BACKGROUND AND AIM: There are few reports from Iran about the epidemiology and clinical features of inflammatory bowel disease (IBD). In this study, we aimed to determine the epidemiologic profile and clinical features of ulcerative colitis (UC) in Northwest of Iran. METHODS: This retrospective study covered the time period from 1998 to 2008 and included all patients of a private gasteroenterology clinic in the northwest of Iran, who had diagnosis of UC at the time of presentation or those whose diagnosis had been made later. In addition to description of epidemiology and clinical feature of disease, an attempt was made to identify factors associated with severity of disease. RESULTS: A total of 105 patients including 61 females (58.1%) were evaluated. Mean age of the patients was 33.5 +/- 13.1 years. The median time interval from initiation of symptoms to diagnosis was 9 months. The commonest presentation was proctosigmoiditis. (48.6%). Among extra-intestinal manifestations, sclerosing cholangitis had the highest frequency and was found in 2 (1.9%) patients. Among all evaluated variables, only family income (the higher the income the more severe the disease) and cigarette smoking (inverse association) were find to have significant association with severity of disease. CONCLUSION: A case profile of patients with ulcerative colitis from Northwest Iran suggests that the disease is seen most commonly in the third decade of life with a female preponderance. Family income and smoking influenced the course of ulcerative colitis in Iranian patients.
BACKGROUND AND AIM: There are few reports from Iran about the epidemiology and clinical features of inflammatory bowel disease (IBD). In this study, we aimed to determine the epidemiologic profile and clinical features of ulcerative colitis (UC) in Northwest of Iran. METHODS: This retrospective study covered the time period from 1998 to 2008 and included all patients of a private gasteroenterology clinic in the northwest of Iran, who had diagnosis of UC at the time of presentation or those whose diagnosis had been made later. In addition to description of epidemiology and clinical feature of disease, an attempt was made to identify factors associated with severity of disease. RESULTS: A total of 105 patients including 61 females (58.1%) were evaluated. Mean age of the patients was 33.5 +/- 13.1 years. The median time interval from initiation of symptoms to diagnosis was 9 months. The commonest presentation was proctosigmoiditis. (48.6%). Among extra-intestinal manifestations, sclerosing cholangitis had the highest frequency and was found in 2 (1.9%) patients. Among all evaluated variables, only family income (the higher the income the more severe the disease) and cigarette smoking (inverse association) were find to have significant association with severity of disease. CONCLUSION: A case profile of patients with ulcerative colitis from Northwest Iran suggests that the disease is seen most commonly in the third decade of life with a female preponderance. Family income and smoking influenced the course of ulcerative colitis in Iranian patients.
Authors: Silvio Danese; Rupa Banerjee; Jr Fraser Cummings; Iris Dotan; Paulo G Kotze; Rupert Wing Loong Leong; Kristine Paridaens; Laurent Peyrin-Biroulet; Glyn Scott; Gert Van Assche; Jan Wehkamp; Jesús K Yamamoto-Furusho Journal: Intest Res Date: 2018-10-16