OBJECTIVE: We have investigated the effects of active and passive smoking on renal functions in terms of glomerular filtration rate, microalbuminuria, and β-2 microglobulin excretion. DESIGN AND METHOD: The volunteers included in this study were classified into three groups as active smokers (n = 24), passive smokers (n = 20), and controls (n = 20). Blood and urine samples were collected from all groups. Serum glucose, urea, creatinine, and cotinine levels in the collected blood samples were measured. Also, microalbumin, β-2 microglobulin, and creatinine levels were measured in the collected urine samples. RESULTS: Serum cotinine levels were found to be higher in both passive and active smokers when compared with controls ( p < 0.01), whereas urinary microalbumin and creatinine levels were significantly higher in active smokers ( p < 0.01). The urinary microalbumin/creatinine ratio was significantly increased in both active and passive smokers compared with controls. CONCLUSION: The kidney and the glomerular functions may be affected even by passive smoking. In addition, increased microalbumin/creatinine ratio may be a sign of increased atherosclerosis risk in these persons.
OBJECTIVE: We have investigated the effects of active and passive smoking on renal functions in terms of glomerular filtration rate, microalbuminuria, and β-2 microglobulin excretion. DESIGN AND METHOD: The volunteers included in this study were classified into three groups as active smokers (n = 24), passive smokers (n = 20), and controls (n = 20). Blood and urine samples were collected from all groups. Serum glucose, urea, creatinine, and cotinine levels in the collected blood samples were measured. Also, microalbumin, β-2 microglobulin, and creatinine levels were measured in the collected urine samples. RESULTS: Serum cotinine levels were found to be higher in both passive and active smokers when compared with controls ( p < 0.01), whereas urinary microalbumin and creatinine levels were significantly higher in active smokers ( p < 0.01). The urinary microalbumin/creatinine ratio was significantly increased in both active and passive smokers compared with controls. CONCLUSION: The kidney and the glomerular functions may be affected even by passive smoking. In addition, increased microalbumin/creatinine ratio may be a sign of increased atherosclerosis risk in these persons.
Authors: Carlos Alberto de Moraes; Bárbara Valtudes Nogueira Thal; Julia Veronese Bannwart; Regiane Aparecida Jacomini; Mercia Breda-Stella; Cesar Alexandre Fabrega Carvalho Journal: Einstein (Sao Paulo) Date: 2022-07-25