BACKGROUND: Quality of life (QOL) is becoming increasingly important to measure the effect of interventions on the life of patients with Alzheimer's disease (AD), particularly on the most meaningful issues. However, most of the instruments used to measure QOL have not been validated in the Spanish population. The aim of this study was to determine the psychometric properties of a Spanish version of QoL Scale in patients with AD, carers and health professionals. MATERIAL AND METHODS: On hundred and two patients, their carers and 25 health professionals were recruited from day centres. Patients' QOL was rated by patients, carers and health professionals. The Health Utilities Index, Clinical Insight Rating Scale and Mini Mental State Examination were also administered. RESULTS: The internal and external reliability of QoL-AD were excellent. Criterion validity was indicated by a significant correlation of QoL-AD scores with HUI-3 and QoL-AD global item scores (p<.05). Lack of insight and cognitive impairment did not have an effect on these properties. QoL-AD scores were not significantly different between groups made according sociodemographic characteristics and cognitive impairment (p>.05). The exploratory factor analysis result revealed a three factor solution, which accounted for 61.3% of variance: health factor, functional status factor, and social relationship-environment factor. CONCLUSIONS: QoL-AD Scale has proved to be a valid and reliable instrument to measure QoL of Spanish AD patients with mild-to-moderate cognitive impairment and a wide range of anosognosia. Copyright Â
BACKGROUND: Quality of life (QOL) is becoming increasingly important to measure the effect of interventions on the life of patients with Alzheimer's disease (AD), particularly on the most meaningful issues. However, most of the instruments used to measure QOL have not been validated in the Spanish population. The aim of this study was to determine the psychometric properties of a Spanish version of QoL Scale in patients with AD, carers and health professionals. MATERIAL AND METHODS: On hundred and two patients, their carers and 25 health professionals were recruited from day centres. Patients' QOL was rated by patients, carers and health professionals. The Health Utilities Index, Clinical Insight Rating Scale and Mini Mental State Examination were also administered. RESULTS: The internal and external reliability of QoL-AD were excellent. Criterion validity was indicated by a significant correlation of QoL-AD scores with HUI-3 and QoL-AD global item scores (p<.05). Lack of insight and cognitive impairment did not have an effect on these properties. QoL-AD scores were not significantly different between groups made according sociodemographic characteristics and cognitive impairment (p>.05). The exploratory factor analysis result revealed a three factor solution, which accounted for 61.3% of variance: health factor, functional status factor, and social relationship-environment factor. CONCLUSIONS: QoL-AD Scale has proved to be a valid and reliable instrument to measure QoL of Spanish AD patients with mild-to-moderate cognitive impairment and a wide range of anosognosia. Copyright Â
Authors: Emilia Castro-Monteiro; Maria João Forjaz; Alba Ayala; Carmen Rodriguez-Blazquez; Gloria Fernandez-Mayoralas; Alicia Diaz-Redondo; Pablo Martinez-Martin Journal: Qual Life Res Date: 2014-05-07 Impact factor: 4.147
Authors: Daniel Vasquez; Melissa Sierra Castrillón; Manuela Gomez Vega; Clara Gomez Henck; David Aguillon; Elkin Garcia-Cifuentes; Alberto Jaramillo-Jimenez; Juan Esteban Velez; Lucia Madrigal; Francisco Lopera Journal: Neurol Sci Date: 2021-03-05 Impact factor: 3.307
Authors: Haritz Arrieta; Chloe Rezola-Pardo; Iñaki Echeverria; Miren Iturburu; Susana Maria Gil; Jose Javier Yanguas; Jon Irazusta; Ana Rodriguez-Larrad Journal: BMC Geriatr Date: 2018-03-27 Impact factor: 3.921