BACKGROUND AND PURPOSE: A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke. MATERIAL AND METHODS: We genotyped 428 controls and 301 CE stroke patients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction. RESULTS: Both univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive mo-dels. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors. CONCLUSIONS: The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.
BACKGROUND AND PURPOSE: A few single nucleotide polymorphisms (SNPs) on chromosome 4q25, associated with atrial fibrillation (AF), are risk factors for ischaemic stroke. We studied the significance of the SNP rs2200733 on chromosome 4q25 in different types of cardioembolic (CE) stroke. MATERIAL AND METHODS: We genotyped 428 controls and 301 CE strokepatients, among whom 197 (65.4%) presented with high risk sources of embolism (CE stroke related to AF) and 104 with medium risk sources (CE stroke unrelated to AF). The SNP rs2200733 was analysed using real-time polymorphism chain reaction. RESULTS: Both univariate and multivariate regression analyses showed that the studied variant affected risk of all CE strokes or CE strokes related to AF in recessive and additive mo-dels. The two types of CE stroke differed significantly in demographics and distribution of vascular risk factors. CONCLUSIONS: The SNP rs2200733 on chromosome 4q25 is a risk factor for CE stroke related to AF only.
Authors: Wei-Qi Wei; Qiping Feng; Peter Weeke; William Bush; Magarya S Waitara; Otito F Iwuchukwu; Dan M Roden; Russell A Wilke; Charles M Stein; Joshua C Denny Journal: AMIA Jt Summits Transl Sci Proc Date: 2014-04-07
Authors: Yuliya Mints; Hirad Yarmohammadi; Irfan M Khurram; Hana Hoyt; Rozann Hansford; Stefan L Zimmerman; Steven J Steinberg; Daniel P Judge; Gordon F Tomaselli; Hugh Calkins; Vadim Zipunnikov; Saman Nazarian Journal: Clin Med Insights Cardiol Date: 2015-05-13