| Literature DB >> 21565454 |
Shaoxin Cai1, Jun Li, Mabel Ting Wong, Peirong Jiao, Huiying Fan, Dawei Liu, Ming Liao, Jingwei Jiang, Mang Shi, Tommy Tsan-Yuk Lam, Tao Ren, Frederick Chi-Ching Leung.
Abstract
Complete genomes of four Newcastle disease virus (NDV) strains, isolated from ducks and wild birds in Guangdong province of China from 2003 to 2007, were sequenced and analyzed in this study. Pathogenicity tests in chicken embryos and chickens illustrate that D3 and R8 are lentogenic, and W4 and P4 are mesogenic strains. Phylogenetic analysis using all six genes provides a high resolution profile for genotype designation as genotype I for D3 and R8 strains and genotype VI for W4 and P4 strains. In addition, molecular dating based on different genes suggests that D3 and R8 diverged from their common ancestor at around 1998; W4 and P4 diverged from their common ancestor at around 1999. Subsequent selective pressure analysis displayed specific traits of genes evolution in all 4 strains since their divergence from the recent common ancestor. Furthermore, the geographic origins of 4 strains were deduced to be from Europe via two independent introduction events by phylogeographical analysis. This provides insights to the potential influence of waterfowl migration on NDV epidemiology.Entities:
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Year: 2011 PMID： 21565454 DOI： 10.1016/j.vetmic.2011.04.014
Source DB: PubMed Journal: Vet Microbiol ISSN： 0378-1135 Impact factor: 3.293