UNLABELLED: The association of celiac disease with type 1 diabetes mellitus is known, but the evolution of celiac disease is most frequently asymptomatic, without any clinical signs. Thus, diagnosis is impossible to make in the absence of serological tests. Our study aimed to determine the prevalence and the efficiency of IgA antitissue transglutaminase antibodies in the screening of celiac disease in children with type 1 diabetes mellitus. METHOD: During the course of 2008-2009, we performed an analytical clinical study that included the determination of IgA antitissue transglutaminase antibodies in a group of 119 children with type 1 diabetes mellitus. Fifty-seven percent of the subjects were male and 43% were female, with a mean age of 11±4 years. RESULTS: By evaluating IgA antitissue transglutaminase antibodies, we obtained a prevalence of 9.2% in children with type 1 diabetes mellitus, with a sensitivity and specificity of 80 and 82.6%, respectively. CONCLUSIONS: There is an increased prevalence of IgA antitissue transglutaminase antibodies, which suggests the need to use this method as an effective first-line test in the screening of celiac disease in children with type 1 diabetes mellitus.
UNLABELLED: The association of celiac disease with type 1 diabetes mellitus is known, but the evolution of celiac disease is most frequently asymptomatic, without any clinical signs. Thus, diagnosis is impossible to make in the absence of serological tests. Our study aimed to determine the prevalence and the efficiency of IgA antitissue transglutaminase antibodies in the screening of celiac disease in children with type 1 diabetes mellitus. METHOD: During the course of 2008-2009, we performed an analytical clinical study that included the determination of IgA antitissue transglutaminase antibodies in a group of 119 children with type 1 diabetes mellitus. Fifty-seven percent of the subjects were male and 43% were female, with a mean age of 11±4 years. RESULTS: By evaluating IgA antitissue transglutaminase antibodies, we obtained a prevalence of 9.2% in children with type 1 diabetes mellitus, with a sensitivity and specificity of 80 and 82.6%, respectively. CONCLUSIONS: There is an increased prevalence of IgA antitissue transglutaminase antibodies, which suggests the need to use this method as an effective first-line test in the screening of celiac disease in children with type 1 diabetes mellitus.
Authors: Miren Vicuña Arregui; José Manuel Zozaya Urmeneta; Juan Pablo Martínez de Esteban; David Carral Martínez; Javier Pineda Arribas; Lluis Forga Llenas; José María Martínez-Peñuela Virseda; Cristina Rodríguez Gutiérrez; Edelmiro Menéndez Torre; Francisco Javier Jiménez Pérez; Eduardo Layana Echezuri Journal: Gastroenterol Hepatol Date: 2009-10-17 Impact factor: 2.102
Authors: S Sulkanen; T Halttunen; K Laurila; K L Kolho; I R Korponay-Szabó; A Sarnesto; E Savilahti; P Collin; M Mäki Journal: Gastroenterology Date: 1998-12 Impact factor: 22.682
Authors: Santiago Vivas; Jose G Ruiz de Morales; Sabino Riestra; Laura Arias; Dolores Fuentes; Noemi Alvarez; Sara Calleja; Mercedes Hernando; Blanca Herrero; Javier Casqueiro; Luis Rodrigo Journal: World J Gastroenterol Date: 2009-10-14 Impact factor: 5.742
Authors: Satu Simell; Sanna Hoppu; Tuu Simell; Marja-Riitta Ståhlberg; Markku Viander; Taina Routi; Ville Simell; Riitta Veijola; Jorma Ilonen; Heikki Hyöty; Mikael Knip; Olli Simell Journal: Diabetes Care Date: 2010-01-07 Impact factor: 19.112