Literature DB >> 21576440

Penetration of ertapenem into muscle measured by in vivo microdialysis in mechanically ventilated patients.

I Boyadjiev1, A Boulamery, N Simon, C Martin, B Bruguerolle, M Leone.   

Abstract

Ertapenem at 1 g once daily has been suggested to be underdosed in intensive care unit (ICU) patients to attain optimal concentrations in target tissues. Therefore, our study aimed to assess the kinetics of ertapenem in plasma and skeletal muscle in ICU patients using microdialysis. Average muscle free-ertapenem concentrations were above the MIC values of targeted pathogens. In a few patients, the concentrations were below the MIC values. The clinical efficiency of ertapenem at 1 g once daily should be evaluated in a large population of ICU patients.

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Year:  2011        PMID： 21576440      PMCID： PMC3122455          DOI： 10.1128/AAC.00180-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

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