Literature DB >> 21582018

2-({3-[(2R,4S,5R)-4-Hydr-oxy-5-hydroxy-methyl-2,3,4,5-tetra-hydro-furan-2-yl]-5-methyl-2,6-dioxo-1,2,3,6-tetra-hydro-pyrimidin-1-yl}meth-yl)isoindoline-1,3-dione.

Mark Daniel Bartholomä, Wayne Ouellette, Jon Zubieta.   

Abstract

The title compound, C(19)H(19)N(3)O(7), is a thymidine derivative and serves as an inter-mediate in the synthesis of a (99m)Tc radiolabeled nucleoside analog. Inter-molecular O-H⋯O hydrogen bonding is observed between the hydr-oxy functionalities of the ribose unit themselves as well as between a hydr-oxy group and an O atom of the phthalimide group of an adjacent mol-ecule. The mol-ecules are stacked on top of each other in the direction of the a axis. The crystal packing is further stabilized by weak intra- and inter-molecular C-H⋯O hydrogen bonds. The absolute configuration of the compound is known from the synthesis.

Entities:  

Year:  2009        PMID: 21582018      PMCID: PMC2968204          DOI: 10.1107/S1600536809003365

Source DB:  PubMed          Journal:  Acta Crystallogr Sect E Struct Rep Online        ISSN: 1600-5368


  7 in total

Review 1.  Structure and function of cellular deoxyribonucleoside kinases.

Authors:  S Eriksson; B Munch-Petersen; K Johansson; H Eklund
Journal:  Cell Mol Life Sci       Date:  2002-08       Impact factor: 9.261

2.  Structures of thymidine kinase 1 of human and mycoplasmic origin.

Authors:  Martin Welin; Urszula Kosinska; Nils-Egil Mikkelsen; Cecilia Carnrot; Chunying Zhu; Liya Wang; Staffan Eriksson; Birgitte Munch-Petersen; Hans Eklund
Journal:  Proc Natl Acad Sci U S A       Date:  2004-12-20       Impact factor: 11.205

3.  A short history of SHELX.

Authors:  George M Sheldrick
Journal:  Acta Crystallogr A       Date:  2007-12-21       Impact factor: 2.290

4.  Regulation of thymidine kinase synthesis in human cells.

Authors:  L J Bello
Journal:  Exp Cell Res       Date:  1974-12       Impact factor: 3.905

5.  Rhenium tricarbonyl core complexes of thymidine and uridine derivatives.

Authors:  Lihui Wei; John Babich; William C Eckelman; Jon Zubieta
Journal:  Inorg Chem       Date:  2005-04-04       Impact factor: 5.165

Review 6.  Single amino acid chelates (SAAC): a strategy for the design of technetium and rhenium radiopharmaceuticals.

Authors:  Mark Bartholomä; John Valliant; Kevin P Maresca; John Babich; Jon Zubieta
Journal:  Chem Commun (Camb)       Date:  2008-12-01       Impact factor: 6.222

Review 7.  Mammalian deoxyribonucleoside kinases.

Authors:  E S Arnér; S Eriksson
Journal:  Pharmacol Ther       Date:  1995       Impact factor: 12.310

  7 in total

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