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Literature DB >> 2157529

Chronic stress-induced changes in locus coeruleus neuronal activity.

L A Pavcovich¹, L M Cancela, M Volosin, V A Molina, O A Ramirez.

Abstract

Locus coeruleus (LC) activity was assessed in rats exposed to either acute or chronic stress. After one immobilization session, the number of spontaneously active LC neurons dramatically decreased. On the other hand, repeated restraint sessions enhanced noradrenergic (NA) transmission and the inhibitory effect of clonidine (CLON) was greater on these cells than in those of controls. These results bear on the adaptive changes in the NA system following acute or chronic stress.

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Year: 1990 PMID： 2157529 DOI： 10.1016/0361-9230(90)90219-p

Source DB: PubMed Journal: Brain Res Bull ISSN： 0361-9230 Impact factor: 4.077

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Cited

9 in total

1. Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling.

Authors: M J Skelly; A E Chappell; E Carter; J L Weiner
Journal: Neuropharmacology Date: 2015-06-01 Impact factor: 5.250

2. Altered Expression of Phox2 Transcription Factors in the Locus Coeruleus in Major Depressive Disorder Mimicked by Chronic Stress and Corticosterone Treatment In Vivo and In Vitro.

Authors: Yan Fan; Ping Chen; Muhammad U Raza; Attila Szebeni; Katalin Szebeni; Gregory A Ordway; Craig A Stockmeier; Meng-Yang Zhu
Journal: Neuroscience Date: 2018-10-11 Impact factor: 3.590

8. Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons.

Authors: Hank P Jedema; Stephen J Gold; Guillermo Gonzalez-Burgos; Alan F Sved; Ben J Tobe; Theodore Wensel; Anthony A Grace
Journal: Eur J Neurosci Date: 2008-05 Impact factor: 3.386

9. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.

Authors: Mary J Skelly; Jeff L Weiner
Journal: Brain Behav Date: 2014-04-14 Impact factor: 2.708

9 in total

Chronic stress-induced changes in locus coeruleus neuronal activity.

1. Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling.

2. Altered Expression of Phox2 Transcription Factors in the Locus Coeruleus in Major Depressive Disorder Mimicked by Chronic Stress and Corticosterone Treatment In Vivo and In Vitro.

3. Involvement of corticotropin-releasing factor in chronic stress regulation of the brain noradrenergic system.

4. Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression.

Review 5. Regulation of monoamine transporters: influence of psychostimulants and therapeutic antidepressants.

6. Previous stress increases in vivo biogenic amine response to swim stress.

7. Desipramine potentiation of the acute depressant effects of ethanol: modulation by alpha2-adrenoreceptors and stress.

8. Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons.

9. Chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.