Literature DB >> 2157425

Genomic DNA 5' to the mouse and human angiotensin-converting enzyme genes contains two distinct regions of conserved sequence.

S Y Shai1, K G Langford, B M Martin, K E Bernstein.   

Abstract

Genomic DNA 5' to the mouse and human genes encoding angiotensin-converting enzyme has been isolated and analyzed. A sequence comparison identifies two discrete regions of genomic DNA that are highly conserved. One region, found immediately 5' to the mouse and human ACE genes, is a GC rich segment that contains a "TATA box" and several potential Spl binding sites. The second conserved region is found further 5' and contains several potential regulatory cis elements including a possible glucocorticoid responsive element. These two regions of genomic DNA may influence the rate of mRNA transcription from the angiotensin-converting enzyme gene.

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Year:  1990        PMID： 2157425     DOI： 10.1016/0006-291x(90)90640-9

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  14 in total

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2.  New nucleotide sequence data on the EMBL File Server.

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Journal:  Nucleic Acids Res       Date:  1990-09-11       Impact factor: 16.971

3.  Analysis of the negative transcriptional regulatory element in the angiotensin-converting enzyme gene.

Authors:  S P Kessler; T Y Goraya; G C Sen
Journal:  Gene Expr       Date:  1996

4.  Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men.

Authors:  A Bukowska; L Spiller; C Wolke; U Lendeckel; S Weinert; J Hoffmann; P Bornfleth; I Kutschka; A Gardemann; B Isermann; A Goette
Journal:  Exp Biol Med (Maywood)       Date:  2017-06-29

5.  Identification of positive and negative transcriptional regulatory elements of the rabbit angiotensin-converting enzyme gene.

Authors:  T Y Goraya; S P Kessler; R S Kumar; J Douglas; G C Sen
Journal:  Nucleic Acids Res       Date:  1994-04-11       Impact factor: 16.971

Review 6.  Diverse factors influencing angiotensin metabolism during ACE inhibition: insights from molecular biology and genetic studies.

Authors:  K Morgan
Journal:  Br Heart J       Date:  1994-09

7.  20-HETE Activates the Transcription of Angiotensin-Converting Enzyme via Nuclear Factor-κB Translocation and Promoter Binding.

Authors:  Victor Garcia; Brian Shkolnik; Laura Milhau; John R Falck; Michal Laniado Schwartzman
Journal:  J Pharmacol Exp Ther       Date:  2015-12-23       Impact factor: 4.030

8.  Role of cortisol in the ontogenic control of pulmonary and renal angiotensin-converting enzyme in fetal sheep near term.

Authors:  A J Forhead; C E Gillespie; A L Fowden
Journal:  J Physiol       Date:  2000-07-15       Impact factor: 5.182

9.  Functional analysis of the human somatic angiotensin I-converting enzyme gene promoter.

Authors:  P Testut; F Soubrier; P Corvol; C Hubert
Journal:  Biochem J       Date:  1993-08-01       Impact factor: 3.857

10.  Sperm-specific expression of angiotensin-converting enzyme (ACE) is mediated by a 91-base-pair promoter containing a CRE-like element.

Authors:  T Howard; R Balogh; P Overbeek; K E Bernstein
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272
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