BACKGROUND/AIMS: It is generally accepted that there is a correlation between obesity and poor outcome in acute pancreatitis (AP); however, the relationship between overweight and the prognosis of AP is unknown. The aim of this study was to determine the correlation between overweight and the prognosis of AP. METHODS: MEDLINE and PubMed were searched using the terms 'acute pancreatitis', 'obesity', 'overweight', and 'body mass index' ('BMI'). All prospective clinical studies correlating BMI and AP were included. Obesity and overweight were defined as BMI ≥30 and from 25 to 30, respectively. A meta-analysis was performed with the endpoints severe AP (SAP), local complications, systemic complications, and mortality. RESULTS: Eight studies including 939 patients were found. The incidence rates of SAP (OR 2.48, 95% CI 1.34-4.60), local complications (OR 2.58, 95% CI 1.20-5.57), and mortality (OR 3.81, 95% CI 1.22-11.83) were increased in overweight patients with AP. No difference was detected in the incidence of systemic complications between the normal-weight and overweight patients (OR 1.62, 95% CI 0.76-3.43). In addition, the correlation between obesity and poor prognosis was again confirmed. CONCLUSION: Overweight is an additional prognostic factor of severity, local complications, and mortality in AP. and IAP.
BACKGROUND/AIMS: It is generally accepted that there is a correlation between obesity and poor outcome in acute pancreatitis (AP); however, the relationship between overweight and the prognosis of AP is unknown. The aim of this study was to determine the correlation between overweight and the prognosis of AP. METHODS: MEDLINE and PubMed were searched using the terms 'acute pancreatitis', 'obesity', 'overweight', and 'body mass index' ('BMI'). All prospective clinical studies correlating BMI and AP were included. Obesity and overweight were defined as BMI ≥30 and from 25 to 30, respectively. A meta-analysis was performed with the endpoints severe AP (SAP), local complications, systemic complications, and mortality. RESULTS: Eight studies including 939 patients were found. The incidence rates of SAP (OR 2.48, 95% CI 1.34-4.60), local complications (OR 2.58, 95% CI 1.20-5.57), and mortality (OR 3.81, 95% CI 1.22-11.83) were increased in overweight patients with AP. No difference was detected in the incidence of systemic complications between the normal-weight and overweight patients (OR 1.62, 95% CI 0.76-3.43). In addition, the correlation between obesity and poor prognosis was again confirmed. CONCLUSION: Overweight is an additional prognostic factor of severity, local complications, and mortality in AP. and IAP.
Authors: Katherine F Sweeny; Tom K Lin; Jaimie D Nathan; Lee A Denson; Sohail Z Husain; Lindsey Hornung; Tyler Thompson; Maisam Abu-El-Haija Journal: J Pediatr Gastroenterol Nutr Date: 2019-01 Impact factor: 2.839
Authors: Somashekar G Krishna; Alice Hinton; Veeral Oza; Phil A Hart; Eric Swei; Samer El-Dika; Peter P Stanich; Hisham Hussan; Cheng Zhang; Darwin L Conwell Journal: Am J Gastroenterol Date: 2015-10-20 Impact factor: 10.864
Authors: Jana Katuchova; Juraj Bober; Pavol Harbulak; Alexander Hudak; Tomas Gajdzik; Rastislav Kalanin; Jozef Radonak Journal: Wien Klin Wochenschr Date: 2014-02-13 Impact factor: 1.704
Authors: T C Hall; J S Stephenson; M J Jones; W S Ngu; M A Horsfield; A Rajesh; A R Dennison; G Garcea Journal: J Gastrointest Surg Date: 2015-10-06 Impact factor: 3.452
Authors: Ari Leppäniemi; Matti Tolonen; Antonio Tarasconi; Helmut Segovia-Lohse; Emiliano Gamberini; Andrew W Kirkpatrick; Chad G Ball; Neil Parry; Massimo Sartelli; Daan Wolbrink; Harry van Goor; Gianluca Baiocchi; Luca Ansaloni; Walter Biffl; Federico Coccolini; Salomone Di Saverio; Yoram Kluger; Ernest Moore; Fausto Catena Journal: World J Emerg Surg Date: 2019-06-13 Impact factor: 5.469