Literature DB >> 2157419

Lipoxin A4 inhibits phosphoinositide hydrolysis in human neutrophils.

B M Grandordy1, H Lacroix, E Mavoungou, S Krilis, A E Crea, B W Spur, T H Lee.   

Abstract

Lipoxins (LX) are trihydroxytetraene metabolites derived from arachidonic acid via an interaction between the 5- and 15-lipoxygenases. Preincubation of [3H] myo-inositol labeled PMN with 10-7M and 10-5M LXA4 for 1 minute at 37 degrees C resulted in a concentration dependent inhibition of the generation of [3H] IP3 and [3H] IP in cells subsequently stimulated by increasing doses of LTB4 or FMLP for 1 minute at 37 degrees C. Preincubation of PMN with LXA4 did not inhibit specific binding of [3H] LTB4 to PMN. These results indicate that LXA4 inhibits chemotactic factor-induced phosphoinositide hydrolysis at a post-receptor level.

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Year:  1990        PMID： 2157419     DOI： 10.1016/0006-291x(90)90625-w

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  9 in total

1.  Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs.

Authors:  A T Gewirtz; B McCormick; A S Neish; N A Petasis; K Gronert; C N Serhan; J L Madara
Journal:  J Clin Invest       Date:  1998-05-01       Impact factor: 14.808

2.  Stimulation of protein kinase C redistribution and inhibition of leukotriene B4-induced inositol 1,4,5-trisphosphate generation in human neutrophils by lipoxin A4.

Authors:  K O Chung-a-on; O Soyombo; B W Spur; T H Lee
Journal:  Br J Pharmacol       Date:  1996-03       Impact factor: 8.739

Review 3.  Lipoxin A4: a novel anti-inflammatory molecule?

Authors:  T H Lee
Journal:  Thorax       Date:  1995-02       Impact factor: 9.139

4.  Role of arachidonic acid and its metabolites in the priming of NADPH oxidase in human polymorphonuclear leukocytes by peritoneal dialysis effluent.

Authors:  I Daniels; M A Lindsay; C I Keany; R P Burden; J Fletcher; A P Haynes
Journal:  Clin Diagn Lab Immunol       Date:  1998-09

5.  Lipoxin A4 modulates transmigration of human neutrophils across intestinal epithelial monolayers.

Authors:  S P Colgan; C N Serhan; C A Parkos; C Delp-Archer; J L Madara
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

6.  Transmembrane signaling in human polymorphonuclear neutrophils: 15(S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid modulates receptor agonist-triggered cell activation.

Authors:  R J Smith; J M Justen; E G Nidy; L M Sam; J E Bleasdale
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

7.  Remodeling of neutrophil phospholipids with 15(S)-hydroxyeicosatetraenoic acid inhibits leukotriene B4-induced neutrophil migration across endothelium.

Authors:  S Takata; M Matsubara; P G Allen; P A Janmey; C N Serhan; H R Brady
Journal:  J Clin Invest       Date:  1994-02       Impact factor: 14.808

8.  Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors.

Authors:  T Takano; S Fiore; J F Maddox; H R Brady; N A Petasis; C N Serhan
Journal:  J Exp Med       Date:  1997-05-05       Impact factor: 14.307

9.  Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils.

Authors:  S Fiore; C N Serhan
Journal:  J Exp Med       Date:  1990-11-01       Impact factor: 14.307
  9 in total

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