| Literature DB >> 2157601 |
R M Quock1, J A Best, D C Chen, L K Vaughn, P S Portoghese, A E Takemori.
Abstract
Exposure to nitrous oxide produced concentration-dependent analgesia in the mouse abdominal constriction test. Intracerebroventricular or intrathecal pretreatment with naltrexone or nor-binaltorphimine significantly reduced nitrous oxide analgesia. However, similar pretreatment with beta-funaltrexamine had no appreciable effect. These findings suggest that nitrous oxide analgesia involves spinal and supraspinal kappa-opioid receptors.Entities:
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Year: 1990 PMID: 2157601 DOI: 10.1016/0014-2999(90)90158-3
Source DB: PubMed Journal: Eur J Pharmacol ISSN: 0014-2999 Impact factor: 4.432