Literature DB >> 21583703

1,3-Difurfurylbenzimidazolium chloride monohydrate.

Mehmet Akkurt, Nihat Sireci, Selma Deniz, Hasan Küçükbay, Orhan Büyükgüngör.   

Abstract

The title compound, C(17)H(15)N(2)O(2) (+)·Cl(-)·H(2)O, was synthesized from benzimidazole and furfryl chloride in dimethyl-formamide. The cationic benzimidazolium ring is connected to two furan rings via methyl-ene bridges. The furan rings make dihedral angle of 79.09 (18)° with respect to each other, and make dihedral angles of 73.92 (12) and 72.58 (13)° with respect to the benzimidazole ring. O-H⋯Cl, C-H⋯O and C-H⋯Cl hydrogen bonds and C-H⋯π inter-actions contribute to the stabilization of the crystal structure. Furthermore, there is a π-π inter-action between adjacent five- and six-membered rings of the benzimidazole groups [centroid-centroid distance = 3.5305 (8) Å].

Entities:  

Year:  2009        PMID： 21583703      PMCID： PMC2977341          DOI： 10.1107/S1600536809029626

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN： 1600-5368


Related literature

For the biological activity of furan derivatives, see: Ji et al. (2009 ▶). For the anti­microbial activity of a large number of organic and organometallic derivatives of benzimidazole against standard bacterial strains, see: Küçükbay & Durmaz (1997 ▶); Küçükbay et al. (2001 ▶, 2004 ▶, 2009 ▶); Çetinkaya et al. (1996 ▶). For the catalytic activity of furans, see: Küçükbay et al. (1996 ▶). For related structures, see: Yıldırım et al. (2007 ▶); Akkurt et al. (2006 ▶, 2007 ▶). For bond-length data, see: Allen et al. (1987 ▶).

Experimental

Crystal data

C17H15N2O2 +·Cl−·H2O M = 332.78 Triclinic, a = 9.0201 (5) Å b = 9.3135 (5) Å c = 11.2711 (6) Å α = 66.778 (4)° β = 81.869 (4)° γ = 73.656 (4)° V = 834.50 (8) Å3 Z = 2 Mo Kα radiation μ = 0.25 mm−1 T = 296 K 0.58 × 0.49 × 0.38 mm

Data collection

Stoe IPDS II diffractometer Absorption correction: integration (X-RED32; Stoe & Cie, 2002 ▶) T min = 0.871, T max = 0.913 15618 measured reflections 3780 independent reflections 2972 reflections with I > 2σ(I) R int = 0.024

Refinement

R[F 2 > 2σ(F 2)] = 0.041 wR(F 2) = 0.122 S = 1.04 3780 reflections 214 parameters H atoms treated by a mixture of independent and constrained refinement Δρmax = 0.27 e Å−3 Δρmin = −0.21 e Å−3 Data collection: X-AREA (Stoe & Cie, 2002 ▶); cell refinement: X-AREA; data reduction: X-RED32 (Stoe & Cie, 2002 ▶); program(s) used to solve structure: SIR97 (Altomare et al., 1999 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997 ▶); software used to prepare material for publication: WinGX (Farrugia, 1999 ▶) and PLATON (Spek, 2009 ▶). Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536809029626/xu2569sup1.cif Structure factors: contains datablocks I. DOI: 10.1107/S1600536809029626/xu2569Isup2.hkl Additional supplementary materials: crystallographic information; 3D view; checkCIF report
C17H15N2O2+.Cl−·H2OZ = 2
Mr = 332.78F(000) = 348
Triclinic, P1Dx = 1.324 Mg m−3
Hall symbol: -P 1Mo Kα radiation, λ = 0.71073 Å
a = 9.0201 (5) ÅCell parameters from 20002 reflections
b = 9.3135 (5) Åθ = 2.0–28.0°
c = 11.2711 (6) ŵ = 0.25 mm−1
α = 66.778 (4)°T = 296 K
β = 81.869 (4)°Prism, colourless
γ = 73.656 (4)°0.58 × 0.49 × 0.38 mm
V = 834.50 (8) Å3
Stoe IPDS II diffractometer3780 independent reflections
Radiation source: sealed X-ray tube, 12 x 0.4 mm long-fine focus2972 reflections with I > 2σ(I)
plane graphiteRint = 0.024
Detector resolution: 6.67 pixels mm-1θmax = 27.5°, θmin = 2.0°
ω scansh = −11→11
Absorption correction: integration (X-RED32; Stoe & Cie, 2002)k = −12→12
Tmin = 0.871, Tmax = 0.913l = −14→14
15618 measured reflections
Refinement on F2Primary atom site location: structure-invariant direct methods
Least-squares matrix: fullSecondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.041Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.122H atoms treated by a mixture of independent and constrained refinement
S = 1.04w = 1/[σ2(Fo2) + (0.0718P)2 + 0.0531P] where P = (Fo2 + 2Fc2)/3
3780 reflections(Δ/σ)max < 0.001
214 parametersΔρmax = 0.27 e Å−3
0 restraintsΔρmin = −0.21 e Å−3
Geometry. Bond distances, angles etc. have been calculated using the rounded fractional coordinates. All su's are estimated from the variances of the (full) variance-covariance matrix. The cell e.s.d.'s are taken into account in the estimation of distances, angles and torsion angles
Refinement. Refinement on F2 for ALL reflections except those flagged by the user for potential systematic errors. Weighted R-factors wR and all goodnesses of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The observed criterion of F2 > σ(F2) is used only for calculating -R-factor-obs etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R-factors based on ALL data will be even larger.
xyzUiso*/Ueq
O10.13050 (17)−0.1335 (2)0.86538 (14)0.1035 (5)
O20.4854 (2)0.20834 (19)0.87489 (17)0.1120 (7)
N10.23659 (12)0.34379 (14)0.66557 (10)0.0532 (3)
N20.09145 (13)0.19641 (13)0.65802 (11)0.0538 (3)
C10.08420 (14)0.43162 (16)0.66979 (12)0.0494 (4)
C20.02240 (17)0.58200 (18)0.67695 (15)0.0603 (4)
C3−0.13677 (18)0.63291 (19)0.67798 (17)0.0681 (5)
C4−0.22951 (17)0.5392 (2)0.67213 (16)0.0676 (5)
C5−0.16859 (16)0.38960 (19)0.66484 (14)0.0590 (4)
C6−0.00818 (15)0.33787 (16)0.66462 (12)0.0497 (4)
C70.23474 (16)0.20505 (17)0.65930 (13)0.0558 (4)
C80.04576 (19)0.05737 (18)0.65596 (15)0.0624 (5)
C90.0118 (2)−0.05143 (19)0.78656 (15)0.0644 (5)
C10−0.1182 (3)−0.0852 (3)0.8477 (2)0.0975 (8)
C11−0.0776 (4)−0.1983 (4)0.9725 (3)0.1193 (11)
C120.0683 (4)−0.2261 (3)0.9797 (2)0.1176 (10)
C130.37621 (16)0.3936 (2)0.67077 (15)0.0617 (4)
C140.41286 (17)0.3570 (2)0.80414 (16)0.0650 (5)
C150.3759 (3)0.4445 (3)0.8759 (2)0.1043 (9)
C160.4334 (4)0.3444 (4)1.0001 (2)0.1183 (13)
C170.4990 (4)0.2065 (4)0.9964 (2)0.1177 (11)
O30.50690 (18)−0.09917 (19)0.68142 (14)0.0861 (5)
Cl10.33115 (5)−0.17640 (6)0.49633 (5)0.0794 (2)
H20.084300.644700.680800.0720*
H3−0.183700.733200.682700.0820*
H4−0.336300.579000.673200.0810*
H5−0.230600.327400.660400.0710*
H70.322400.124800.656200.0670*
H8A−0.045100.096000.604500.0750*
H8B0.12860−0.001900.615400.0750*
H10−0.21680−0.042600.814600.1170*
H11−0.14480−0.244301.037800.1430*
H120.12490−0.298501.051600.1410*
H13A0.463000.338500.630500.0740*
H13B0.360300.508700.622200.0740*
H150.322000.552400.849900.1250*
H160.424700.374001.071000.1420*
H170.548600.117801.064800.1410*
HW10.575 (3)−0.041 (3)0.627 (3)0.1190*
HW20.461 (3)−0.139 (3)0.631 (3)0.1190*
U11U22U33U12U13U23
O10.0817 (9)0.1176 (11)0.0752 (8)−0.0088 (8)−0.0101 (7)−0.0070 (8)
O20.1417 (15)0.0792 (9)0.1012 (11)−0.0119 (9)−0.0444 (10)−0.0164 (8)
N10.0444 (5)0.0560 (6)0.0524 (6)−0.0049 (4)−0.0014 (4)−0.0183 (5)
N20.0547 (6)0.0514 (6)0.0531 (6)−0.0036 (5)−0.0051 (4)−0.0227 (5)
C10.0449 (6)0.0519 (7)0.0450 (6)−0.0053 (5)−0.0021 (5)−0.0159 (5)
C20.0582 (8)0.0536 (7)0.0680 (8)−0.0090 (6)−0.0023 (6)−0.0250 (6)
C30.0610 (8)0.0584 (8)0.0812 (10)0.0015 (7)−0.0019 (7)−0.0335 (7)
C40.0483 (7)0.0708 (10)0.0785 (10)0.0008 (7)−0.0030 (7)−0.0330 (8)
C50.0484 (7)0.0665 (8)0.0624 (8)−0.0092 (6)−0.0047 (6)−0.0268 (7)
C60.0499 (6)0.0504 (7)0.0443 (6)−0.0042 (5)−0.0039 (5)−0.0178 (5)
C70.0515 (7)0.0553 (7)0.0529 (7)0.0004 (5)−0.0030 (5)−0.0212 (6)
C80.0729 (9)0.0566 (8)0.0621 (8)−0.0081 (6)−0.0080 (7)−0.0302 (6)
C90.0726 (9)0.0580 (8)0.0649 (8)−0.0120 (7)−0.0069 (7)−0.0267 (7)
C100.0818 (13)0.1172 (17)0.0885 (13)−0.0348 (12)−0.0027 (10)−0.0263 (12)
C110.124 (2)0.137 (2)0.0860 (15)−0.0649 (18)0.0070 (14)−0.0115 (14)
C120.130 (2)0.1138 (18)0.0697 (13)−0.0187 (16)−0.0097 (13)0.0007 (12)
C130.0451 (6)0.0682 (9)0.0636 (8)−0.0135 (6)0.0039 (6)−0.0184 (7)
C140.0531 (7)0.0719 (9)0.0681 (9)−0.0224 (7)−0.0034 (6)−0.0190 (7)
C150.1222 (18)0.1028 (16)0.0819 (13)0.0002 (13)−0.0143 (12)−0.0438 (12)
C160.150 (2)0.147 (3)0.0756 (13)−0.062 (2)−0.0139 (14)−0.0395 (15)
C170.147 (2)0.114 (2)0.0847 (15)−0.0519 (18)−0.0473 (15)−0.0017 (14)
O30.0829 (8)0.0841 (9)0.0778 (8)−0.0003 (6)−0.0117 (6)−0.0271 (7)
Cl10.0681 (3)0.0830 (3)0.1058 (4)−0.0237 (2)0.0067 (2)−0.0545 (3)
O1—C91.339 (2)C11—C121.276 (5)
O1—C121.382 (3)C13—C141.469 (2)
O2—C141.322 (3)C14—C151.312 (3)
O2—C171.385 (3)C15—C161.415 (3)
O3—HW10.93 (3)C16—C171.268 (5)
O3—HW20.98 (3)C2—H20.9300
N1—C11.3929 (19)C3—H30.9300
N1—C71.326 (2)C4—H40.9300
N1—C131.475 (2)C5—H50.9300
N2—C61.393 (2)C7—H70.9300
N2—C81.475 (2)C8—H8A0.9700
N2—C71.320 (2)C8—H8B0.9700
C1—C21.384 (2)C10—H100.9300
C1—C61.387 (2)C11—H110.9300
C2—C31.379 (2)C12—H120.9300
C3—C41.392 (2)C13—H13B0.9700
C4—C51.377 (3)C13—H13A0.9700
C5—C61.390 (2)C15—H150.9300
C8—C91.469 (2)C16—H160.9300
C9—C101.326 (3)C17—H170.9300
C10—C111.408 (4)
Cl1···C83.6371 (18)C5···H8A2.9500
Cl1···C13i3.6290 (19)C8···H53.0100
Cl1···O3ii3.1563 (17)C13···H23.0100
Cl1···O33.1848 (17)C14···H11ix2.9800
Cl1···C13ii3.6332 (18)C15···H16viii3.0400
Cl1···H13Aii2.6700C15···H11ix2.9900
Cl1···H8B2.6700C16···H16viii3.0200
Cl1···H13Bi2.6600HW1···Cl1ii2.27 (3)
Cl1···H8Aiii2.7500HW1···H3v2.5100
Cl1···HW22.22 (3)HW1···H72.4300
Cl1···H5iii3.0100H2···C133.0100
Cl1···HW1ii2.27 (3)H2···H13B2.5800
O1···N22.998 (2)HW2···Cl12.22 (3)
O1···C73.391 (2)HW2···H72.5300
O2···N13.123 (2)H3···O3x2.7900
O3···C17iv3.362 (3)H3···HW1x2.5100
O3···Cl13.1848 (17)H5···H8A2.5700
O3···C73.133 (2)H5···Cl1iii3.0100
O3···Cl1ii3.1563 (17)H5···C83.0100
O3···H3v2.7900H7···O32.2200
O3···H72.2200H7···HW12.4300
O3···H17iv2.7800H7···H8B2.5400
N1···N22.1772 (17)H7···H13A2.5500
N1···O23.123 (2)H7···HW22.5300
N2···O12.998 (2)H8A···C52.9500
N2···N12.1772 (17)H8A···H52.5700
C1···C6vi3.5787 (18)H8A···Cl1iii2.7500
C1···C5vi3.5392 (19)H8B···Cl12.6700
C4···C7vi3.550 (2)H8B···H72.5400
C5···C1vi3.5392 (19)H11···C14ix2.9800
C6···C1vi3.5787 (18)H11···C15ix2.9900
C7···O33.133 (2)H12···C5ix3.0200
C7···O13.391 (2)H13A···H72.5500
C7···C4vi3.550 (2)H13A···Cl1ii2.6700
C8···Cl13.6371 (18)H13B···C22.9600
C13···Cl1ii3.6332 (18)H13B···H22.5800
C13···Cl1vii3.6290 (19)H13B···Cl1vii2.6600
C16···C16viii3.435 (5)H16···C15viii3.0400
C17···O3iv3.362 (3)H16···C16viii3.0200
C2···H13B2.9600H17···O3iv2.7800
C5···H12ix3.0200
C9—O1—C12105.62 (19)O2—C17—C16109.6 (2)
C14—O2—C17106.9 (2)C1—C2—H2122.00
HW1—O3—HW2108 (3)C3—C2—H2122.00
C1—N1—C13126.21 (13)C4—C3—H3119.00
C7—N1—C13125.65 (13)C2—C3—H3119.00
C1—N1—C7108.13 (12)C5—C4—H4119.00
C6—N2—C8126.23 (13)C3—C4—H4119.00
C7—N2—C8125.52 (13)C4—C5—H5122.00
C6—N2—C7108.19 (13)C6—C5—H5122.00
N1—C1—C2131.54 (13)N1—C7—H7125.00
C2—C1—C6122.08 (13)N2—C7—H7125.00
N1—C1—C6106.38 (13)N2—C8—H8B109.00
C1—C2—C3115.74 (15)C9—C8—H8A109.00
C2—C3—C4122.20 (17)C9—C8—H8B109.00
C3—C4—C5122.28 (16)H8A—C8—H8B108.00
C4—C5—C6115.51 (15)N2—C8—H8A109.00
N2—C6—C1106.58 (12)C9—C10—H10127.00
C1—C6—C5122.18 (14)C11—C10—H10127.00
N2—C6—C5131.24 (14)C12—C11—H11126.00
N1—C7—N2110.72 (13)C10—C11—H11126.00
N2—C8—C9111.85 (13)C11—C12—H12125.00
O1—C9—C10109.98 (16)O1—C12—H12125.00
C8—C9—C10132.75 (18)N1—C13—H13A109.00
O1—C9—C8117.25 (16)C14—C13—H13A109.00
C9—C10—C11106.4 (2)C14—C13—H13B109.00
C10—C11—C12107.5 (3)N1—C13—H13B109.00
O1—C12—C11110.4 (2)H13A—C13—H13B108.00
N1—C13—C14111.84 (13)C16—C15—H15126.00
O2—C14—C15109.18 (18)C14—C15—H15126.00
C13—C14—C15131.51 (19)C15—C16—H16127.00
O2—C14—C13119.08 (17)C17—C16—H16126.00
C14—C15—C16107.3 (2)O2—C17—H17125.00
C15—C16—C17107.0 (2)C16—C17—H17125.00
C12—O1—C9—C101.9 (3)N1—C1—C6—N20.25 (14)
C9—O1—C12—C11−2.1 (3)N1—C1—C6—C5−178.98 (12)
C12—O1—C9—C8−179.56 (18)N1—C1—C2—C3179.33 (14)
C17—O2—C14—C15−2.5 (3)C2—C1—C6—C50.7 (2)
C17—O2—C14—C13−177.5 (2)C6—C1—C2—C3−0.3 (2)
C14—O2—C17—C162.3 (4)C1—C2—C3—C40.0 (2)
C13—N1—C1—C6−178.92 (12)C2—C3—C4—C5−0.1 (3)
C7—N1—C13—C14−95.10 (18)C3—C4—C5—C60.4 (2)
C13—N1—C1—C21.4 (2)C4—C5—C6—N2−179.78 (14)
C13—N1—C7—N2178.99 (12)C4—C5—C6—C1−0.8 (2)
C1—N1—C13—C1483.09 (18)N2—C8—C9—C10110.2 (3)
C7—N1—C1—C6−0.47 (14)N2—C8—C9—O1−67.9 (2)
C1—N1—C7—N20.53 (15)C8—C9—C10—C11−179.3 (2)
C7—N1—C1—C2179.86 (15)O1—C9—C10—C11−1.1 (3)
C7—N2—C8—C994.03 (18)C9—C10—C11—C12−0.2 (4)
C7—N2—C6—C10.06 (15)C10—C11—C12—O11.4 (4)
C7—N2—C6—C5179.19 (14)N1—C13—C14—O280.2 (2)
C6—N2—C7—N1−0.37 (15)N1—C13—C14—C15−93.5 (3)
C8—N2—C6—C1177.49 (12)O2—C14—C15—C161.7 (3)
C6—N2—C8—C9−82.98 (18)C13—C14—C15—C16176.0 (2)
C8—N2—C7—N1−177.83 (12)C14—C15—C16—C17−0.3 (4)
C8—N2—C6—C5−3.4 (2)C15—C16—C17—O2−1.2 (4)
C2—C1—C6—N2179.96 (13)
D—H···AD—HH···AD···AD—H···A
O3—HW1···Cl1ii0.93 (3)2.27 (3)3.1563 (17)159 (3)
O3—HW2···Cl10.98 (3)2.22 (3)3.1848 (17)168 (3)
C7—H7···O30.932.223.133 (2)168
C8—H8A···Cl1iii0.972.753.7098 (18)169
C8—H8B···Cl10.972.673.6371 (18)173
C13—H13A···Cl1ii0.972.673.6332 (18)171
C13—H13B···Cl1vii0.972.663.6290 (19)177
C11—H11···Cg2ix0.932.853.641 (4)144
C12—H12···Cg4ix0.932.963.718 (2)139
Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯AD—HH⋯AD⋯AD—H⋯A
O3—HW1⋯Cl1i0.93 (3)2.27 (3)3.1563 (17)159 (3)
O3—HW2⋯Cl10.98 (3)2.22 (3)3.1848 (17)168 (3)
C7—H7⋯O30.932.223.133 (2)168
C8—H8A⋯Cl1ii0.972.753.7098 (18)169
C8—H8B⋯Cl10.972.673.6371 (18)173
C13—H13A⋯Cl1i0.972.673.6332 (18)171
C13—H13B⋯Cl1iii0.972.663.6290 (19)177
C11—H11⋯Cg2iv0.932.853.641 (4)144
C12—H12⋯Cg4iv0.932.963.718 (2)139

Symmetry codes: (i) ; (ii) ; (iii) ; (iv) . Cg2 and Cg4 are the centroids of the O2/C14–C17 furan and C1–C6 benzene rings, respectively.

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Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2009-01-20
  7 in total
  1 in total

1.  2-(Furan-2-yl)-1,3-bis(furan-2-ylmeth-yl)-1H-benzimidazol-3-ium chloride monohydrate.

Authors:  David K Geiger; H Cristina Geiger; Jared M Deck
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-26
  1 in total

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