Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.

Literature DB >> 2158278

Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.

J F Manischewitz¹, G V Quinnan, H C Lane, A E Wittek.

Abstract

Ganciclovir and foscarnet possess substantial activity against cytomegalovirus. Both exhibit dose-limiting toxicity, which reduces their clinical usefulness. We demonstrated synergistic inhibition of cytomegalovirus replication in vitro by ganciclovir and foscarnet. Reduced-dose combination therapy may provide a means to treat patients with cytomegalovirus infection while reducing drug toxicity.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1990 PMID： 2158278 PMCID： PMC171593 DOI： 10.1128/AAC.34.2.373

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

17 in total

1. Effect of adenine arabinoside on cytomegalovirus infections.

Authors: L T Ch'ien; N J Cannon; R J Whitley; A G Diethelm; W E Dismukes; C W Scott; R A Buchanan; C A Alford
Journal: J Infect Dis Date: 1974-07 Impact factor: 5.226

2. Pharmacokinetics, safety and preliminary clinical experiences using foscarnet in the treatment of cytomegalovirus infections in bone marrow and renal transplant recipients.

Authors: O Ringdén; B Lönnqvist; T Paulin; J Ahlmén; G Klintmalm; B Wahren; J O Lernestedt
Journal: J Antimicrob Chemother Date: 1986-03 Impact factor: 5.790

3. Risk factors for cytomegalovirus infection after human marrow transplantation.

Authors: J D Meyers; N Flournoy; E D Thomas
Journal: J Infect Dis Date: 1986-03 Impact factor: 5.226

4. Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men.

Authors: H Masur; H C Lane; A Palestine; P D Smith; J Manischewitz; G Stevens; L Fujikawa; A M Macher; R Nussenblatt; B Baird
Journal: Ann Intern Med Date: 1986-01 Impact factor: 25.391

Review 5. Antiviral activity and mechanism of action of ganciclovir.

Authors: T Matthews; R Boehme
Journal: Rev Infect Dis Date: 1988 Jul-Aug

6. Treatment of cytomegalovirus pneumonia with high-dose acyclovir.

Authors: J C Wade; M Hintz; R McGuffin; S C Springmeyer; J D Connor; J D Meyers
Journal: Am J Med Date: 1982-07-20 Impact factor: 4.965

7. Treatment of cytomegalovirus retinitis with trisodium phosphonoformate hexahydrate (Foscarnet).

Authors: S L Walmsley; E Chew; S E Read; H Vellend; I Salit; A Rachlis; M M Fanning
Journal: J Infect Dis Date: 1988-03 Impact factor: 5.226

8. Intravenous foscarnet for the treatment of severe cytomegalovirus infection in allograft recipients.

Authors: G Klintmalm; B Lönnqvist; B Oberg; G Gahrton; J O Lernestedt; G Lundgren; O Ringdén; K H Robert; B Wahren; C G Groth
Journal: Scand J Infect Dis Date: 1985

9. Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro.

Authors: E C Mar; Y C Cheng; E S Huang
Journal: Antimicrob Agents Chemother Date: 1983-10 Impact factor: 5.191

10. Activity of 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine in the treatment of cytomegalovirus pneumonia.

Authors: D H Shepp; P S Dandliker; P de Miranda; T C Burnette; D M Cederberg; L E Kirk; J D Meyers
Journal: Ann Intern Med Date: 1985-09 Impact factor: 25.391

18 in total

1. The intracellular activation of lamivudine (3TC) and determination of 2'-deoxycytidine-5'-triphosphate (dCTP) pools in the presence and absence of various drugs in HepG2 cells.

Authors: S Kewn; P G Hoggard; S D Sales; M A Johnson; D J Back
Journal: Br J Clin Pharmacol Date: 2000-12 Impact factor: 4.335

2. Activity of different antiviral drug combinations against human cytomegalovirus replication in vitro.

Authors: R Snoeck; G Andrei; D Schols; J Balzarini; E De Clercq
Journal: Eur J Clin Microbiol Infect Dis Date: 1992-12 Impact factor: 3.267

Review 3. Resistance of herpesviruses to antiviral drugs.

Authors: P A Chatis; C S Crumpacker
Journal: Antimicrob Agents Chemother Date: 1992-08 Impact factor: 5.191

Review 4. [Infections of the central nervous system in the immuno-compromised].

Authors: E Schmutzhard; B Pfausler
Journal: Nervenarzt Date: 2008-09 Impact factor: 1.214

5. Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient.

Authors: Jacob T Kilgore; Bradford Becken; Matthew G Varga; Suhag Parikh; Vinod Prasad; Debra Lugo; Yeh-Chung Chang
Journal: J Pediatric Infect Dis Soc Date: 2020-09-17 Impact factor: 3.164

Review 6. New strategies for prevention and therapy of cytomegalovirus infection and disease in solid-organ transplant recipients.

Authors: I G Sia; R Patel
Journal: Clin Microbiol Rev Date: 2000-01 Impact factor: 26.132

Review 10. Ocular complications of the acquired immunodeficiency syndrome. Focus on the treatment of cytomegalovirus retinitis with ganciclovir and foscarnet.

Authors: W J Keijer; D M Burger; G H Neuteboom; J L Vrooland; P L Meenhorst; C H Koks; J H Beijnen
Journal: Pharm World Sci Date: 1993-04-23