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Literature DB >> 21567178

Mechanistic insights into chromosome-wide silencing in X inactivation.

Susanne Arthold¹, Agata Kurowski, Anton Wutz.

Abstract

In mammals, one of the two X chromosomes in female cells is transcriptionally silenced for dosage compensation between the sexes. Chromosome-wide silencing is initiated by the non-coding Xist RNA that accumulates within the inactive X chromosome territory and triggers gene repression and chromatin modifications. Epigenetic changes of the inactive X chromosome in a developmentally regulated manner result in stable gene repression in female somatic cells. X inactivation is a model for understanding the formation of facultative heterochromatin in mammalian development and represents a paradigm for RNA mediated regulation of gene expression. In this review, we summarize the present knowledge of the mechanism of chromosome-wide silencing and give an outlook on future directions.

Entities: Chemical

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Year: 2011 PMID： 21567178 DOI： 10.1007/s00439-011-1002-0

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

86 in total

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Authors: Fabio Savarese; Katja Flahndorfer; Rudolf Jaenisch; Meinrad Busslinger; Anton Wutz
Journal: Mol Cell Biol Date: 2006-10 Impact factor: 4.272

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Journal: Nat Genet Date: 2001-08 Impact factor: 38.330

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Authors: Frank O Fackelmayer
Journal: J Biol Chem Date: 2004-11-24 Impact factor: 5.157

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Authors: Winifred Mak; Jonathon Baxter; Jose Silva; Alistair E Newall; Arie P Otte; Neil Brockdorff
Journal: Curr Biol Date: 2002-06-25 Impact factor: 10.834

7. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome.

Authors: C J Brown; A Ballabio; J L Rupert; R G Lafreniere; M Grompe; R Tonlorenzi; H F Willard
Journal: Nature Date: 1991-01-03 Impact factor: 49.962

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Authors: C J Brown; H F Willard
Journal: Nature Date: 1994-03-10 Impact factor: 49.962

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Authors: W M Liu; W M Chu; P V Choudary; C W Schmid
Journal: Nucleic Acids Res Date: 1995-05-25 Impact factor: 16.971

10. The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.

Authors: Dieter Pullirsch; Renate Härtel; Hiroyuki Kishimoto; Martin Leeb; Günter Steiner; Anton Wutz
Journal: Development Date: 2010-02-11 Impact factor: 6.868

14 in total

1. Mary Lyon and the hypothesis of random X chromosome inactivation.

Authors: Peter S Harper
Journal: Hum Genet Date: 2011-08 Impact factor: 4.132

2. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome.

Authors: Jesse M Engreitz; Amy Pandya-Jones; Patrick McDonel; Alexander Shishkin; Klara Sirokman; Christine Surka; Sabah Kadri; Jeffrey Xing; Alon Goren; Eric S Lander; Kathrin Plath; Mitchell Guttman
Journal: Science Date: 2013-07-04 Impact factor: 47.728

3. Genomic aberrations in an African American colorectal cancer cohort reveals a MSI-specific profile and chromosome X amplification in male patients.

Authors: Hassan Brim; Edward Lee; Mones S Abu-Asab; Mohamed Chaouchi; Hadi Razjouyan; Hassanzadeh Namin; Ajay Goel; Alejandro A Schäffer; Hassan Ashktorab
Journal: PLoS One Date: 2012-08-06 Impact factor: 3.240

10. Human 45,X fibroblast transcriptome reveals distinct differentially expressed genes including long noncoding RNAs potentially associated with the pathophysiology of Turner syndrome.

Authors: Shriram N Rajpathak; Shamsudheen Karuthedath Vellarikkal; Ashok Patowary; Vinod Scaria; Sridhar Sivasubbu; Deepti D Deobagkar
Journal: PLoS One Date: 2014-06-16 Impact factor: 3.240