Literature DB >> 2157893

Phytohemagglutinin-induced activity of cyclic AMP (cAMP) response elements from cytomegalovirus is reduced by cyclosporine and synergistically enhanced by cAMP.

H H Niller1, L Hennighausen.   

Abstract

The 19-base-pair enhancer repeat of the human cytomegalovirus immediate-early 1 gene mediates cyclic AMP- and phytohemagglutinin-induced expression in Jurkat T cells. Synergistic activity was observed in the presence of both drugs, suggesting a convergence of the protein kinase A and C pathways on this transcription element. In addition, the immunosuppressive drug cyclosporine strongly reduced the ability of the 19-base-pair repeat to activate gene expression in phytohemagglutinin-stimulated T cells.

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Year:  1990        PMID： 2157893      PMCID： PMC249401          DOI： 10.1128/JVI.64.5.2388-2391.1990

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  43 in total

1.  Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP.

Authors:  M Imagawa; R Chiu; M Karin
Journal:  Cell       Date:  1987-10-23       Impact factor: 41.582

2.  Binding of transcription factors and creation of a large nucleoprotein complex on the human cytomegalovirus enhancer.

Authors:  P Ghazal; H Lubon; B Fleckenstein; L Hennighausen
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

3.  Activation of the HIV-1 LTR by T cell mitogens and the trans-activator protein of HTLV-I.

Authors:  M Siekevitz; S F Josephs; M Dukovich; N Peffer; F Wong-Staal; W C Greene
Journal:  Science       Date:  1987-12-11       Impact factor: 47.728

4.  Selection and characterization of T-cell variants lacking molecules involved in T-cell activation (T3 T-cell receptor, T44, and T11): analysis of the functional relationship among different pathways of activation.

Authors:  A Moretta; A Poggi; D Olive; C Bottino; C Fortis; G Pantaleo; L Moretta
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

5.  Interaction of protein with DNA in vitro.

Authors:  L Hennighausen; H Lubon
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

6.  Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.

Authors:  P Angel; M Imagawa; R Chiu; B Stein; R J Imbra; H J Rahmsdorf; C Jonat; P Herrlich; M Karin
Journal:  Cell       Date:  1987-06-19       Impact factor: 41.582

7.  An inducible transcription factor activates expression of human immunodeficiency virus in T cells.

Authors:  G Nabel; D Baltimore
Journal:  Nature       Date:  1987 Apr 16-22       Impact factor: 49.962

8.  The palindromic series I repeats in the simian cytomegalovirus major immediate-early promoter behave as both strong basal enhancers and cyclic AMP response elements.

Authors:  Y N Chang; S Crawford; J Stall; D R Rawlins; K T Jeang; G S Hayward
Journal:  J Virol       Date:  1990-01       Impact factor: 5.103

9.  Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation.

Authors:  E A Emmel; C L Verweij; D B Durand; K M Higgins; E Lacy; G R Crabtree
Journal:  Science       Date:  1989-12-22       Impact factor: 47.728

10.  Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.

Authors:  M R Montminy; L M Bilezikjian
Journal:  Nature       Date:  1987 Jul 9-15       Impact factor: 49.962
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  12 in total

1.  Formation of several specific nucleoprotein complexes on the human cytomegalovirus immediate early enhancer.

Authors:  H H Niller; L Hennighausen
Journal:  Nucleic Acids Res       Date:  1991-07-11       Impact factor: 16.971

2.  Enhancement of RNA polymerase II initiation complexes by a novel DNA control domain downstream from the cap site of the cytomegalovirus major immediate-early promoter.

Authors:  P Ghazal; J A Nelson
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

3.  The enhancer domain of the human cytomegalovirus major immediate-early promoter determines cell type-specific expression in transgenic mice.

Authors:  J F Baskar; P P Smith; G Nilaver; R A Jupp; S Hoffmann; N J Peffer; D J Tenney; A M Colberg-Poley; P Ghazal; J A Nelson
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

4.  Developmental analysis of the cytomegalovirus enhancer in transgenic animals.

Authors:  J F Baskar; P P Smith; G S Ciment; S Hoffmann; C Tucker; D J Tenney; A M Colberg-Poley; J A Nelson; P Ghazal
Journal:  J Virol       Date:  1996-05       Impact factor: 5.103

5.  The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1.

Authors:  S S Banerji; J N Parsons; M J Tocci
Journal:  Mol Cell Biol       Date:  1991-08       Impact factor: 4.272

6.  Longitudinal, noninvasive imaging of T-cell effector function and proliferation in living subjects.

Authors:  Manishkumar R Patel; Ya-Fang Chang; Ian Y Chen; Michael H Bachmann; Xinrui Yan; Christopher H Contag; Sanjiv S Gambhir
Journal:  Cancer Res       Date:  2010-12-15       Impact factor: 12.701

7.  Strong trans activation of the human cytomegalovirus major immediate-early enhancer by p40tax of human T-cell leukemia virus type I via two repetitive tax-responsive sequence elements.

Authors:  H Moch; D Lang; T Stamminger
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

8.  The variability in activity of the universally expressed human cytomegalovirus immediate early gene 1 enhancer/promoter in transgenic mice.

Authors:  P A Furth; L Hennighausen; C Baker; B Beatty; R Woychick
Journal:  Nucleic Acids Res       Date:  1991-11-25       Impact factor: 16.971

9.  Modulation of T-cell activation through protein kinase C- or A-dependent signalling pathways synergistically increases human immunodeficiency virus long terminal repeat induction by cytomegalovirus immediate-early proteins.

Authors:  C V Paya; J L Virelizier; S Michelson
Journal:  J Virol       Date:  1991-10       Impact factor: 5.103

10.  Expression of protein kinase A and protein kinase C during ongoing human cytomegalovirus infection.

Authors:  A K Kristoffersen; K Taskèn; H Rollag
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574
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