PURPOSE: To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest. METHODS: Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls. RESULTS: The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001). CONCLUSION: The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.
PURPOSE: To investigate the association between the UBR2 gene and the risk of azoospermia caused by meiotic arrest. METHODS: Mutational analysis of the UBR2 gene was performed using DNA from 30 patients with azoospermia by meiotic arrest to 80 normal controls. RESULTS: The genotypic and allelic frequencies of c.1,066A>T variant were significantly higher in patient than control groups (p < 0.001). CONCLUSION: The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.
Authors: Alexander N Yatsenko; Angshumoy Roy; Ruihong Chen; Lang Ma; Lata J Murthy; Wei Yan; Dolores J Lamb; Martin M Matzuk Journal: Hum Mol Genet Date: 2006-10-17 Impact factor: 6.150
Authors: D J Elliott; M R Millar; K Oghene; A Ross; F Kiesewetter; J Pryor; M McIntyre; T B Hargreave; P T Saunders; P H Vogt; A C Chandley; H Cooke Journal: Proc Natl Acad Sci U S A Date: 1997-04-15 Impact factor: 11.205
Authors: R Reijo; T Y Lee; P Salo; R Alagappan; L G Brown; M Rosenberg; S Rozen; T Jaffe; D Straus; O Hovatta Journal: Nat Genet Date: 1995-08 Impact factor: 38.330
Authors: D L Pittman; J Cobb; K J Schimenti; L A Wilson; D M Cooper; E Brignull; M A Handel; J C Schimenti Journal: Mol Cell Date: 1998-04 Impact factor: 17.970
Authors: W Edelmann; P E Cohen; B Kneitz; N Winand; M Lia; J Heyer; R Kolodner; J W Pollard; R Kucherlapati Journal: Nat Genet Date: 1999-01 Impact factor: 38.330
Authors: U Asadpor; M Totonchi; M Sabbaghian; H Hoseinifar; M R Akhound; Sh Zari Moradi; K Haratian; M A Sadighi Gilani; H Gourabi; A Mohseni Meybodi Journal: J Assist Reprod Genet Date: 2013-06-19 Impact factor: 3.412