Literature DB >> 21576427

Valacyclovir for herpes simplex encephalitis.

Thomas Pouplin1, Julie Nguyen Pouplin, Pham Van Toi, Niklas Lindegardh, H Rogier van Doorn, Tran Tinh Hien, Jeremy Farrar, M Estée Török, Tran Thi Hong Chau.   

Abstract

The recommended treatment for herpes simplex encephalitis (HSE) remains intravenous acyclovir. In resource-poor countries, however, intravenous formulations are usually unavailable or unaffordable. We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected HSE in resource-limited settings.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21576427      PMCID： PMC3122427          DOI： 10.1128/AAC.01023-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

1.  Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-2003. A 50-year-old Colombian man with fever and seizures.

Authors:  Clyde S Crumpacker; R Gilberto Gonzalez; Robert S Makar
Journal:  N Engl J Med       Date:  2003-08-21       Impact factor: 91.245

2.  Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanine in serum and urine using solid-phase extraction and high-performance liquid chromatography.

Authors:  J O Svensson; L Barkholt; J Säwe
Journal:  J Chromatogr B Biomed Sci Appl       Date:  1997-03-07

Review 3.  The spectrum of antiviral activities of acyclovir in vitro and in vivo.

Authors:  P Collins
Journal:  J Antimicrob Chemother       Date:  1983-09       Impact factor: 5.790

4.  Vidarabine versus acyclovir therapy in herpes simplex encephalitis.

Authors:  R J Whitley; C A Alford; M S Hirsch; R T Schooley; J P Luby; F Y Aoki; D Hanley; A J Nahmias; S J Soong
Journal:  N Engl J Med       Date:  1986-01-16       Impact factor: 91.245

5.  Pharmacokinetics of the acyclovir pro-drug valaciclovir after escalating single- and multiple-dose administration to normal volunteers.

Authors:  S Weller; M R Blum; M Doucette; T Burnette; D M Cederberg; P de Miranda; M L Smiley
Journal:  Clin Pharmacol Ther       Date:  1993-12       Impact factor: 6.875

6.  Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients.

Authors:  B Sköldenberg; M Forsgren; K Alestig; T Bergström; L Burman; E Dahlqvist; A Forkman; A Frydén; K Lövgren; K Norlin
Journal:  Lancet       Date:  1984-09-29       Impact factor: 79.321

7.  Acyclovir levels in serum and cerebrospinal fluid after oral administration of valacyclovir.

Authors:  Jan Lycke; Clas Malmeström; Lars Ståhle
Journal:  Antimicrob Agents Chemother       Date:  2003-08       Impact factor: 5.191

8.  Pharmacokinetics of acyclovir in humans following intravenous administration. A model for the development of parenteral antivirals.

Authors:  R J Whitley; M R Blum; N Barton; P de Miranda
Journal:  Am J Med       Date:  1982-07-20       Impact factor: 4.965

9.  Absolute bioavailability and metabolic disposition of valaciclovir, the L-valyl ester of acyclovir, following oral administration to humans.

Authors:  J Soul-Lawton; E Seaber; N On; R Wootton; P Rolan; J Posner
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

10.  Viral etiology of encephalitis in children in southern Vietnam: results of a one-year prospective descriptive study.

Authors:  Van Tan Le; Tu Qui Phan; Quang Ha Do; Bach Hue Nguyen; Quoi Bao Lam; Van Cam Bach; Huu Khanh Truong; Tinh Hien Tran; Van Vinh Chau Nguyen; Tan Tram Tran; Minh Hien Vo; Vu Thieu Nga Tran; Constance Schultsz; Jeremy Farrar; H Rogier van Doorn; Menno D de Jong
Journal:  PLoS Negl Trop Dis       Date:  2010-10-26
View more
  20 in total

1.  Herpes simplex and varicella zoster CNS infections: clinical presentations, treatments and outcomes.

Authors:  Quanhathai Kaewpoowat; Lucrecia Salazar; Elizabeth Aguilera; Susan H Wootton; Rodrigo Hasbun
Journal:  Infection       Date:  2015-12-17       Impact factor: 3.553

Review 2.  Herpes Simplex Encephalitis: an Update.

Authors:  John W Gnann; Richard J Whitley
Journal:  Curr Infect Dis Rep       Date:  2017-03       Impact factor: 3.725

Review 3.  Acute viral infections of the central nervous system in immunocompetent adults: diagnosis and management.

Authors:  Marie Studahl; Lars Lindquist; Britt-Marie Eriksson; Göran Günther; Malin Bengner; Elisabeth Franzen-Röhl; Jan Fohlman; Tomas Bergström; Elisabeth Aurelius
Journal:  Drugs       Date:  2013-02       Impact factor: 9.546

Review 4.  Viral Hypothesis and Antiviral Treatment in Alzheimer's Disease.

Authors:  D P Devanand
Journal:  Curr Neurol Neurosci Rep       Date:  2018-07-14       Impact factor: 5.081

5.  Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1.

Authors:  Matthew A Wozniak; Alison L Frost; Chris M Preston; Ruth F Itzhaki
Journal:  PLoS One       Date:  2011-10-07       Impact factor: 3.240

Review 6.  Fluid Stewardship of Maintenance Intravenous Fluids.

Authors:  John R Carr; W Anthony Hawkins; Andrea Sikora Newsome; Susan E Smith; Clemmons Amber B; Christopher M Bland; Trisha N Branan
Journal:  J Pharm Pract       Date:  2021-04-08

7.  CNS infections in patients with hematological disorders (including allogeneic stem-cell transplantation)-Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).

Authors:  M Schmidt-Hieber; G Silling; E Schalk; W Heinz; J Panse; O Penack; M Christopeit; D Buchheidt; U Meyding-Lamadé; S Hähnel; H H Wolf; M Ruhnke; S Schwartz; G Maschmeyer
Journal:  Ann Oncol       Date:  2016-04-06       Impact factor: 32.976

8.  Population pharmacokinetics of intravenous acyclovir in preterm and term infants.

Authors:  Mario R Sampson; Barry T Bloom; Robert W Lenfestey; Barrie Harper; Angela D Kashuba; Ravinder Anand; Daniel K Benjamin; Edmund Capparelli; Michael Cohen-Wolkowiez; P Brian Smith
Journal:  Pediatr Infect Dis J       Date:  2014-01       Impact factor: 3.806

9.  Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years.

Authors:  Le Van Tan; Le Hong Thai; Nguyen Hoan Phu; Ho Dang Trung Nghia; Ly Van Chuong; Dinh Xuan Sinh; Nguyen Duy Phong; Nguyen Thi Hoang Mai; Dinh Nguyen Huy Man; Vo Minh Hien; Nguyen Thanh Vinh; Jeremy Day; Nguyen Van Vinh Chau; Tran Tinh Hien; Jeremy Farrar; Menno D de Jong; Guy Thwaites; H Rogier van Doorn; Tran Thi Hong Chau
Journal:  PLoS Negl Trop Dis       Date:  2014-08-28

Review 10.  Herpes Simplex Virus Type 1 and Other Pathogens are Key Causative Factors in Sporadic Alzheimer's Disease.

Authors:  Steven A Harris; Elizabeth A Harris
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.