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Literature DB >> 2157991

Ontogeny of binding sites for [3H] kainic acid in chick and rat cerebellar membranes: a comparative study.

Abstract

We have analyzed the developmental properties of kainate receptors in cerebellar membranes prepared from chick and rat, two vertebrate species with contrasting patterns of functional maturation. Single populations of binding sites have been characterized in the avian and rodent membranes with apparent dissociation constants (Kd) in the 210-280 nM and 40-55 nM ranges, respectively; the number of binding sites (Bmax) increases with age in both species, reaching a maximum of 187 pmol/mg in the case of 10-day chicks vs. 1.28 pmol/mg in 75-day rats. The ontogenetic profiles of kainate receptors in chick and rat cerebella are in consonance with the patent differences in motor development at birth.

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Year: 1990 PMID： 2157991 DOI： 10.1007/BF00969183

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

23 in total

1. The GABA(a) receptor complex in the developing chick optic tectum: Ontogeny of [(3)H]muscimol, [(3)H]flunitrazepam and [(35)S]TBPS binding sites.

Authors: A Batuecas; A Cubero; A Barat; G Ramírez
Journal: Neurochem Int Date: 1987 Impact factor: 3.921

2. The binding properties and regional ontogeny for [3H]glutamic acid Na+-independent and [3H]kainic acid binding sites in chick brain.

Authors: G Voukelatou; F Angelatoy; E D Kouvelas
Journal: Int J Dev Neurosci Date: 1986 Impact factor: 2.457

3. Localization of receptors for kainic acid on neurons in the innernuclear layer of retina.

Authors: K Biziere; J T Coyle
Journal: Neuropharmacology Date: 1979-04 Impact factor: 5.250

Review 4. The physiology of excitatory amino acids in the vertebrate central nervous system.

Authors: M L Mayer; G L Westbrook
Journal: Prog Neurobiol Date: 1987 Impact factor: 11.685

5. Ontogenesis of GABA receptor sites in chick embryo cerebellum.

Authors: S Fiszer De Plazas
Journal: Brain Res Date: 1982-02 Impact factor: 3.252

6. Development of specific binding sites for [3H]kainic acid and [3H]muscimol in the chick optic tectum: modulation by early changes in visual input.

Authors: G Ramírez; A Barat; J Gómez-Barriocanal; E Manrique; A Batuecas
Journal: Adv Biochem Psychopharmacol Date: 1983

Ontogeny of binding sites for [3H] kainic acid in chick and rat cerebellar membranes: a comparative study.

1. The GABA(a) receptor complex in the developing chick optic tectum: Ontogeny of [(3)H]muscimol, [(3)H]flunitrazepam and [(35)S]TBPS binding sites.

2. The binding properties and regional ontogeny for [3H]glutamic acid Na+-independent and [3H]kainic acid binding sites in chick brain.

3. Localization of receptors for kainic acid on neurons in the innernuclear layer of retina.

Review 4. The physiology of excitatory amino acids in the vertebrate central nervous system.

5. Ontogenesis of GABA receptor sites in chick embryo cerebellum.

6. Development of specific binding sites for [3H]kainic acid and [3H]muscimol in the chick optic tectum: modulation by early changes in visual input.

7. Genetic and 'epigenetic' factors regulating synapse formation in vertebrate cerebellum and neuromuscular junction.

8. Ontogeny of receptor binding sites for [3H]glutamic acid and [3H]kainic acid in the rat cerebellum.

9. Electrophysiological study on the postnatal development of neuronal mechanisms in the rat cerebellar cortex.

10. Phylogenetic distribution of [3H]kainic acid receptor binding sites in neuronal tissue.

1. In vitro characterization of gamma oscillations in the hippocampal formation of the domestic chick.