Literature DB >> 2157471

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB.

M Sheng1, G McFadden, M E Greenberg.   

Abstract

The mechanism by which the calcium influx signal, triggered by membrane depolarization, is transduced to the nucleus to activate c-fos proto-oncogene transcription has been characterized. A calcium response element (CaRE) that is indistinguishable from a cAMP response element (CRE) mediates transcriptional inducibility by depolarization. Its cognate transcription factor CREB is the target for both calcium and cAMP signals. CREB is rapidly phosphorylated in response to depolarization or cAMP, at a site known to be important for the transcriptional activating function of this protein. The convergent effects of calcium and cAMP on CREB activation are mediated by distinct protein kinase signaling pathways. CREB and its binding site, the Ca/CRE, can thus function as a regulatory element that integrates both calcium and cAMP signals in the control of gene expression.

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Year:  1990        PMID： 2157471     DOI： 10.1016/0896-6273(90)90115-v

Source DB:  PubMed          Journal:  Neuron        ISSN： 0896-6273            Impact factor:   17.173


  242 in total

1.  Molecular determinant for run-down of L-type Ca2+ channels localized in the carboxyl terminus of the 1C subunit.

Authors:  K J Kepplinger; G Förstner; H Kahr; K Leitner; P Pammer; K Groschner; N M Soldatov; C Romanin
Journal:  J Physiol       Date:  2000-11-15       Impact factor: 5.182

2.  Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal.

Authors:  Dan Georgescu; Venetia Zachariou; Michel Barrot; Michihiro Mieda; Jon T Willie; Amelia J Eisch; Masashi Yanagisawa; Eric J Nestler; Ralph J DiLeone
Journal:  J Neurosci       Date:  2003-04-15       Impact factor: 6.167

3.  AMPA receptor-mediated, calcium-dependent CREB phosphorylation in a subpopulation of auditory neurons surviving activity deprivation.

Authors:  L Zirpel; M A Janowiak; C A Veltri; T N Parks
Journal:  J Neurosci       Date:  2000-08-15       Impact factor: 6.167

4.  15N-labeled brain enables quantification of proteome and phosphoproteome in cultured primary neurons.

Authors:  Lujian Liao; Richard C Sando; John B Farnum; Peter W Vanderklish; Anton Maximov; John R Yates
Journal:  J Proteome Res       Date:  2011-12-02       Impact factor: 4.466

5.  Effects of A-CREB, a dominant negative inhibitor of CREB, on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo.

Authors:  Daniel Lubelski; Todd A Ponzio; Harold Gainer
Journal:  Brain Res       Date:  2011-10-26       Impact factor: 3.252

6.  Magnitude of the CREB-dependent transcriptional response is determined by the strength of the interaction between the kinase-inducible domain of CREB and the KIX domain of CREB-binding protein.

Authors:  A J Shaywitz; S L Dove; J M Kornhauser; A Hochschild; M E Greenberg
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

7.  Glutamate, but not dopamine, stimulates stress-activated protein kinase and AP-1-mediated transcription in striatal neurons.

Authors:  M A Schwarzschild; R L Cole; S E Hyman
Journal:  J Neurosci       Date:  1997-05-15       Impact factor: 6.167

8.  Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB.

Authors:  Elke Oetjen; Daniela Grapentin; Roland Blume; Michael Seeger; Doris Krause; Anke Eggers; Willhart Knepel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-02-20       Impact factor: 3.000

9.  Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells.

Authors:  J K Yoon; L F Lau
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Type I adenylyl cyclase functions as a coincidence detector for control of cyclic AMP response element-mediated transcription: synergistic regulation of transcription by Ca2+ and isoproterenol.

Authors:  S Impey; G Wayman; Z Wu; D R Storm
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272
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