1-Ethyl-1H,6H-pyrrolo[2,3-c]azepine-4,8(5H,7H)-dione.

The title compound, C(10)H(12)N(2)O(2), was synthesized by cyclization of 3-(1-ethyl-pyrrole-2-carboxamido)propanoic acid in the presence of polyphospho-ric acid and diphospho-rus pentoxide. In the crystal structure, adjacent mol-ecules are linked by N-H⋯O hydrogen bonds, forming chains extending along the b axis.

Related literature

For pyrroles sourced from marine organisms, see: Liu et al. (2005 ▶). For the bioactivity of pyrrole derivatives, see: Banwell et al. (2006 ▶); Sosa et al. (2002 ▶). For related structures, see: Zeng (2006 ▶); Zeng et al. (2005 ▶).

Experimental

Crystal data

C10H12N2O2

M = 192.22

Monoclinic,

a = 11.703 (2) Å

b = 7.7863 (13) Å

c = 11.0004 (19) Å

β = 113.878 (3)°

V = 916.6 (3) Å3

Z = 4

Mo Kα radiation

μ = 0.10 mm−1

T = 173 K

0.46 × 0.45 × 0.30 mm

Data collection

Bruker SMART 1K CCD area-detector diffractometer

Absorption correction: multi-scan (SADABS; Sheldrick, 1996 ▶) T min = 0.956, T max = 0.971

4523 measured reflections

1984 independent reflections

1661 reflections with I > 2σ(I)

R int = 0.021

Refinement

R[F 2 > 2σ(F 2)] = 0.037

wR(F 2) = 0.104

S = 1.07

1984 reflections

128 parameters

H-atom parameters constrained

Δρmax = 0.28 e Å−3

Δρmin = −0.21 e Å−3

Data collection: SMART (Bruker,1999 ▶); cell refinement: SAINT-Plus (Bruker, 1999 ▶); data reduction: SAINT-Plus; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXTL.

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536809027378/jh2089sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536809027378/jh2089Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C10H12N2O2	Dx = 1.393 Mg m−3
Mr = 192.22	Melting point: 428 K
Monoclinic, P21/c	Mo Kα radiation, λ = 0.71073 Å
a = 11.703 (2) Å	Cell parameters from 2801 reflections
b = 7.7863 (13) Å	θ = 3.2–27.0°
c = 11.0004 (19) Å	µ = 0.10 mm−1
β = 113.878 (3)°	T = 173 K
V = 916.6 (3) Å3	Block, colourless
Z = 4	0.46 × 0.45 × 0.30 mm
F(000) = 408

Bruker SMART 1K CCD area-detector diffractometer	1984 independent reflections
Radiation source: fine-focus sealed tube	1661 reflections with I > 2σ(I)
graphite	Rint = 0.021
φ and ω scans	θmax = 27.0°, θmin = 1.9°
Absorption correction: multi-scan (SADABS; Sheldrick, 1996)	h = −14→10
Tmin = 0.956, Tmax = 0.971	k = −9→6
4523 measured reflections	l = −11→14

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.037	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.104	H-atom parameters constrained
S = 1.07	w = 1/[σ2(Fo2) + (0.0534P)2 + 0.2795P] where P = (Fo2 + 2Fc2)/3
1984 reflections	(Δ/σ)max = 0.001
128 parameters	Δρmax = 0.28 e Å−3
0 restraints	Δρmin = −0.21 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
O2	0.07477 (9)	0.05619 (12)	0.30383 (10)	0.0317 (3)
O1	0.47580 (8)	0.04303 (12)	0.16872 (9)	0.0277 (2)
N2	0.35948 (10)	0.26744 (13)	0.18305 (11)	0.0239 (3)
H2A	0.4269	0.3322	0.2129	0.029*
N1	0.24341 (10)	−0.13996 (13)	0.02340 (10)	0.0222 (3)
C5	0.37313 (11)	0.10354 (16)	0.15418 (12)	0.0210 (3)
C1	0.14174 (12)	−0.23379 (16)	0.01642 (13)	0.0255 (3)
H1	0.1100	−0.3328	−0.0372	0.031*
C4	0.25889 (11)	−0.00413 (15)	0.10751 (12)	0.0201 (3)
C7	0.19395 (13)	0.28160 (17)	0.26984 (14)	0.0276 (3)
H7A	0.2634	0.2860	0.3591	0.033*
H7B	0.1283	0.3613	0.2705	0.033*
C3	0.16546 (11)	−0.01426 (15)	0.15559 (12)	0.0212 (3)
C8	0.14076 (11)	0.10147 (16)	0.24709 (12)	0.0231 (3)
C2	0.09348 (12)	−0.16271 (16)	0.09844 (13)	0.0247 (3)
H2	0.0246	−0.2046	0.1144	0.030*
C9	0.31226 (13)	−0.17678 (16)	−0.05965 (13)	0.0257 (3)
H9A	0.3682	−0.0790	−0.0542	0.031*
H9B	0.2521	−0.1882	−0.1534	0.031*
C10	0.38929 (13)	−0.33927 (18)	−0.01768 (14)	0.0312 (3)
H10A	0.4517	−0.3265	0.0737	0.047*
H10B	0.4315	−0.3600	−0.0771	0.047*
H10C	0.3345	−0.4365	−0.0225	0.047*
C6	0.24223 (12)	0.34703 (16)	0.16897 (13)	0.0243 (3)
H6A	0.1785	0.3245	0.0783	0.029*
H6B	0.2543	0.4729	0.1793	0.029*

	U11	U22	U33	U12	U13	U23
O2	0.0380 (6)	0.0290 (5)	0.0366 (5)	0.0024 (4)	0.0237 (5)	0.0032 (4)
O1	0.0232 (5)	0.0257 (5)	0.0347 (5)	0.0027 (4)	0.0123 (4)	0.0015 (4)
N2	0.0223 (5)	0.0189 (5)	0.0302 (6)	−0.0029 (4)	0.0102 (4)	−0.0020 (4)
N1	0.0253 (5)	0.0184 (5)	0.0222 (5)	0.0012 (4)	0.0090 (4)	−0.0004 (4)
C5	0.0232 (6)	0.0204 (6)	0.0199 (6)	0.0015 (5)	0.0091 (5)	0.0027 (5)
C1	0.0263 (7)	0.0192 (6)	0.0271 (6)	−0.0014 (5)	0.0068 (5)	−0.0011 (5)
C4	0.0237 (6)	0.0163 (5)	0.0191 (6)	0.0025 (5)	0.0075 (5)	0.0017 (4)
C7	0.0320 (7)	0.0230 (6)	0.0315 (7)	−0.0004 (5)	0.0168 (6)	−0.0045 (5)
C3	0.0215 (6)	0.0188 (6)	0.0217 (6)	0.0026 (5)	0.0072 (5)	0.0033 (5)
C8	0.0231 (6)	0.0231 (6)	0.0224 (6)	0.0043 (5)	0.0086 (5)	0.0034 (5)
C2	0.0228 (6)	0.0210 (6)	0.0287 (6)	−0.0011 (5)	0.0089 (5)	0.0031 (5)
C9	0.0320 (7)	0.0237 (6)	0.0235 (6)	0.0030 (5)	0.0135 (5)	−0.0007 (5)
C10	0.0341 (8)	0.0283 (7)	0.0308 (7)	0.0077 (6)	0.0128 (6)	−0.0025 (6)
C6	0.0276 (7)	0.0170 (6)	0.0283 (6)	0.0023 (5)	0.0114 (5)	−0.0002 (5)

O2—C8	1.2250 (15)	C7—H7A	0.9900
O1—C5	1.2393 (15)	C7—H7B	0.9900
N2—C5	1.3402 (16)	C3—C2	1.4185 (17)
N2—C6	1.4556 (16)	C3—C8	1.4643 (18)
N2—H2A	0.8800	C2—H2	0.9500
N1—C4	1.3681 (16)	C9—C10	1.5131 (18)
N1—C1	1.3716 (16)	C9—H9A	0.9900
N1—C9	1.4704 (16)	C9—H9B	0.9900
C5—C4	1.4826 (17)	C10—H10A	0.9800
C1—C2	1.3609 (19)	C10—H10B	0.9800
C1—H1	0.9500	C10—H10C	0.9800
C4—C3	1.3964 (17)	C6—H6A	0.9900
C7—C8	1.5137 (18)	C6—H6B	0.9900
C7—C6	1.5223 (18)
C5—N2—C6	125.30 (11)	O2—C8—C3	120.92 (12)
C5—N2—H2A	117.4	O2—C8—C7	118.97 (11)
C6—N2—H2A	117.4	C3—C8—C7	120.09 (11)
C4—N1—C1	108.91 (10)	C1—C2—C3	107.09 (11)
C4—N1—C9	127.96 (11)	C1—C2—H2	126.5
C1—N1—C9	122.85 (11)	C3—C2—H2	126.5
O1—C5—N2	122.26 (12)	N1—C9—C10	112.47 (11)
O1—C5—C4	121.40 (11)	N1—C9—H9A	109.1
N2—C5—C4	116.31 (11)	C10—C9—H9A	109.1
C2—C1—N1	109.25 (11)	N1—C9—H9B	109.1
C2—C1—H1	125.4	C10—C9—H9B	109.1
N1—C1—H1	125.4	H9A—C9—H9B	107.8
N1—C4—C3	107.63 (11)	C9—C10—H10A	109.5
N1—C4—C5	121.69 (11)	C9—C10—H10B	109.5
C3—C4—C5	129.45 (11)	H10A—C10—H10B	109.5
C8—C7—C6	116.02 (11)	C9—C10—H10C	109.5
C8—C7—H7A	108.3	H10A—C10—H10C	109.5
C6—C7—H7A	108.3	H10B—C10—H10C	109.5
C8—C7—H7B	108.3	N2—C6—C7	113.08 (11)
C6—C7—H7B	108.3	N2—C6—H6A	109.0
H7A—C7—H7B	107.4	C7—C6—H6A	109.0
C4—C3—C2	107.08 (11)	N2—C6—H6B	109.0
C4—C3—C8	128.93 (11)	C7—C6—H6B	109.0
C2—C3—C8	123.99 (12)	H6A—C6—H6B	107.8
C6—N2—C5—O1	−179.77 (11)	C5—C4—C3—C8	13.5 (2)
C6—N2—C5—C4	−1.61 (17)	C4—C3—C8—O2	−163.02 (12)
C4—N1—C1—C2	−1.80 (14)	C2—C3—C8—O2	17.16 (19)
C9—N1—C1—C2	−176.11 (11)	C4—C3—C8—C7	18.71 (19)
C1—N1—C4—C3	0.68 (13)	C2—C3—C8—C7	−161.10 (12)
C9—N1—C4—C3	174.62 (11)	C6—C7—C8—O2	−162.98 (12)
C1—N1—C4—C5	169.12 (11)	C6—C7—C8—C3	15.32 (17)
C9—N1—C4—C5	−16.93 (18)	N1—C1—C2—C3	2.15 (14)
O1—C5—C4—N1	−30.73 (17)	C4—C3—C2—C1	−1.71 (14)
N2—C5—C4—N1	151.09 (11)	C8—C3—C2—C1	178.14 (11)
O1—C5—C4—C3	134.95 (14)	C4—N1—C9—C10	114.79 (14)
N2—C5—C4—C3	−43.23 (18)	C1—N1—C9—C10	−72.04 (15)
N1—C4—C3—C2	0.63 (13)	C5—N2—C6—C7	69.94 (16)
C5—C4—C3—C2	−166.62 (12)	C8—C7—C6—N2	−72.98 (15)
N1—C4—C3—C8	−179.21 (11)

D—H···A	D—H	H···A	D···A	D—H···A
N2—H2A···O1i	0.88	2.12	2.9043 (14)	148

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
N2—H2A⋯O1i	0.88	2.12	2.9043 (14)	148

Symmetry code: (i) .