BACKGROUND: The role of vitamins and mineral supplementation in the prevention of diabetes mellitus is not well elucidated. OBJECTIVE: The effect of prior administration of magnesium on alloxan induced diabetes was assessed in rats. METHODS: 36 Male albino rats were used for this study. The animals were divided into 6 groups of 6 animals each; group 1 was healthy control; groups 2 served as diabetic control. Animals in group 3 received magnesium (100 mg/kg) i.p one hour prior to alloxan (120 mg/kg) administration, group 4 were also received magnesium (150 mg/kg) i.p one hour prior to alloxan administration. Animals in group 5 received magnesium (100 mg/kg) i.p only; group 6 animals received magnesium (150 mg/kg) i.p only. Blood samples were obtained from all animals and plasma glucose levels were determined on Day 0 (prior to treatment), Day 2, Day 5, Day 7 and Day 10 after the commencement of treatment. RESULTS: There was significant increase (P<0.001) in plasma glucose values in the alloxan treated group when compared with the control values. There was also a significant increase (P<0.01) in plasma glucose levels in the magnesium-pretreated (100 mg/kg and 150 mg/kg) diabetic groups when compared with healthy controls whereas there was a significant reduction (P<0.01) in plasma glucose level when compared with the diabetic control. CONCLUSION: This study has shown that magnesium pretreatment may delay the onset and subsequently cause a reduction in hyperglycemia in alloxan induced diabetes. This effect of magnesium may be attributed to its role as a scavenger of highly reactive hydroxyl radicals generated through alloxan reactions, its potentiation of glutathione antioxidant production and its role as a calcium blocker.
BACKGROUND: The role of vitamins and mineral supplementation in the prevention of diabetes mellitus is not well elucidated. OBJECTIVE: The effect of prior administration of magnesium on alloxan induced diabetes was assessed in rats. METHODS: 36 Male albino rats were used for this study. The animals were divided into 6 groups of 6 animals each; group 1 was healthy control; groups 2 served as diabetic control. Animals in group 3 received magnesium (100 mg/kg) i.p one hour prior to alloxan (120 mg/kg) administration, group 4 were also received magnesium (150 mg/kg) i.p one hour prior to alloxan administration. Animals in group 5 received magnesium (100 mg/kg) i.p only; group 6 animals received magnesium (150 mg/kg) i.p only. Blood samples were obtained from all animals and plasma glucose levels were determined on Day 0 (prior to treatment), Day 2, Day 5, Day 7 and Day 10 after the commencement of treatment. RESULTS: There was significant increase (P<0.001) in plasma glucose values in the alloxan treated group when compared with the control values. There was also a significant increase (P<0.01) in plasma glucose levels in the magnesium-pretreated (100 mg/kg and 150 mg/kg) diabetic groups when compared with healthy controls whereas there was a significant reduction (P<0.01) in plasma glucose level when compared with the diabetic control. CONCLUSION: This study has shown that magnesium pretreatment may delay the onset and subsequently cause a reduction in hyperglycemia in alloxan induced diabetes. This effect of magnesium may be attributed to its role as a scavenger of highly reactive hydroxyl radicals generated through alloxan reactions, its potentiation of glutathione antioxidant production and its role as a calcium blocker.
Authors: Alain C Van Elstraete; Philippe Sitbon; Jean-Xavier Mazoit; Marc Conti; Dan Benhamou Journal: Can J Anaesth Date: 2006-12 Impact factor: 5.063
Authors: Olatunde O Odusan; Oluranti Babatope Familoni; Adesina O Odewabi; Akolade O Idowu; Ayodeji S Adekolade Journal: Indian J Endocrinol Metab Date: 2017 May-Jun