Methyl 3,5-bis-[(4-hydroxy-methyl-2-methoxy-phen-oxy)meth-yl]benzoate.

In the title compound, C(26)H(28)O(8), the central aromatic ring forms dihedral angles of 24.32 (11) and 80.19 (7)° with the two adjoining vanillyl alcohol rings. In the crystal, O-H⋯O hydrogen bonds connect the mol-ecules, forming a hydrogen-bonded sheet-like motif extended in the ab plane.

Related literature

For the synthesis of and background to adjoined vanillyl alcohols, see: Mough et al. (2004 ▶); Mough & Holman (2008 ▶). For background to cryptophanes, see: Brotin & Dutasta (2009 ▶).

Experimental

Crystal data

C26H28O8

M = 468.48

Triclinic,

a = 4.7707 (12) Å

b = 14.844 (4) Å

c = 16.349 (4) Å

α = 99.801 (5)°

β = 95.692 (5)°

γ = 92.821 (5)°

V = 1132.7 (5) Å3

Z = 2

Mo Kα radiation

μ = 0.10 mm−1

T = 173 K

0.50 × 0.25 × 0.05 mm

Data collection

Bruker SMART 1K diffractometer

Absorption correction: multi-scan (SADABS; Bruker, 2001 ▶) T min = 0.951, T max = 0.995

6559 measured reflections

4394 independent reflections

2197 reflections with I > 2σ(I)

R int = 0.037

Refinement

R[F 2 > 2σ(F 2)] = 0.054

wR(F 2) = 0.128

S = 0.85

4394 reflections

312 parameters

H-atom parameters constrained

Δρmax = 0.40 e Å−3

Δρmin = −0.22 e Å−3

Data collection: SMART (Bruker, 2001 ▶); cell refinement: SAINT (Bruker, 2001 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 (Farrugia, 1997 ▶), PLATON (Spek, 2009 ▶) and X-SEED (Barbour, 2001 ▶); software used to prepare material for publication: WinGX (Farrugia, 1999 ▶) and PLATON.

Crystal structure: contains datablocks global, I. DOI: 10.1107/S160053681000677X/ng2730sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S160053681000677X/ng2730Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C26H28O8	Z = 2
Mr = 468.48	F(000) = 496
Triclinic, P1	Dx = 1.374 Mg m−3
Hall symbol: -P 1	Mo Kα radiation, λ = 0.71073 Å
a = 4.7707 (12) Å	Cell parameters from 1285 reflections
b = 14.844 (4) Å	θ = 2.5–24.5°
c = 16.349 (4) Å	µ = 0.10 mm−1
α = 99.801 (5)°	T = 173 K
β = 95.692 (5)°	Needle, pale yellow
γ = 92.821 (5)°	0.50 × 0.25 × 0.05 mm
V = 1132.7 (5) Å3

Bruker SMART K1 diffractometer	4394 independent reflections
Radiation source: fine-focus sealed tube	2197 reflections with I > 2σ(I)
graphite	Rint = 0.037
ω scan	θmax = 26.0°, θmin = 1.7°
Absorption correction: multi-scan (SADABS; Bruker, 2001)	h = −5→5
Tmin = 0.951, Tmax = 0.995	k = −16→18
6559 measured reflections	l = −18→20

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.054	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.128	H-atom parameters constrained
S = 0.85	w = 1/[σ2(Fo2) + (0.0568P)2] where P = (Fo2 + 2Fc2)/3
4394 reflections	(Δ/σ)max < 0.001
312 parameters	Δρmax = 0.40 e Å−3
0 restraints	Δρmin = −0.22 e Å−3

Geometry. All s.u.'s (except the s.u. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell s.u.'s are taken into account individually in the estimation of s.u.'s in distances, angles and torsion angles; correlations between s.u.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell s.u.'s is used for estimating s.u.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > 2σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
O1	0.8577 (4)	0.44795 (11)	0.18004 (10)	0.0323 (5)
C1	0.3350 (6)	0.66420 (18)	0.21353 (17)	0.0325 (7)
O2	0.6676 (4)	0.49101 (12)	0.32243 (10)	0.0400 (5)
C2	0.4117 (6)	0.61493 (18)	0.27658 (17)	0.0329 (7)
H2	0.3434	0.6310	0.3294	0.039*
O3	0.2404 (4)	0.80315 (13)	0.30289 (13)	0.0490 (6)
H3	0.1081	0.8346	0.3191	0.059*
C3	0.5843 (6)	0.54346 (18)	0.26403 (16)	0.0319 (7)
O4	1.3168 (6)	0.15167 (15)	−0.10157 (14)	0.0725 (8)
C4	0.6859 (5)	0.51921 (17)	0.18579 (16)	0.0285 (6)
O5	1.6491 (5)	0.09734 (14)	−0.02106 (13)	0.0614 (7)
C5	0.6078 (5)	0.56715 (18)	0.12281 (16)	0.0299 (7)
H5	0.6727	0.5508	0.0695	0.036*
O6	1.4405 (4)	0.26847 (12)	0.34342 (10)	0.0352 (5)
C6	0.4340 (6)	0.63941 (17)	0.13746 (16)	0.0319 (7)
H6	0.3828	0.6723	0.0939	0.038*
O7	1.1515 (4)	0.28885 (12)	0.46990 (11)	0.0436 (5)
C7	0.1416 (6)	0.74113 (18)	0.22818 (17)	0.0409 (8)
H7A	0.1326	0.7742	0.1803	0.049*
H7B	−0.0512	0.7157	0.2324	0.049*
O8	0.7672 (4)	−0.11335 (12)	0.34750 (13)	0.0489 (6)
H8	0.6119	−0.1407	0.3263	0.059*
C8	0.5065 (7)	0.4943 (2)	0.39253 (16)	0.0499 (9)
H8A	0.5503	0.5532	0.4303	0.075*
H8B	0.5547	0.4443	0.4224	0.075*
H8C	0.3045	0.4877	0.3727	0.075*
C9	0.9429 (6)	0.41381 (17)	0.10055 (15)	0.0304 (7)
H9A	1.0410	0.4637	0.0789	0.036*
H9B	0.7755	0.3897	0.0607	0.036*
C10	1.1380 (6)	0.33864 (17)	0.10909 (16)	0.0286 (6)
C11	1.2673 (5)	0.32889 (17)	0.18610 (16)	0.0283 (6)
H11	1.2218	0.3673	0.2350	0.034*
C12	1.4638 (5)	0.26345 (17)	0.19325 (16)	0.0287 (6)
C13	1.5267 (6)	0.20702 (18)	0.12191 (17)	0.0351 (7)
H13	1.6623	0.1628	0.1261	0.042*
C14	1.3922 (6)	0.21470 (18)	0.04403 (17)	0.0373 (7)
C15	1.1980 (6)	0.28043 (17)	0.03803 (17)	0.0327 (7)
H15	1.1055	0.2856	−0.0150	0.039*
C16	1.4431 (8)	0.1529 (2)	−0.0346 (2)	0.0472 (9)
C17	1.7031 (9)	0.0358 (2)	−0.0969 (2)	0.0867 (14)
H17A	1.5272	0.0010	−0.1226	0.130*
H17B	1.8436	−0.0066	−0.0827	0.130*
H17C	1.7746	0.0719	−0.1363	0.130*
C18	1.6184 (6)	0.25862 (18)	0.27714 (16)	0.0357 (7)
H18A	1.7048	0.1990	0.2739	0.043*
H18B	1.7730	0.3075	0.2904	0.043*
C19	1.2662 (5)	0.19350 (18)	0.34944 (16)	0.0300 (7)
C20	1.2295 (6)	0.11288 (18)	0.29360 (16)	0.0338 (7)
H20	1.3278	0.1060	0.2454	0.041*
C21	1.0492 (6)	0.04030 (18)	0.30645 (16)	0.0353 (7)
H21	1.0240	−0.0149	0.2666	0.042*
C22	0.9088 (6)	0.04871 (18)	0.37649 (16)	0.0310 (7)
C23	0.9420 (6)	0.13196 (18)	0.43279 (16)	0.0346 (7)
H23	0.8427	0.1388	0.4808	0.042*
C24	1.1169 (6)	0.20460 (18)	0.41988 (16)	0.0318 (7)
C25	0.7190 (6)	−0.02789 (18)	0.39519 (17)	0.0374 (7)
H25A	0.7527	−0.0311	0.4553	0.045*
H25B	0.5194	−0.0145	0.3830	0.045*
C26	0.9726 (7)	0.3043 (2)	0.53515 (18)	0.0574 (10)
H26A	0.7749	0.2921	0.5113	0.086*
H26B	1.0032	0.3681	0.5639	0.086*
H26C	1.0167	0.2634	0.5750	0.086*

	U11	U22	U33	U12	U13	U23
O1	0.0385 (12)	0.0315 (11)	0.0290 (10)	0.0110 (9)	0.0096 (9)	0.0052 (8)
C1	0.0261 (16)	0.0276 (16)	0.0426 (17)	−0.0002 (12)	0.0008 (14)	0.0049 (13)
O2	0.0550 (14)	0.0404 (12)	0.0295 (10)	0.0163 (10)	0.0141 (10)	0.0110 (9)
C2	0.0346 (17)	0.0310 (17)	0.0326 (16)	0.0031 (13)	0.0112 (14)	−0.0002 (13)
O3	0.0348 (13)	0.0368 (13)	0.0694 (14)	0.0063 (10)	0.0067 (11)	−0.0090 (11)
C3	0.0349 (17)	0.0292 (17)	0.0333 (16)	0.0034 (13)	0.0063 (14)	0.0086 (13)
O4	0.120 (2)	0.0577 (16)	0.0399 (14)	0.0244 (15)	0.0195 (15)	−0.0019 (12)
C4	0.0276 (16)	0.0265 (16)	0.0308 (15)	−0.0001 (12)	0.0068 (13)	0.0020 (12)
O5	0.0712 (17)	0.0463 (14)	0.0649 (15)	0.0127 (12)	0.0290 (14)	−0.0101 (12)
C5	0.0316 (17)	0.0332 (16)	0.0256 (14)	0.0006 (13)	0.0071 (13)	0.0050 (12)
O6	0.0340 (12)	0.0325 (12)	0.0412 (11)	0.0042 (9)	0.0086 (10)	0.0091 (9)
C6	0.0339 (17)	0.0299 (16)	0.0324 (16)	0.0017 (13)	0.0022 (14)	0.0080 (13)
O7	0.0512 (14)	0.0371 (12)	0.0403 (11)	−0.0025 (10)	0.0139 (11)	−0.0028 (10)
C7	0.0418 (19)	0.0323 (17)	0.0476 (18)	0.0070 (14)	0.0039 (16)	0.0034 (14)
O8	0.0357 (13)	0.0330 (12)	0.0749 (15)	0.0017 (9)	0.0107 (12)	−0.0023 (11)
C8	0.079 (3)	0.044 (2)	0.0330 (16)	0.0115 (17)	0.0238 (17)	0.0128 (14)
C9	0.0321 (16)	0.0332 (16)	0.0266 (14)	0.0019 (13)	0.0064 (13)	0.0058 (12)
C10	0.0297 (16)	0.0279 (16)	0.0292 (15)	−0.0016 (12)	0.0101 (13)	0.0048 (12)
C11	0.0279 (16)	0.0285 (16)	0.0285 (15)	−0.0008 (12)	0.0090 (13)	0.0020 (12)
C12	0.0264 (16)	0.0254 (15)	0.0359 (16)	0.0016 (12)	0.0084 (13)	0.0072 (13)
C13	0.0308 (17)	0.0282 (16)	0.0499 (18)	0.0056 (13)	0.0171 (15)	0.0083 (14)
C14	0.047 (2)	0.0292 (17)	0.0381 (17)	−0.0022 (14)	0.0216 (16)	0.0051 (14)
C15	0.0369 (18)	0.0280 (16)	0.0338 (16)	−0.0013 (13)	0.0102 (14)	0.0045 (13)
C16	0.061 (2)	0.0284 (18)	0.055 (2)	0.0008 (16)	0.027 (2)	0.0027 (17)
C17	0.115 (4)	0.055 (2)	0.088 (3)	0.012 (2)	0.059 (3)	−0.022 (2)
C18	0.0301 (17)	0.0334 (17)	0.0472 (18)	0.0090 (13)	0.0123 (15)	0.0106 (14)
C19	0.0228 (16)	0.0320 (17)	0.0370 (16)	0.0043 (13)	0.0029 (13)	0.0111 (13)
C20	0.0371 (18)	0.0314 (17)	0.0349 (15)	0.0086 (14)	0.0095 (14)	0.0065 (13)
C21	0.0398 (18)	0.0298 (17)	0.0351 (16)	0.0089 (14)	0.0039 (14)	0.0010 (13)
C22	0.0271 (16)	0.0317 (17)	0.0341 (15)	0.0049 (13)	0.0011 (13)	0.0062 (13)
C23	0.0349 (17)	0.0405 (18)	0.0302 (15)	0.0078 (14)	0.0069 (13)	0.0080 (13)
C24	0.0312 (17)	0.0320 (17)	0.0310 (15)	0.0037 (13)	0.0016 (13)	0.0025 (13)
C25	0.0323 (17)	0.0338 (18)	0.0459 (17)	0.0051 (13)	0.0080 (15)	0.0032 (14)
C26	0.071 (3)	0.050 (2)	0.0486 (19)	−0.0013 (18)	0.0276 (19)	−0.0092 (16)

O1—C4	1.366 (3)	C9—H9B	0.9900
O1—C9	1.418 (3)	C10—C11	1.380 (3)
C1—C6	1.372 (3)	C10—C15	1.388 (3)
C1—C2	1.393 (4)	C11—C12	1.394 (4)
C1—C7	1.506 (4)	C11—H11	0.9500
O2—C3	1.372 (3)	C12—C13	1.383 (3)
O2—C8	1.437 (3)	C12—C18	1.506 (4)
C2—C3	1.375 (4)	C13—C14	1.393 (4)
C2—H2	0.9500	C13—H13	0.9500
O3—C7	1.422 (3)	C14—C15	1.387 (4)
O3—H3	0.8400	C14—C16	1.495 (4)
C3—C4	1.409 (3)	C15—H15	0.9500
O4—C16	1.193 (4)	C17—H17A	0.9800
C4—C5	1.380 (3)	C17—H17B	0.9800
O5—C16	1.339 (4)	C17—H17C	0.9800
O5—C17	1.462 (3)	C18—H18A	0.9900
C5—C6	1.391 (4)	C18—H18B	0.9900
C5—H5	0.9500	C19—C20	1.368 (3)
O6—C19	1.379 (3)	C19—C24	1.404 (3)
O6—C18	1.434 (3)	C20—C21	1.402 (3)
C6—H6	0.9500	C20—H20	0.9500
O7—C24	1.366 (3)	C21—C22	1.374 (3)
O7—C26	1.427 (3)	C21—H21	0.9500
C7—H7A	0.9900	C22—C23	1.401 (3)
C7—H7B	0.9900	C22—C25	1.509 (3)
O8—C25	1.413 (3)	C23—C24	1.388 (4)
O8—H8	0.8400	C23—H23	0.9500
C8—H8A	0.9800	C25—H25A	0.9900
C8—H8B	0.9800	C25—H25B	0.9900
C8—H8C	0.9800	C26—H26A	0.9800
C9—C10	1.503 (4)	C26—H26B	0.9800
C9—H9A	0.9900	C26—H26C	0.9800
C4—O1—C9	117.7 (2)	C12—C13—H13	119.8
C6—C1—C2	118.4 (2)	C14—C13—H13	119.8
C6—C1—C7	121.0 (3)	C15—C14—C13	119.7 (3)
C2—C1—C7	120.5 (2)	C15—C14—C16	117.7 (3)
C3—O2—C8	116.9 (2)	C13—C14—C16	122.6 (3)
C3—C2—C1	121.4 (2)	C14—C15—C10	120.3 (3)
C3—C2—H2	119.3	C14—C15—H15	119.8
C1—C2—H2	119.3	C10—C15—H15	119.8
C7—O3—H3	109.5	O4—C16—O5	123.3 (3)
O2—C3—C2	125.1 (2)	O4—C16—C14	125.1 (3)
O2—C3—C4	115.4 (2)	O5—C16—C14	111.6 (3)
C2—C3—C4	119.5 (3)	O5—C17—H17A	109.5
O1—C4—C5	125.8 (2)	O5—C17—H17B	109.5
O1—C4—C3	114.9 (2)	H17A—C17—H17B	109.5
C5—C4—C3	119.3 (2)	O5—C17—H17C	109.5
C16—O5—C17	112.9 (3)	H17A—C17—H17C	109.5
C4—C5—C6	119.9 (2)	H17B—C17—H17C	109.5
C4—C5—H5	120.0	O6—C18—C12	113.4 (2)
C6—C5—H5	120.0	O6—C18—H18A	108.9
C19—O6—C18	117.38 (19)	C12—C18—H18A	108.9
C1—C6—C5	121.4 (3)	O6—C18—H18B	108.9
C1—C6—H6	119.3	C12—C18—H18B	108.9
C5—C6—H6	119.3	H18A—C18—H18B	107.7
C24—O7—C26	116.3 (2)	C20—C19—O6	125.7 (2)
O3—C7—C1	110.5 (2)	C20—C19—C24	119.6 (2)
O3—C7—H7A	109.5	O6—C19—C24	114.6 (2)
C1—C7—H7A	109.5	C19—C20—C21	121.0 (2)
O3—C7—H7B	109.5	C19—C20—H20	119.5
C1—C7—H7B	109.5	C21—C20—H20	119.5
H7A—C7—H7B	108.1	C22—C21—C20	120.2 (2)
C25—O8—H8	109.5	C22—C21—H21	119.9
O2—C8—H8A	109.5	C20—C21—H21	119.9
O2—C8—H8B	109.5	C21—C22—C23	118.7 (3)
H8A—C8—H8B	109.5	C21—C22—C25	122.7 (2)
O2—C8—H8C	109.5	C23—C22—C25	118.6 (2)
H8A—C8—H8C	109.5	C24—C23—C22	121.4 (2)
H8B—C8—H8C	109.5	C24—C23—H23	119.3
O1—C9—C10	108.8 (2)	C22—C23—H23	119.3
O1—C9—H9A	109.9	O7—C24—C23	124.9 (2)
C10—C9—H9A	109.9	O7—C24—C19	116.1 (2)
O1—C9—H9B	109.9	C23—C24—C19	119.0 (2)
C10—C9—H9B	109.9	O8—C25—C22	111.7 (2)
H9A—C9—H9B	108.3	O8—C25—H25A	109.3
C11—C10—C15	119.4 (3)	C22—C25—H25A	109.3
C11—C10—C9	121.0 (2)	O8—C25—H25B	109.3
C15—C10—C9	119.5 (2)	C22—C25—H25B	109.3
C10—C11—C12	121.0 (2)	H25A—C25—H25B	107.9
C10—C11—H11	119.5	O7—C26—H26A	109.5
C12—C11—H11	119.5	O7—C26—H26B	109.5
C13—C12—C11	119.2 (2)	H26A—C26—H26B	109.5
C13—C12—C18	120.6 (2)	O7—C26—H26C	109.5
C11—C12—C18	120.1 (2)	H26A—C26—H26C	109.5
C12—C13—C14	120.4 (3)	H26B—C26—H26C	109.5
C6—C1—C2—C3	0.5 (4)	C16—C14—C15—C10	178.8 (2)
C7—C1—C2—C3	178.9 (3)	C11—C10—C15—C14	−1.8 (4)
C8—O2—C3—C2	17.4 (4)	C9—C10—C15—C14	175.6 (2)
C8—O2—C3—C4	−161.8 (2)	C17—O5—C16—O4	0.3 (4)
C1—C2—C3—O2	−179.3 (2)	C17—O5—C16—C14	179.8 (2)
C1—C2—C3—C4	−0.1 (4)	C15—C14—C16—O4	−5.0 (4)
C9—O1—C4—C5	−6.5 (4)	C13—C14—C16—O4	173.5 (3)
C9—O1—C4—C3	173.5 (2)	C15—C14—C16—O5	175.5 (2)
O2—C3—C4—O1	−1.3 (3)	C13—C14—C16—O5	−6.0 (4)
C2—C3—C4—O1	179.4 (2)	C19—O6—C18—C12	77.3 (3)
O2—C3—C4—C5	178.7 (2)	C13—C12—C18—O6	−141.4 (2)
C2—C3—C4—C5	−0.6 (4)	C11—C12—C18—O6	42.5 (3)
O1—C4—C5—C6	−179.1 (2)	C18—O6—C19—C20	−6.0 (4)
C3—C4—C5—C6	1.0 (4)	C18—O6—C19—C24	174.4 (2)
C2—C1—C6—C5	−0.2 (4)	O6—C19—C20—C21	179.1 (3)
C7—C1—C6—C5	−178.6 (2)	C24—C19—C20—C21	−1.3 (4)
C4—C5—C6—C1	−0.5 (4)	C19—C20—C21—C22	−1.0 (4)
C6—C1—C7—O3	−130.8 (3)	C20—C21—C22—C23	2.2 (4)
C2—C1—C7—O3	50.8 (3)	C20—C21—C22—C25	−178.1 (3)
C4—O1—C9—C10	177.9 (2)	C21—C22—C23—C24	−1.3 (4)
O1—C9—C10—C11	−17.5 (3)	C25—C22—C23—C24	179.0 (3)
O1—C9—C10—C15	165.2 (2)	C26—O7—C24—C23	−6.2 (4)
C15—C10—C11—C12	2.1 (4)	C26—O7—C24—C19	172.0 (3)
C9—C10—C11—C12	−175.3 (2)	C22—C23—C24—O7	177.2 (2)
C10—C11—C12—C13	−0.7 (4)	C22—C23—C24—C19	−0.9 (4)
C10—C11—C12—C18	175.5 (2)	C20—C19—C24—O7	−176.1 (2)
C11—C12—C13—C14	−0.9 (4)	O6—C19—C24—O7	3.5 (3)
C18—C12—C13—C14	−177.1 (2)	C20—C19—C24—C23	2.2 (4)
C12—C13—C14—C15	1.1 (4)	O6—C19—C24—C23	−178.1 (2)
C12—C13—C14—C16	−177.4 (2)	C21—C22—C25—O8	16.9 (4)
C13—C14—C15—C10	0.2 (4)	C23—C22—C25—O8	−163.4 (2)

D—H···A	D—H	H···A	D···A	D—H···A
O3—H3···O8i	0.84	1.90	2.731 (3)	170
O8—H8···O3ii	0.84	1.90	2.721 (3)	167

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O3—H3⋯O8i	0.84	1.90	2.731 (3)	170
O8—H8⋯O3ii	0.84	1.90	2.721 (3)	167

Symmetry codes: (i) ; (ii) .