Literature DB >> 2157524

D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes.

G B Watson1, M A Bolanowski, M P Baganoff, C L Deppeler, T H Lanthorn.   

Abstract

In the Xenopus oocyte preparation, D-cycloserine (DCS) had the profile of a partial agonist at the glycine modulatory site of the NMDA receptor. Maximal NMDA responses in the presence of DCS were only 40-50% of those in the presence of glycine. Glycine and D-serine were agonists at this site. The actions of DCS were competitively antagonized by HA-966, a known glycine antagonist.

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Year:  1990        PMID： 2157524     DOI： 10.1016/0006-8993(90)90745-w

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  48 in total

1.  A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke.

Authors:  Jasbeer Dhawan; Helene Benveniste; Zhongchi Luo; Marta Nawrocky; S David Smith; Anat Biegon
Journal:  Future Neurol       Date:  2011-11-01

Review 2.  Molecular aspects of glutamate dysregulation: implications for schizophrenia and its treatment.

Authors:  Christine Konradi; Stephan Heckers
Journal:  Pharmacol Ther       Date:  2003-02       Impact factor: 12.310

3.  Treatment of Alzheimer's disease.

Authors:  D M Bowen; P T Francis; A W Procter; A B Young
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-04       Impact factor: 10.154

4.  Anticataleptic potencies of glutamate-antagonists.

Authors:  W J Schmidt; B Zadow; B D Kretschmer; W Hauber
Journal:  Amino Acids       Date:  1991-06       Impact factor: 3.520

Review 5.  Glutamatergic regulation of cognition and functional brain connectivity: insights from pharmacological, genetic and translational schizophrenia research.

Authors:  Maria R Dauvermann; Graham Lee; Neil Dawson
Journal:  Br J Pharmacol       Date:  2017-08-11       Impact factor: 8.739

Review 6.  D-cycloserine: an evolving role in learning and neuroplasticity in schizophrenia.

Authors:  Donald C Goff
Journal:  Schizophr Bull       Date:  2012-02-23       Impact factor: 9.306

Review 7.  Glutamate: its role in learning, memory, and the aging brain.

Authors:  W J McEntee; T H Crook
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

8.  A glycinergic intervention potentiates the antiseizure efficacies of MK-801, flurazepam, and carbamazepine.

Authors:  D O Norris; J Mastropaolo; D A O'Connor; J M Cohen; S I Deutsch
Journal:  Neurochem Res       Date:  1994-02       Impact factor: 3.996

9.  Gene expression patterns in hypoxic and post-hypoxic adult rat retina with special reference to the NMDA receptor and its interactome.

Authors:  Lori Ann Crosson; Roger A Kroes; Joseph R Moskal; Robert A Linsenmeier
Journal:  Mol Vis       Date:  2009-02-09       Impact factor: 2.367

10.  Glutamatergic Synaptic Dysfunction and Obsessive-Compulsive Disorder.

Authors:  Jonathan T Ting; Guoping Feng
Journal:  Curr Chem Genomics       Date:  2008-01-01
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