Literature DB >> 21583833

N'-[(2Z)-3-Allyl-4-oxo-1,3-thia-zolidin-2-yl-idene]-5-fluoro-3-phenyl-1H-indole-2-carbohydrazide.

Mehmet Akkurt, Selvi Karaca, Gökçe Cihan, Gültaze Capan, Orhan Büyükgüngör.   

Abstract

In the title compound, C(21)H(17)FN(4)O(2)S, the planar indole fused-ring [maximum deviation 0.009 (1) Å] makes dihedral angles of 54.75 (9) and 14.90 (9)°, respectively, with the phenyl ring and the dihydro-thia-zolyl ring. The -CH2CH=CH(2) substituent is disordered over two positions in a 0.51 (1):0.49 (1) ratio. An intra-molecular N-H⋯S hydrogen bond generates an S(5) ring motif. The two independent mol-ecules are linked into a dimer by two N-H⋯O hydrogen bonds, forming an R(2) (2)(10) ring motif. The crystal structure features inter-molecular C-H⋯π and π-π stacking [centroid-centroid distance = 3.679 (1) Å] inter-actions. C-H⋯O and C-H⋯F inter-actions are also present.

Entities:  

Year:  2009        PMID: 21583833      PMCID: PMC2977697          DOI: 10.1107/S1600536809012677

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  7 in total

1.  Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells.

Authors:  Hongyu Zhou; Shuhong Wu; Shumei Zhai; Aifeng Liu; Ying Sun; Rongshi Li; Ying Zhang; Sean Ekins; Peter W Swaan; Bingliang Fang; Bin Zhang; Bing Yan
Journal:  J Med Chem       Date:  2008-02-08       Impact factor: 7.446

2.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

3.  Synthesis, characterisation and biological activity of novel 4-thiazolidinones, 1,3,4-oxadiazoles and some related compounds.

Authors:  S Güniz Küçükgüzel; E Elçin Oruç; Sevim Rollas; Fikrettin Sahin; Ahmet Ozbek
Journal:  Eur J Med Chem       Date:  2002-03       Impact factor: 6.514

4.  5-Arylidene-2-imino-4-thiazolidinones: design and synthesis of novel anti-inflammatory agents.

Authors:  Rosaria Ottanà; Rosanna Maccari; Maria Letizia Barreca; Giuseppe Bruno; Archimede Rotondo; Antonietta Rossi; Giuseppa Chiricosta; Rosanna Di Paola; Lidia Sautebin; Salvatore Cuzzocrea; Maria Gabriella Vigorita
Journal:  Bioorg Med Chem       Date:  2005-07-01       Impact factor: 3.641

5.  Synthesis and preliminary evaluation of some pyrazine containing thiazolines and thiazolidinones as antimicrobial agents.

Authors:  Chandrakant G Bonde; Naresh J Gaikwad
Journal:  Bioorg Med Chem       Date:  2004-05-01       Impact factor: 3.641

6.  Substituted 2-imino-5-arylidenethiazolidin-4-one inhibitors of bacterial type III secretion.

Authors:  Toni Kline; Heather B Felise; Kathleen C Barry; Stona R Jackson; Hai V Nguyen; Samuel I Miller
Journal:  J Med Chem       Date:  2008-11-27       Impact factor: 7.446

7.  Synthesis and antituberculosis activity of cycloalkylidenehydrazide and 4-aza-1-thiaspiro[4.5]decan-3-one derivatives of imidazo[2,1-b]thiazole.

Authors:  Nuray Ulusoy
Journal:  Arzneimittelforschung       Date:  2002
  7 in total
  4 in total

1.  5-Fluoro-N'-[(E)-4-methoxy-benzyl-idene]-3-phenyl-1H-indole-2-carbohydrazide.

Authors:  Mehmet Akkurt; Ismail Celik; Gökçe Cihan; Gültaze Capan; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-13

2.  Methyl (2Z)-2-{(2Z)-3-[(cyclo-pentyl-idene)amino]-4-oxo-2-phenyl-imino-1,3-thia-zol-idin-5-yl-idene}acetate.

Authors:  Joel T Mague; Mehmet Akkurt; Shaaban K Mohamed; Alaa A Hassan; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-02-26

3.  5-Chloro-N'-cyclo-hexyl-idene-3-methyl-1H-indole-2-carbohydrazide.

Authors:  Mehmet Akkurt; Muhammet Zopun; Gültaze Capan; Orhan Büyükgüngör
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-06-22

4.  Synthesis and antiviral properties of novel indole-based thiosemicarbazides and 4-thiazolidinones.

Authors:  Gökçe Cihan-Üstündağ; Elif Gürsoy; Lieve Naesens; Nuray Ulusoy-Güzeldemirci; Gültaze Çapan
Journal:  Bioorg Med Chem       Date:  2015-12-08       Impact factor: 3.641

  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.