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Literature DB >> 2158369

Sumatriptan (GR43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein.

Abstract

Sumatriptan (GR43175) contracts rings of dog isolated saphenous vein by an action at 5-HT1-like receptors. We have now examined the effects of sumatriptan on prostaglandin E2(PGE2)-stimulated adenosine 3':5'-cyclic monophosphate (cyclic AMP) accumulation in this tissue. Sumatriptan and 5-hydroxytryptamine (5-HT) produced a concentration-dependent inhibition of PGE2-stimulated cyclic AMP accumulation (EC50 values of 250 nM and 80 nM respectively), responses that were mimicked by 5-carboxamidotryptamine but not by U-46619 or methoxamine. The response to sumatriptan (1 microM) was antagonised by methiothepin (1 microM), but not by metergoline (0.1 microM), spiperone (1 microM) or ondansetron (GR38032, 1 microM). These results suggest that 5-HT1-like receptors which mediate contraction of the dog isolated saphenous vein are negatively coupled to adenylate cyclase in this preparation.

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Year: 1990 PMID： 2158369 PMCID： PMC1917383 DOI： 10.1111/j.1476-5381.1990.tb14682.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

7 in total

Review 1. Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain.

Authors: D Hoyer; D N Middlemiss
Journal: Trends Pharmacol Sci Date: 1989-04 Impact factor: 14.819

2. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites.

Authors: S J Peroutka; B G McCarthy
Journal: Eur J Pharmacol Date: 1989-04-12 Impact factor: 4.432

3. Further characterization of the 5-HT receptor mediating vascular relaxation and elevation of cyclic AMP in porcine isolated vena cava.

Authors: M J Sumner; W Feniuk; P P Humphrey
Journal: Br J Pharmacol Date: 1989-05 Impact factor: 8.739

4. The 5-hydroxytryptamine 5-HT1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra.

Authors: P Schoeffter; C Waeber; J M Palacios; D Hoyer
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1988-06 Impact factor: 3.000

5. GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.

Authors: P P Humphrey; W Feniuk; M J Perren; H E Connor; A W Oxford; L H Coates; D Butina
Journal: Br J Pharmacol Date: 1988-08 Impact factor: 8.739

6. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus.

Authors: P Schoeffter; D Hoyer
Journal: Br J Pharmacol Date: 1988-11 Impact factor: 8.739

7. 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra.

Authors: R Bouhelal; L Smounya; J Bockaert
Journal: Eur J Pharmacol Date: 1988-07-07 Impact factor: 4.432

7 in total

1. 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats.

Authors: M R MacLean; G Sweeney; M Baird; K M McCulloch; M Houslay; I Morecroft
Journal: Br J Pharmacol Date: 1996-11 Impact factor: 8.739

2. The effect of forskolin on 5-HT1-like and angiotensin II-induced vasoconstriction and cyclic AMP content of the rabbit isolated femoral artery.

Authors: V A Randall; S J MacLennan; G R Martin; V G Wilson
Journal: Br J Pharmacol Date: 1996-06 Impact factor: 8.739

3. Phospholipase A2 and protein kinase C contribute to myofilament sensitization to 5-HT in the rabbit mesenteric artery.

Authors: S J Parsons; M J Sumner; C J Garland
Journal: J Physiol Date: 1996-03-01 Impact factor: 5.182

7. Effects of 6-hydroxydopamine on pre- and post-junctional 5-HT1-like receptor-mediated responses in dog saphenous vein.

Authors: A D Medhurst; G E Novotny; S G Parker; N M Deighton; A J Kaumann
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1993-03 Impact factor: 3.000

7 in total

Sumatriptan (GR43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein.

Review 1. Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain.

2. Sumatriptan (GR 43175) interacts selectively with 5-HT1B and 5-HT1D binding sites.

3. Further characterization of the 5-HT receptor mediating vascular relaxation and elevation of cyclic AMP in porcine isolated vena cava.

4. The 5-hydroxytryptamine 5-HT1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra.

5. GR43175, a selective agonist for the 5-HT1-like receptor in dog isolated saphenous vein.

6. Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus.

7. 5-HT1B receptors are negatively coupled with adenylate cyclase in rat substantia nigra.

1. 5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats.

2. The effect of forskolin on 5-HT1-like and angiotensin II-induced vasoconstriction and cyclic AMP content of the rabbit isolated femoral artery.

3. Phospholipase A2 and protein kinase C contribute to myofilament sensitization to 5-HT in the rabbit mesenteric artery.

4. 5-hydroxytryptamine stimulation of phospholipase D activity in the rabbit isolated mesenteric artery.

5. Role of 5-HT1-like receptors in the reduction of porcine cranial arteriovenous anastomotic shunting by sumatriptan.

6. Studies on the mechanism of 5-HT1 receptor-induced smooth muscle contraction in dog saphenous vein.

7. Effects of 6-hydroxydopamine on pre- and post-junctional 5-HT1-like receptor-mediated responses in dog saphenous vein.