1,2-Bis(bromo-meth-yl)-4,5-dimethoxy-benzene.

Colourless crystals of the title compound, C(10)H(12)Br(2)O(2), were synthesized from 1,2-dimethoxy-benzene. The crystal structure is stabilized by inter-molecular C-H⋯O hydrogen bonds.

Related literature

For the use of the title compound in the preparation of crown ether derivatives and isoindoline compounds, see: Dalence-Guzman et al. (2008 ▶); Diederich et al. (1993 ▶); Walpole et al. (1994 ▶).

Experimental

Crystal data

C10H12Br2O2

M = 324.00

Orthorhombic,

a = 8.125 (6) Å

b = 14.689 (10) Å

c = 20.353 (13) Å

V = 2429 (3) Å3

Z = 8

Mo Kα radiation

μ = 6.65 mm−1

T = 153 K

0.15 × 0.10 × 0.10 mm

Data collection

Bruker APEXII CCD area-detector diffractometer

Absorption correction: multi-scan (SADABS; Bruker, 2005 ▶) T min = 0.456, T max = 0.516

12237 measured reflections

2475 independent reflections

1643 reflections with I > 2σ(I)

R int = 0.043

Refinement

R[F 2 > 2σ(F 2)] = 0.040

wR(F 2) = 0.117

S = 1.02

2475 reflections

129 parameters

H-atom parameters constrained

Δρmax = 0.89 e Å−3

Δρmin = −0.72 e Å−3

Data collection: APEX2 (Bruker, 2005 ▶); cell refinement: SAINT (Bruker, 2005 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: ORTEP-3 for Windows (Farrugia, 1997 ▶); software used to prepare material for publication: WinGX (Farrugia, 1999 ▶).

Crystal structure: contains datablocks I, global. DOI: 10.1107/S1600536809030001/jh2086sup1.cif

Structure factors: contains datablocks I. DOI: 10.1107/S1600536809030001/jh2086Isup2.hkl

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C10H12Br2O2	F(000) = 1264
Mr = 324.00	Dx = 1.772 Mg m−3
Orthorhombic, Pbca	Mo Kα radiation, λ = 0.71073 Å
Hall symbol: -P 2ac 2ab	Cell parameters from 2795 reflections
a = 8.125 (6) Å	θ = 2.8–22.0°
b = 14.689 (10) Å	µ = 6.65 mm−1
c = 20.353 (13) Å	T = 153 K
V = 2429 (3) Å3	Prism, colourless
Z = 8	0.15 × 0.10 × 0.10 mm

Bruker APEXII CCD area-detector diffractometer	2475 independent reflections
Radiation source: fine-focus sealed tube	1643 reflections with I > 2σ(I)
graphite	Rint = 0.043
φ and ω scans	θmax = 26.4°, θmin = 2.0°
Absorption correction: multi-scan (SADABS; Bruker, 2005)	h = −10→6
Tmin = 0.456, Tmax = 0.516	k = −18→17
12237 measured reflections	l = −25→20

Refinement on F2	Primary atom site location: structure-invariant direct methods
Least-squares matrix: full	Secondary atom site location: difference Fourier map
R[F2 > 2σ(F2)] = 0.040	Hydrogen site location: inferred from neighbouring sites
wR(F2) = 0.117	H-atom parameters constrained
S = 1.01	w = 1/[σ2(Fo2) + (0.0542P)2 + 2.9265P] where P = (Fo2 + 2Fc2)/3
2475 reflections	(Δ/σ)max < 0.001
129 parameters	Δρmax = 0.89 e Å−3
0 restraints	Δρmin = −0.72 e Å−3

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
Br1	0.41088 (8)	0.58977 (4)	0.08751 (3)	0.0691 (2)
Br2	−0.16982 (8)	0.43548 (4)	0.13229 (3)	0.0720 (2)
C1	0.3186 (6)	0.2549 (3)	0.1807 (2)	0.0410 (10)
O2	0.3599 (4)	0.1778 (2)	0.21493 (15)	0.0514 (8)
C2	0.4121 (6)	0.2681 (3)	0.12203 (19)	0.0385 (10)
C3	0.1717 (6)	0.3963 (3)	0.1603 (2)	0.0443 (10)
O1	0.5203 (4)	0.1999 (2)	0.10678 (14)	0.0549 (9)
C4	0.2023 (6)	0.3175 (3)	0.1981 (2)	0.0438 (10)
H4	0.1399	0.3077	0.2370	0.053*
C5	0.3861 (6)	0.3470 (3)	0.0855 (2)	0.0428 (10)
H5	0.4500	0.3574	0.0471	0.051*
C8	0.0391 (7)	0.4600 (3)	0.1814 (2)	0.0568 (13)
H8A	0.0745	0.5235	0.1733	0.068*
H8B	0.0194	0.4529	0.2291	0.068*
C7	0.2466 (7)	0.4960 (3)	0.0628 (2)	0.0554 (12)
H7A	0.1343	0.5206	0.0689	0.067*
H7B	0.2602	0.4801	0.0158	0.067*
C6	0.2675 (6)	0.4116 (3)	0.1043 (2)	0.0441 (11)
C10	0.2760 (7)	0.1627 (4)	0.2764 (3)	0.0681 (16)
H10A	0.2901	0.2159	0.3048	0.102*
H10B	0.3222	0.1088	0.2980	0.102*
H10C	0.1585	0.1529	0.2680	0.102*
C20	0.6114 (8)	0.2081 (4)	0.0474 (3)	0.0712 (16)
H20A	0.5362	0.2043	0.0098	0.107*
H20B	0.6923	0.1588	0.0447	0.107*
H20C	0.6684	0.2669	0.0467	0.107*

	U11	U22	U33	U12	U13	U23
Br1	0.0821 (5)	0.0486 (3)	0.0765 (4)	−0.0146 (3)	0.0161 (3)	0.0010 (2)
Br2	0.0562 (4)	0.0688 (4)	0.0911 (5)	0.0108 (3)	−0.0137 (3)	−0.0024 (3)
C1	0.048 (3)	0.035 (2)	0.040 (2)	0.002 (2)	−0.0024 (19)	0.0038 (18)
O2	0.051 (2)	0.0500 (18)	0.0532 (18)	0.0134 (15)	0.0079 (15)	0.0175 (14)
C2	0.034 (2)	0.040 (2)	0.042 (2)	0.0025 (19)	−0.0016 (19)	−0.0022 (18)
C3	0.046 (3)	0.036 (2)	0.051 (3)	0.002 (2)	−0.008 (2)	−0.0076 (19)
O1	0.062 (2)	0.0549 (19)	0.0474 (17)	0.0175 (18)	0.0145 (16)	0.0053 (15)
C4	0.050 (3)	0.043 (2)	0.039 (2)	0.001 (2)	0.000 (2)	−0.0005 (18)
C5	0.042 (3)	0.048 (2)	0.038 (2)	−0.003 (2)	−0.003 (2)	0.0009 (19)
C8	0.063 (3)	0.041 (3)	0.067 (3)	0.008 (2)	−0.008 (3)	−0.010 (2)
C7	0.058 (3)	0.045 (3)	0.063 (3)	−0.003 (2)	−0.013 (3)	0.011 (2)
C6	0.052 (3)	0.034 (2)	0.046 (2)	−0.003 (2)	−0.006 (2)	0.0016 (19)
C10	0.062 (4)	0.075 (3)	0.068 (3)	0.013 (3)	0.018 (3)	0.031 (3)
C20	0.077 (4)	0.075 (4)	0.062 (3)	0.019 (3)	0.029 (3)	−0.006 (3)

Br1—C7	1.983 (5)	C5—C6	1.405 (6)
Br2—C8	2.002 (5)	C5—H5	0.9500
C1—C4	1.365 (6)	C8—H8A	0.9900
C1—O2	1.372 (5)	C8—H8B	0.9900
C1—C2	1.428 (6)	C7—C6	1.510 (6)
O2—C10	1.442 (6)	C7—H7A	0.9900
C2—O1	1.368 (5)	C7—H7B	0.9900
C2—C5	1.394 (6)	C10—H10A	0.9800
C3—C6	1.399 (6)	C10—H10B	0.9800
C3—C4	1.413 (6)	C10—H10C	0.9800
C3—C8	1.490 (7)	C20—H20A	0.9800
O1—C20	1.422 (6)	C20—H20B	0.9800
C4—H4	0.9500	C20—H20C	0.9800
C4—C1—O2	126.4 (4)	H8A—C8—H8B	108.1
C4—C1—C2	119.7 (4)	C6—C7—Br1	110.6 (3)
O2—C1—C2	114.0 (4)	C6—C7—H7A	109.5
C1—O2—C10	116.9 (4)	Br1—C7—H7A	109.5
O1—C2—C5	125.8 (4)	C6—C7—H7B	109.5
O1—C2—C1	115.7 (3)	Br1—C7—H7B	109.5
C5—C2—C1	118.5 (4)	H7A—C7—H7B	108.1
C6—C3—C4	118.5 (4)	C3—C6—C5	119.7 (4)
C6—C3—C8	122.5 (4)	C3—C6—C7	121.7 (4)
C4—C3—C8	119.0 (4)	C5—C6—C7	118.7 (4)
C2—O1—C20	117.7 (4)	O2—C10—H10A	109.5
C1—C4—C3	122.1 (4)	O2—C10—H10B	109.5
C1—C4—H4	118.9	H10A—C10—H10B	109.5
C3—C4—H4	118.9	O2—C10—H10C	109.5
C2—C5—C6	121.4 (4)	H10A—C10—H10C	109.5
C2—C5—H5	119.3	H10B—C10—H10C	109.5
C6—C5—H5	119.3	O1—C20—H20A	109.5
C3—C8—Br2	110.9 (3)	O1—C20—H20B	109.5
C3—C8—H8A	109.5	H20A—C20—H20B	109.5
Br2—C8—H8A	109.5	O1—C20—H20C	109.5
C3—C8—H8B	109.5	H20A—C20—H20C	109.5
Br2—C8—H8B	109.5	H20B—C20—H20C	109.5
C4—C1—O2—C10	−2.0 (7)	O1—C2—C5—C6	177.7 (4)
C2—C1—O2—C10	177.1 (4)	C1—C2—C5—C6	−2.0 (6)
C4—C1—C2—O1	−177.0 (4)	C6—C3—C8—Br2	82.9 (5)
O2—C1—C2—O1	3.8 (6)	C4—C3—C8—Br2	−97.1 (4)
C4—C1—C2—C5	2.7 (6)	C4—C3—C6—C5	2.6 (6)
O2—C1—C2—C5	−176.5 (4)	C8—C3—C6—C5	−177.4 (4)
C5—C2—O1—C20	−2.2 (7)	C4—C3—C6—C7	−177.6 (4)
C1—C2—O1—C20	177.5 (4)	C8—C3—C6—C7	2.3 (7)
O2—C1—C4—C3	178.3 (4)	C2—C5—C6—C3	−0.7 (7)
C2—C1—C4—C3	−0.8 (7)	C2—C5—C6—C7	179.6 (4)
C6—C3—C4—C1	−1.9 (7)	Br1—C7—C6—C3	96.8 (5)
C8—C3—C4—C1	178.1 (4)	Br1—C7—C6—C5	−83.5 (5)

D—H···A	D—H	H···A	D···A	D—H···A
C8—H8A···O2i	0.99	2.48	3.373 (6)	150
C10—H10C···O2ii	0.98	2.48	3.392 (7)	155

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
C8—H8A⋯O2i	0.99	2.48	3.373 (6)	150
C10—H10C⋯O2ii	0.98	2.48	3.392 (7)	155

Symmetry codes: (i) ; (ii) .