Harminder S Dua; Ahmad Muneer Otri; Andrew Hopkinson; Imran Mohammed
Journal:  Trans Am Ophthalmol Soc       Date:  2014-07

3.  Therapeutic potential of the antimicrobial peptide OH-CATH30 for antibiotic-resistant Pseudomonas aeruginosa keratitis.

Authors:  Sheng-An Li; Jie Liu; Yang Xiang; Yan-Jie Wang; Wen-Hui Lee; Yun Zhang
Journal:  Antimicrob Agents Chemother       Date:  2014-03-17       Impact factor: 5.191

Review 4.  Peptide therapeutics for treating ocular surface infections.

Authors:  Curtis R Brandt
Journal:  J Ocul Pharmacol Ther       Date:  2014-09-24       Impact factor: 2.671

Review 5.  Age-related Defects in Ocular and Nasal Mucosal Immune System and the Immunopathology of Dry Eye Disease.

Authors:  Marjan Farid; Anshu Agrawal; Daniel Fremgen; Jeremiah Tao; He Chuyi; Anthony B Nesburn; Lbachir BenMohamed
Journal:  Ocul Immunol Inflamm       Date:  2014-12-23       Impact factor: 3.070

6.  Calcium regulation by thermo- and osmosensing transient receptor potential vanilloid channels (TRPVs) in human conjunctival epithelial cells.

Authors:  Stefan Mergler; Fabian Garreis; Monika Sahlmüller; Ekaterini-Maria Lyras; Peter S Reinach; Abhilash Dwarakanath; Friedrich Paulsen; Uwe Pleyer
Journal:  Histochem Cell Biol       Date:  2012-02-12       Impact factor: 4.304

Review 7.  Dry eye disease and microbial keratitis: is there a connection?

Authors:  Srihari Narayanan; Rachel L Redfern; William L Miller; Kelly K Nichols; Alison M McDermott
Journal:  Ocul Surf       Date:  2013-01-29       Impact factor: 5.033

8.  Protective role of murine β-defensins 3 and 4 and cathelin-related antimicrobial peptide in Fusarium solani keratitis.

Authors:  Satya Sree N Kolar; Hasna Baidouri; Samuel Hanlon; Alison M McDermott
Journal:  Infect Immun       Date:  2013-05-13       Impact factor: 3.441

Review 9.  Antimicrobial peptides and wound healing: biological and therapeutic considerations.

Authors:  Maria Luisa Mangoni; Alison M McDermott; Michael Zasloff
Journal:  Exp Dermatol       Date:  2016-02-10       Impact factor: 3.960

Review 10.  Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models.

Authors:  Daniela Rodrigues-Braz; Min Zhao; Nilufer Yesilirmak; Selim Aractingi; Francine Behar-Cohen; Jean-Louis Bourges
Journal:  Mol Vis       Date:  2021-05-13       Impact factor: 2.367
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