OBJECTIVE: We investigated differences in task induced responses in occipital and sensorimotor cortex between patients with juvenile myclonic epilepsy (JME) and healthy controls . METHODS: Twelve patients with JME and 12 age-matched non-epilepsy volunteers performed visual and motor tasks during MEG. We used synthetic aperture magnetometry to localise areas of task-related oscillatory modulations, performed time-frequency analyses on the locations of peak task related power changes and compared power and frequency modulation at these locations between patients and controls. RESULTS: Patients with JME had significantly reduced pre-movement beta event-related desynchronisation in the motor task compared to controls. No significant differences were seen in other motor-related responses, or visual oscillatory responses. CONCLUSIONS: Altered beta event-related desynchronisation may represent network specific dysfunction in JME possibly through GABAergic dysfunction. SIGNIFICANCE: Characterising task specific cortical responses in epilepsy offers the potential to understand the patho-physiological basis of seizures and provide a window on disease and treatment effects.
OBJECTIVE: We investigated differences in task induced responses in occipital and sensorimotor cortex between patients with juvenile myclonic epilepsy (JME) and healthy controls . METHODS: Twelve patients with JME and 12 age-matched non-epilepsy volunteers performed visual and motor tasks during MEG. We used synthetic aperture magnetometry to localise areas of task-related oscillatory modulations, performed time-frequency analyses on the locations of peak task related power changes and compared power and frequency modulation at these locations between patients and controls. RESULTS:Patients with JME had significantly reduced pre-movement beta event-related desynchronisation in the motor task compared to controls. No significant differences were seen in other motor-related responses, or visual oscillatory responses. CONCLUSIONS: Altered beta event-related desynchronisation may represent network specific dysfunction in JME possibly through GABAergic dysfunction. SIGNIFICANCE: Characterising task specific cortical responses in epilepsy offers the potential to understand the patho-physiological basis of seizures and provide a window on disease and treatment effects.
Authors: Loes Koelewijn; Khalid Hamandi; Lisa M Brindley; Matthew J Brookes; Bethany C Routley; Suresh D Muthukumaraswamy; Natalie Williams; Marie A Thomas; Amanda Kirby; Johann Te Water Naudé; Frances Gibbon; Krish D Singh Journal: Hum Brain Mapp Date: 2015-07-14 Impact factor: 5.038
Authors: Anne E Campbell; Petroc Sumner; Krish D Singh; Suresh D Muthukumaraswamy Journal: Neuropsychopharmacology Date: 2014-03-13 Impact factor: 7.853
Authors: Suresh D Muthukumaraswamy; Robin L Carhart-Harris; Rosalyn J Moran; Matthew J Brookes; Tim M Williams; David Errtizoe; Ben Sessa; Andreas Papadopoulos; Mark Bolstridge; Krish D Singh; Amanda Feilding; Karl J Friston; David J Nutt Journal: J Neurosci Date: 2013-09-18 Impact factor: 6.167
Authors: Lorenzo Caciagli; Britta Wandschneider; Maria Centeno; Christian Vollmar; Sjoerd B Vos; Karin Trimmel; Lili Long; Fenglai Xiao; Alexander J Lowe; Meneka K Sidhu; Pamela J Thompson; Gavin P Winston; John S Duncan; Matthias J Koepp Journal: Epilepsia Date: 2020-06-25 Impact factor: 6.740