OBJECTIVE: To compare the prevalence of cupular and free-floating deposits in the semicircular canals between temporal bones of type 1 diabetes mellitus patients and normal controls. STUDY DESIGN: Case-control histopathologic human temporal bone study. SETTING: Otopathology laboratory in a tertiary academic medical center. SUBJECTS AND METHODS: Twenty-eight temporal bones from 14 patients with type 1 diabetes mellitus and 56 normal temporal bones from 28 age-matched individuals were histopathologically examined. The cupula and lumina of the semicircular canals were examined for evidence of deposits. RESULTS: The prevalence of cupular and free-floating deposits in the lateral and posterior semicircular canals was significantly higher in type 1 diabetes mellitus patients compared with normal temporal bones (lateral, cupular deposits, odds ratio [OR], 5.47; 95% confidence interval [CI], 1.43 to 21.02; free-floating deposits, OR, 8.25; 95% CI, 2.42 to 27.85; posterior, cupular deposits, OR, 41.73; 95% CI, 5.96 to 275.50; free-floating deposits, OR, 7.44; 95% CI, 1.91 to 28.53). The prevalence of these deposits was associated with the duration of disease rather than with aging. CONCLUSION: The findings suggest that type 1 diabetes mellitus is associated with cupular and free-floating deposits in the semicircular canals. The patients with type 1 diabetes mellitus with a longer duration of disease have an increased probability of suffering from benign paroxysmal positional vertigo.
OBJECTIVE: To compare the prevalence of cupular and free-floating deposits in the semicircular canals between temporal bones of type 1 diabetes mellituspatients and normal controls. STUDY DESIGN: Case-control histopathologic human temporal bone study. SETTING: Otopathology laboratory in a tertiary academic medical center. SUBJECTS AND METHODS: Twenty-eight temporal bones from 14 patients with type 1 diabetes mellitus and 56 normal temporal bones from 28 age-matched individuals were histopathologically examined. The cupula and lumina of the semicircular canals were examined for evidence of deposits. RESULTS: The prevalence of cupular and free-floating deposits in the lateral and posterior semicircular canals was significantly higher in type 1 diabetes mellituspatients compared with normal temporal bones (lateral, cupular deposits, odds ratio [OR], 5.47; 95% confidence interval [CI], 1.43 to 21.02; free-floating deposits, OR, 8.25; 95% CI, 2.42 to 27.85; posterior, cupular deposits, OR, 41.73; 95% CI, 5.96 to 275.50; free-floating deposits, OR, 7.44; 95% CI, 1.91 to 28.53). The prevalence of these deposits was associated with the duration of disease rather than with aging. CONCLUSION: The findings suggest that type 1 diabetes mellitus is associated with cupular and free-floating deposits in the semicircular canals. The patients with type 1 diabetes mellitus with a longer duration of disease have an increased probability of suffering from benign paroxysmal positional vertigo.
Authors: Linda J D'Silva; Hinrich Staecker; James Lin; Kevin J Sykes; Milind A Phadnis; Tamara M McMahon; Dan Connolly; Carla H Sabus; Susan L Whitney; Patricia M Kluding Journal: J Vestib Res Date: 2016 Impact factor: 2.435
Authors: Marta Alvarez de Linera-Alperi; Octavio Garaycochea; Diego Calavia; David Terrasa; Nicolas Pérez-Fernández; Raquel Manrique-Huarte Journal: Audiol Res Date: 2022-06-19