Literature DB >> 2157429

IL1 induces proliferation and IL6 mRNA expression in a human astrocytoma cell line: positive and negative modulation by chorela toxin and cAMP.

T Kasahara1, H Yagisawa, K Yamashita, Y Yamaguchi, Y Akiyama.   

Abstract

A human astrocytoma cell line, U373, and its subclones showed a high proliferative response to IL1 alpha or IL1 beta with concomitant IL6 production and IL6 mRNA accumulation. IL1 itself raised neither the cAMP level nor the intracellular Ca2+ level nor did it induce phosphatidylinositol (PI) breakdown. Chorela toxin (CT) and pertussis toxin (PT)-pretreatment markedly inhibited IL1-induced proliferation, while CT enhanced IL1-induced IL6 mRNA expression significantly. Drugs raising cellular cAMP level or cAMP analogues augmented IL1-mediated IL6 mRNA expression but much less. Although cAMP is not directly involved in the IL1 action, cAMP thus has a modulatory effect on IL1-mediated IL6 gene activation.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2157429     DOI： 10.1016/0006-291x(90)90657-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  15 in total

1.  Evidence that responses of articular chondrocytes to interleukin-1 and basic fibroblast growth factor are not mediated by protein kinase C.

Authors:  K I Hulkower; H I Georgescu; C H Evans
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

2.  Astrocyte elevated gene-1 is a novel modulator of HIV-1-associated neuroinflammation via regulation of nuclear factor-κB signaling and excitatory amino acid transporter-2 repression.

Authors:  Neha Vartak-Sharma; Benjamin B Gelman; Chaitanya Joshi; Kathleen Borgamann; Anuja Ghorpade
Journal:  J Biol Chem       Date:  2014-05-22       Impact factor: 5.157

Review 3.  Physiological and pathological roles of interleukin-6 in the central nervous system.

Authors:  D L Gruol; T E Nelson
Journal:  Mol Neurobiol       Date:  1997-12       Impact factor: 5.590

4.  Characteristics of the Ca(2+)-dependent inhibition of cyclic AMP accumulation by histamine and thapsigargin in human U373 MG astrocytoma cells.

Authors:  M P Wong; D M Cooper; K W Young; J M Young
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

5.  Amyloid beta peptide potentiates cytokine secretion by interleukin-1 beta-activated human astrocytoma cells.

Authors:  B D Gitter; L M Cox; R E Rydel; P C May
Journal:  Proc Natl Acad Sci U S A       Date:  1995-11-07       Impact factor: 11.205

6.  Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: mode of action and augmenting effect of inflammatory cytokines.

Authors:  D W McGee; C O Elson; J R McGhee
Journal:  Infect Immun       Date:  1993-11       Impact factor: 3.441

7.  A nitric oxide/Ca(2+)/calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1beta in human astrocytoma cells.

Authors:  A Meini; C Sticozzi; L Massai; M Palmi
Journal:  Br J Pharmacol       Date:  2008-02-25       Impact factor: 8.739

8.  IL-1 and TNF-alpha induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line.

Authors:  T Kasahara; N Mukaida; K Yamashita; H Yagisawa; T Akahoshi; K Matsushima
Journal:  Immunology       Date:  1991-09       Impact factor: 7.397

9.  Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor alpha and interleukin-6 by increasing intracellular cyclic AMP.

Authors:  D L Hoover; A M Friedlander; L C Rogers; I K Yoon; R L Warren; A S Cross
Journal:  Infect Immun       Date:  1994-10       Impact factor: 3.441

Review 10.  Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology.

Authors:  Martha L Slattery; F A Fitzpatrick
Journal:  Cancer Prev Res (Phila)       Date:  2009-11
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.