[1-(Carboxy-meth-yl)cyclo-hexyl]-methan-aminium dihydrogen phosphate.

In the title salt, C(9)H(18)NO(2) (+)·H(2)PO(4) (-), the cyclo-hexane ring is puckered, the total puckering amplitude Q(T) being 0.555 (4) Å, and an intra-molecular N-H⋯O hydrogen bond generates an S(7) ring. In the crystal structure, inter-molecular N-H⋯O and O-H⋯O hydrogen bonds lead to R(2) (2)(14), R(3) (3)(8) and R(4) (2)(8) rings, generating a two-dimensional layer.

Related literature

For related structures and medicinal background, see: Reece & Levendis (2008 ▶); Ibers (2001 ▶). For the graph-set analysis of hydrogen-bond patterns, see: Bernstein et al. (1995 ▶). For details of ring-puckering analysis, see: Cremer & Pople (1975 ▶). For bond-valence analysis and the positioning of H atoms, see: Brese & O’Keeffe (1991 ▶).

Experimental

Crystal data

C9H18NO2 +·H2O4P−

M = 269.23

Orthorhombic,

a = 10.473 (5) Å

b = 9.269 (3) Å

c = 26.468 (5) Å

V = 2569.4 (16) Å3

Z = 8

Mo Kα radiation

μ = 0.23 mm−1

T = 296 K

0.31 × 0.25 × 0.22 mm

Data collection

Bruker Kappa APEXII CCD diffractometer

14659 measured reflections

3185 independent reflections

1853 reflections with I > 2σ(I)

R int = 0.071

Refinement

R[F 2 > 2σ(F 2)] = 0.051

wR(F 2) = 0.155

S = 1.06

3185 reflections

178 parameters

6 restraints

H atoms treated by a mixture of independent and constrained refinement

Δρmax = 0.34 e Å−3

Δρmin = −0.45 e Å−3

Data collection: APEX2 (Bruker, 2009 ▶); cell refinement: SAINT (Bruker, 2009 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997 ▶); software used to prepare material for publication: WinGX (Farrugia, 1999 ▶).

Crystal structure: contains datablocks global, I. DOI: 10.1107/S1600536810012973/hb5398sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536810012973/hb5398Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C9H18NO2+·H2O4P−	F(000) = 1152
Mr = 269.23	Dx = 1.392 Mg m−3
Orthorhombic, Pbca	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ac 2ab	Cell parameters from 1923 reflections
a = 10.473 (5) Å	θ = 3.0–21.6°
b = 9.269 (3) Å	µ = 0.23 mm−1
c = 26.468 (5) Å	T = 296 K
V = 2569.4 (16) Å3	Prism, colourless
Z = 8	0.31 × 0.25 × 0.22 mm

Bruker Kappa APEXII CCD diffractometer	1853 reflections with I > 2σ(I)
Radiation source: fine-focus sealed tube	Rint = 0.071
graphite	θmax = 28.3°, θmin = 1.5°
φ and ω scans	h = −13→7
14659 measured reflections	k = −11→12
3185 independent reflections	l = −35→35

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.051	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.155	H atoms treated by a mixture of independent and constrained refinement
S = 1.06	w = 1/[σ2(Fo2) + (0.0712P)2] where P = (Fo2 + 2Fc2)/3
3185 reflections	(Δ/σ)max < 0.001
178 parameters	Δρmax = 0.34 e Å−3
6 restraints	Δρmin = −0.45 e Å−3

Geometry. All esds (except the esd in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell esds are taken into account individually in the estimation of esds in distances, angles and torsion angles; correlations between esds in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell esds is used for estimating esds involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
C1	0.6575 (4)	0.1582 (5)	0.67421 (15)	0.0667 (12)
H1A	0.6569	0.2315	0.6481	0.080*
H1B	0.7457	0.1334	0.6812	0.080*
C2	0.5874 (3)	0.0253 (4)	0.65538 (12)	0.0413 (8)
H2A	0.5967	−0.0514	0.6801	0.050*
H2B	0.6266	−0.0070	0.6242	0.050*
C3	0.4441 (3)	0.0522 (3)	0.64599 (10)	0.0301 (7)
C4	0.3859 (4)	0.1206 (4)	0.69378 (12)	0.0477 (9)
H4A	0.2983	0.1474	0.6866	0.057*
H4B	0.3842	0.0485	0.7204	0.057*
C5	0.4563 (4)	0.2527 (4)	0.71319 (15)	0.0667 (12)
H5A	0.4489	0.3303	0.6888	0.080*
H5B	0.4178	0.2847	0.7446	0.080*
C6	0.5961 (5)	0.2189 (6)	0.72201 (16)	0.0874 (16)
H6A	0.6039	0.1492	0.7492	0.105*
H6B	0.6406	0.3061	0.7321	0.105*
C7	0.4205 (3)	0.1584 (3)	0.60270 (11)	0.0329 (7)
H7A	0.3293	0.1639	0.5966	0.040*
H7B	0.4487	0.2533	0.6133	0.040*
C8	0.3736 (3)	−0.0923 (3)	0.63691 (13)	0.0445 (9)
H8A	0.3624	−0.1395	0.6693	0.053*
H8B	0.2891	−0.0705	0.6239	0.053*
C9	0.4354 (3)	−0.1977 (3)	0.60166 (12)	0.0343 (7)
N1	0.4845 (2)	0.1225 (3)	0.55463 (9)	0.0296 (6)
H3	0.5685 (19)	0.141 (4)	0.5561 (14)	0.067 (12)*
H4	0.473 (4)	0.027 (2)	0.5469 (13)	0.069 (13)*
H5	0.454 (3)	0.173 (4)	0.5291 (11)	0.066 (12)*
O5	0.4571 (2)	−0.1736 (2)	0.55742 (8)	0.0417 (6)
O6	0.4610 (3)	−0.3214 (3)	0.62334 (10)	0.0537 (7)
H6	0.500 (4)	−0.373 (4)	0.6027 (13)	0.085 (15)*
O1	0.8667 (2)	0.1053 (2)	0.47674 (8)	0.0366 (5)
H1	0.929 (3)	0.066 (4)	0.4646 (16)	0.091 (16)*
O2	0.7236 (2)	−0.0726 (2)	0.51893 (10)	0.0413 (6)
H2	0.739 (5)	−0.149 (3)	0.5316 (16)	0.102 (18)*
O3	0.92807 (17)	−0.00007 (19)	0.56151 (7)	0.0279 (5)
O4	0.74292 (18)	0.17523 (19)	0.55177 (8)	0.0324 (5)
P1	0.81774 (6)	0.05253 (7)	0.52950 (3)	0.0242 (2)

	U11	U22	U33	U12	U13	U23
C1	0.050 (2)	0.093 (3)	0.057 (2)	−0.009 (2)	−0.0153 (19)	−0.020 (2)
C2	0.0434 (18)	0.050 (2)	0.0308 (17)	0.0091 (16)	−0.0039 (14)	0.0055 (15)
C3	0.0353 (15)	0.0273 (16)	0.0277 (16)	0.0039 (13)	0.0068 (13)	−0.0017 (12)
C4	0.064 (2)	0.045 (2)	0.0339 (19)	0.0084 (18)	0.0157 (17)	−0.0015 (16)
C5	0.094 (3)	0.063 (3)	0.043 (2)	0.002 (2)	0.006 (2)	−0.0247 (19)
C6	0.101 (4)	0.106 (4)	0.055 (3)	−0.017 (3)	−0.016 (3)	−0.035 (3)
C7	0.0310 (15)	0.0361 (18)	0.0317 (16)	0.0113 (13)	0.0044 (13)	0.0009 (13)
C8	0.0446 (19)	0.0364 (19)	0.052 (2)	−0.0021 (15)	0.0225 (17)	−0.0022 (15)
C9	0.0320 (16)	0.0271 (17)	0.044 (2)	−0.0051 (13)	0.0077 (14)	−0.0016 (14)
N1	0.0291 (14)	0.0331 (16)	0.0265 (14)	0.0046 (12)	0.0017 (11)	0.0030 (12)
O5	0.0501 (14)	0.0350 (13)	0.0399 (14)	0.0027 (10)	0.0078 (11)	−0.0013 (10)
O6	0.0788 (18)	0.0353 (15)	0.0471 (15)	0.0119 (13)	0.0221 (14)	0.0026 (12)
O1	0.0325 (11)	0.0383 (12)	0.0391 (13)	0.0121 (10)	0.0096 (10)	0.0117 (10)
O2	0.0331 (11)	0.0184 (12)	0.0724 (17)	−0.0029 (9)	−0.0180 (11)	0.0081 (11)
O3	0.0233 (9)	0.0249 (10)	0.0356 (11)	0.0022 (8)	0.0001 (8)	0.0001 (9)
O4	0.0273 (10)	0.0182 (10)	0.0516 (13)	0.0048 (8)	0.0121 (9)	0.0033 (9)
P1	0.0193 (3)	0.0157 (4)	0.0377 (4)	0.0022 (3)	0.0025 (3)	0.0031 (3)

C1—C2	1.519 (5)	C7—N1	1.476 (4)
C1—C6	1.526 (6)	C7—H7A	0.9700
C1—H1A	0.9700	C7—H7B	0.9700
C1—H1B	0.9700	C8—C9	1.498 (4)
C2—C3	1.541 (4)	C8—H8A	0.9700
C2—H2A	0.9700	C8—H8B	0.9700
C2—H2B	0.9700	C9—O5	1.213 (3)
C3—C7	1.531 (4)	C9—O6	1.310 (4)
C3—C4	1.541 (4)	N1—H3	0.897 (18)
C3—C8	1.549 (4)	N1—H4	0.912 (18)
C4—C5	1.519 (5)	N1—H5	0.881 (18)
C4—H4A	0.9700	O6—H6	0.83 (4)
C4—H4B	0.9700	O1—P1	1.566 (2)
C5—C6	1.515 (6)	O1—H1	0.817 (19)
C5—H5A	0.9700	O2—P1	1.548 (2)
C5—H5B	0.9700	O2—H2	0.799 (19)
C6—H6A	0.9700	O3—P1	1.513 (2)
C6—H6B	0.9700	O4—P1	1.502 (2)
C2—C1—C6	111.5 (3)	C5—C6—H6B	109.5
C2—C1—H1A	109.3	C1—C6—H6B	109.5
C6—C1—H1A	109.3	H6A—C6—H6B	108.1
C2—C1—H1B	109.3	N1—C7—C3	115.2 (2)
C6—C1—H1B	109.3	N1—C7—H7A	108.5
H1A—C1—H1B	108.0	C3—C7—H7A	108.5
C1—C2—C3	113.1 (3)	N1—C7—H7B	108.5
C1—C2—H2A	109.0	C3—C7—H7B	108.5
C3—C2—H2A	109.0	H7A—C7—H7B	107.5
C1—C2—H2B	109.0	C9—C8—C3	117.0 (2)
C3—C2—H2B	109.0	C9—C8—H8A	108.0
H2A—C2—H2B	107.8	C3—C8—H8A	108.0
C7—C3—C2	112.5 (2)	C9—C8—H8B	108.0
C7—C3—C4	106.6 (2)	C3—C8—H8B	108.0
C2—C3—C4	108.6 (3)	H8A—C8—H8B	107.3
C7—C3—C8	111.3 (3)	O5—C9—O6	123.0 (3)
C2—C3—C8	110.5 (3)	O5—C9—C8	124.2 (3)
C4—C3—C8	107.1 (2)	O6—C9—C8	112.7 (3)
C5—C4—C3	114.7 (3)	C7—N1—H3	111 (2)
C5—C4—H4A	108.6	C7—N1—H4	111 (2)
C3—C4—H4A	108.6	H3—N1—H4	109 (3)
C5—C4—H4B	108.6	C7—N1—H5	112 (2)
C3—C4—H4B	108.6	H3—N1—H5	107 (3)
H4A—C4—H4B	107.6	H4—N1—H5	107 (3)
C6—C5—C4	110.7 (3)	C9—O6—H6	109 (3)
C6—C5—H5A	109.5	P1—O1—H1	118 (3)
C4—C5—H5A	109.5	P1—O2—H2	118 (3)
C6—C5—H5B	109.5	O4—P1—O3	115.00 (12)
C4—C5—H5B	109.5	O4—P1—O2	107.84 (12)
H5A—C5—H5B	108.1	O3—P1—O2	110.23 (12)
C5—C6—C1	110.8 (3)	O4—P1—O1	106.50 (11)
C5—C6—H6A	109.5	O3—P1—O1	110.49 (12)
C1—C6—H6A	109.5	O2—P1—O1	106.35 (14)
C6—C1—C2—C3	55.9 (4)	C2—C1—C6—C5	−56.5 (5)
C1—C2—C3—C7	65.8 (4)	C2—C3—C7—N1	53.0 (4)
C1—C2—C3—C4	−51.9 (4)	C4—C3—C7—N1	172.0 (3)
C1—C2—C3—C8	−169.2 (3)	C8—C3—C7—N1	−71.5 (3)
C7—C3—C4—C5	−69.4 (4)	C7—C3—C8—C9	80.2 (3)
C2—C3—C4—C5	52.0 (4)	C2—C3—C8—C9	−45.5 (4)
C8—C3—C4—C5	171.4 (3)	C4—C3—C8—C9	−163.7 (3)
C3—C4—C5—C6	−54.9 (4)	C3—C8—C9—O5	−61.3 (4)
C4—C5—C6—C1	55.2 (5)	C3—C8—C9—O6	120.4 (3)

D—H···A	D—H	H···A	D···A	D—H···A
O6—H6···O3i	0.83 (4)	1.77 (2)	2.602 (3)	173 (4)
O1—H1···O3ii	0.82 (2)	1.76 (2)	2.569 (3)	173 (5)
N1—H5···O1iii	0.88 (2)	2.26 (3)	2.929 (4)	133 (3)
N1—H5···O2iv	0.88 (2)	2.44 (3)	2.959 (3)	118 (3)
N1—H5···O5iv	0.88 (2)	2.47 (3)	3.065 (3)	125 (3)
N1—H4···O5	0.91 (2)	1.89 (2)	2.760 (4)	158 (3)
N1—H3···O4	0.90 (2)	1.86 (2)	2.752 (3)	174 (3)

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O6—H6⋯O3i	0.83 (4)	1.77 (2)	2.602 (3)	173 (4)
O1—H1⋯O3ii	0.82 (2)	1.76 (2)	2.569 (3)	173 (5)
N1—H5⋯O1iii	0.88 (2)	2.26 (3)	2.929 (4)	133 (3)
N1—H5⋯O2iv	0.88 (2)	2.44 (3)	2.959 (3)	118 (3)
N1—H5⋯O5iv	0.88 (2)	2.47 (3)	3.065 (3)	125 (3)
N1—H4⋯O5	0.91 (2)	1.89 (2)	2.760 (4)	158 (3)
N1—H3⋯O4	0.90 (2)	1.86 (2)	2.752 (3)	174 (3)

Symmetry codes: (i) ; (ii) ; (iii) ; (iv) .