Literature DB >> 2157421

Drug targeting: anti-HSV-1 activity of mannosylated polymer-bound 9-(2-phosphonylmethoxyethyl)adenine.

P Midoux1, E Negre, A C Roche, R Mayer, M Monsigny, J Balzarini, E De Clercq, E Mayer, A Ghaffar, J D Gangemi.   

Abstract

The antiviral drug, 9-(2-phosphonylmethoxyethyl) adenine (PMEA) was linked to a synthetic and neutral polymer bearing mannosyl residues to allow its internalization by macrophages via membrane lectins. PMEA bound to the mannosylated polymer was more efficient in vitro than free PMEA in preventing lysis of human macrophages by herpes virus.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2157421     DOI： 10.1016/0006-291x(90)90628-z

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  2 in total

1.  Antileishmanial drug targeting through glycosylated polymers specifically internalized by macrophage membrane lectins.

Authors:  E Nègre; M L Chance; S Y Hanboula; M Monsigny; A C Roche; R M Mayer; M Hommel
Journal:  Antimicrob Agents Chemother       Date:  1992-10       Impact factor: 5.191

2.  Drug targeting: synthesis and endocytosis of oligonucleotide-neoglycoprotein conjugates.

Authors:  E Bonfils; C Depierreux; P Midoux; N T Thuong; M Monsigny; A C Roche
Journal:  Nucleic Acids Res       Date:  1992-09-11       Impact factor: 16.971
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.