BACKGROUND: The association between smoking and tuberculosis (TB) treatment failure has not yet been assessed in Morocco. OBJECTIVE: To evaluate the impact of smoking on the failure rate of patients with TB. METHODS: A cohort of 727 new TB cases was followed between 2004 and 2009. Socio-demographic measurements and smoking status were collected by questionnaire. Treatment failure was defined according to international guidelines. Univariate analyses were used to assess associations of treatment failure with smoking status and demographic characteristics. Multivariate logistic regression was used to adjust for potential confounding. RESULTS: The patients' mean age was 35.0 ± 13.2 years. The monthly household income was <€180 for 71.4% of the patients. The rate of treatment failure was 6.9%. Failure was significantly higher among smokers (9.1% vs. 4.5%; P < 0.01), alcohol drinkers (18.5% vs. 4.9%; P < 0.01), and those with a monthly income of <€180 (8.4% vs. 3.3%; P < 0.01). After adjusting for confounding variables, smoking and low income remained significantly associated with treatment failure (adjusted OR 2.25, 95%CI 1.06-4.76, and 3.23, 95%CI 1.12-9.32). CONCLUSION: Smoking is associated with TB treatment failure in Morocco. Anti-smoking interventions should be incorporated into current TB case management.
BACKGROUND: The association between smoking and tuberculosis (TB) treatment failure has not yet been assessed in Morocco. OBJECTIVE: To evaluate the impact of smoking on the failure rate of patients with TB. METHODS: A cohort of 727 new TB cases was followed between 2004 and 2009. Socio-demographic measurements and smoking status were collected by questionnaire. Treatment failure was defined according to international guidelines. Univariate analyses were used to assess associations of treatment failure with smoking status and demographic characteristics. Multivariate logistic regression was used to adjust for potential confounding. RESULTS: The patients' mean age was 35.0 ± 13.2 years. The monthly household income was <€180 for 71.4% of the patients. The rate of treatment failure was 6.9%. Failure was significantly higher among smokers (9.1% vs. 4.5%; P < 0.01), alcohol drinkers (18.5% vs. 4.9%; P < 0.01), and those with a monthly income of <€180 (8.4% vs. 3.3%; P < 0.01). After adjusting for confounding variables, smoking and low income remained significantly associated with treatment failure (adjusted OR 2.25, 95%CI 1.06-4.76, and 3.23, 95%CI 1.12-9.32). CONCLUSION: Smoking is associated with TB treatment failure in Morocco. Anti-smoking interventions should be incorporated into current TB case management.
Authors: Jason Chien; John H Hwang; Sedtavut Nilaad; Jorge A Masso-Silva; Sae Jeong Ahn; Elisa K McEachern; Alexander Moshensky; Min-Kwang Byun; Laura E Crotty Alexander Journal: Infect Immun Date: 2020-10-19 Impact factor: 3.441
Authors: E Hayes-Larson; Y Hirsch-Moverman; S Saito; K Frederix; B Pitt; L Maama-Maime; A A Howard Journal: Int J Tuberc Lung Dis Date: 2017-11-01 Impact factor: 2.373
Authors: Bayode Romeo Adegbite; Jean Ronald Edoa; Pacome Achimi Agbo; Jean Claude Dejon-Agobé; Paulin N Essone; Fabrice Lotola-Mougeni; Mirabeau Mbong Ngwese; Arnault Mfoumbi; Chester Mevyann; Micheska Epola; Jeannot Frejus Zinsou; Yabo Josiane Honkpehedji; Selidji Todagbe Agnandji; Peter Gottfried Kremsner; Abraham Sunday Alabi; Ayola Akim Adegnika; Martin Peter Grobusch Journal: Am J Trop Med Hyg Date: 2020-09-17 Impact factor: 3.707
Authors: Medea Gegia; Matthew J Magee; Russell R Kempker; Iagor Kalandadze; Tsira Chakhaia; Jonathan E Golub; Henry M Blumberg Journal: Bull World Health Organ Date: 2015-03-30 Impact factor: 9.408