Jason L Vassy1, Peter Shrader2, Anna Jonsson3, Caroline S Fox4, Valeriya Lyssenko3, Bo Isomaa5, Leif Groop6, James B Meigs7, Paul W Franks8. 1. General Medicine Division, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. 2. General Medicine Division, Massachusetts General Hospital, Boston, MA, USA. 3. Department of Clinical Sciences, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden. 4. Harvard Medical School, Boston, MA, USA; National Heart, Lung, and Blood Institute's Framingham Heart Study and the Center for Population Studies, Framingham, MA, USA. 5. Folkhälsan Research Center, Östanpåvägen 32, 68660 Jakobstad, Finland; Department of Social Services and Health Care, PB 111, 68601 Jakobstad, Finland. 6. Department of Clinical Sciences, Diabetes & Endocrinology Unit, Lund University, Malmö, Sweden; Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland. 7. General Medicine Division, Massachusetts General Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. 8. Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University, Malmö, Sweden; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. Electronic address: Paul.Franks@med.lu.se.
Abstract
OBJECTIVE: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. METHODS: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). RESULTS: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend)=0.03). The trend was similar among Framingham Offspring but was not statistically significant (p=0.07). The meta-analyzed p value for trend from the two studies was 0.005. CONCLUSIONS: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors.
OBJECTIVE: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown. METHODS: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study). RESULTS: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend)=0.03). The trend was similar among Framingham Offspring but was not statistically significant (p=0.07). The meta-analyzed p value for trend from the two studies was 0.005. CONCLUSIONS: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors.
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Authors: J Kaprio; J Tuomilehto; M Koskenvuo; K Romanov; A Reunanen; J Eriksson; J Stengård; Y A Kesäniemi Journal: Diabetologia Date: 1992-11 Impact factor: 10.122
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Authors: R A Scott; C Langenberg; S J Sharp; P W Franks; O Rolandsson; D Drogan; Y T van der Schouw; U Ekelund; N D Kerrison; E Ardanaz; L Arriola; B Balkau; A Barricarte; I Barroso; B Bendinelli; J W J Beulens; H Boeing; B de Lauzon-Guillain; P Deloukas; G Fagherazzi; C Gonzalez; S J Griffin; L C Groop; J Halkjaer; J M Huerta; R Kaaks; K T Khaw; V Krogh; P M Nilsson; T Norat; K Overvad; S Panico; L Rodriguez-Suarez; D Romaguera; I Romieu; C Sacerdote; M J Sánchez; A M W Spijkerman; B Teucher; A Tjonneland; R Tumino; D L van der A; P A Wark; M I McCarthy; E Riboli; N J Wareham Journal: Diabetologia Date: 2012-09-28 Impact factor: 10.122