Literature DB >> 2158158

Okadaic acid: a new probe for the study of cellular regulation.

P Cohen1, C F Holmes, Y Tsukitani.   

Abstract

The tumour promoter okadaic acid is a potent and specific inhibitor of protein phosphatases 1 and 2A. Here we review recent studies which demonstrate that this toxin is extremely useful for identifying biological processes that are controlled through the reversible phosphorylation of proteins.

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Year:  1990        PMID： 2158158     DOI： 10.1016/0968-0004(90)90192-e

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  283 in total

1.  Inhibition of mouse neuromuscular transmission and contractile function by okadaic acid and cantharidin.

Authors:  S J Hong
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

2.  Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits.

Authors:  Adam M Silverstein; Christina A Barrow; Anthony J Davis; Marc C Mumby
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-19       Impact factor: 11.205

3.  The protein phosphatase inhibitor calyculin A mimics elicitor action in plant cells and induces rapid hyperphosphorylation of specific proteins as revealed by pulse labeling with [33P]phosphate.

Authors:  G Felix; M Regenass; P Spanu; T Boller
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

4.  Differential expression of 1-aminocyclopropane-1-carboxylate synthase genes during orchid flower senescence induced by the protein phosphatase inhibitor okadaic acid.

Authors:  N N Wang; S F Yang; Y Charng
Journal:  Plant Physiol       Date:  2001-05       Impact factor: 8.340

Review 5.  Neurotoxic and synaptic effects of okadaic acid, an inhibitor of protein phosphatases.

Authors:  R Tapia; F Peña; C Arias
Journal:  Neurochem Res       Date:  1999-11       Impact factor: 3.996

6.  Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.

Authors:  S E Merrick; J Q Trojanowski; V M Lee
Journal:  J Neurosci       Date:  1997-08-01       Impact factor: 6.167

7.  Nitrate activation of cytosolic protein kinases diverts photosynthetic carbon from sucrose to amino Acid biosynthesis: basis for a new concept.

Authors:  M L Champigny; C Foyer
Journal:  Plant Physiol       Date:  1992-09       Impact factor: 8.340

8.  Lack of Types 1 and 2A Protein Serine(P)/Threonine(P) Phosphatase Activities in Chloroplasts.

Authors:  G Sun; J Markwell
Journal:  Plant Physiol       Date:  1992-10       Impact factor: 8.340

9.  TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.

Authors:  Jennifer A Fairley; Pamela H Scott; Robert J White
Journal:  EMBO J       Date:  2003-11-03       Impact factor: 11.598

10.  The role of tau phosphorylation in transfected COS-1 cells.

Authors:  M Medina; E Montejo de Garcini; J Avila
Journal:  Mol Cell Biochem       Date:  1995-07-05       Impact factor: 3.396
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