Literature DB >> 21565410

Altered expression and secretion of colonic interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction.

Dervla O'Malley1, Timothy G Dinan, John F Cryan.   

Abstract

Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than control Sprague Dawley (SD) colons (5.55 pg/ml) and WKY secretions stimulated calcium responses in naïve submucosal neurons of greater amplitude. Recombinant IL-6 activated more submucosal neurons in WKY tissue preparations (p<0.05). These data demonstrate that WKY colonic supernatants activate submucosal neurons using an IL-6-dependent mechanism, thereby providing a link between gastrointestinal dysfunction and alterations in IL-6 levels.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 21565410     DOI： 10.1016/j.jneuroim.2011.04.003

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  13 in total

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3.  Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome.

Authors:  Maria M Buckley; Ken D O'Halloran; Mark G Rae; Timothy G Dinan; Dervla O'Malley
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Review 4.  The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?

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Review 6.  The Role of Inflammatory Mediators in the Development of Gastrointestinal Motility Disorders.

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Review 8.  Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome.

Authors:  Maria M Buckley; Siobhain M O'Mahony; Dervla O'Malley
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9.  Interleukin-6 modulates colonic transepithelial ion transport in the stress-sensitive wistar kyoto rat.

Authors:  Dervla O'Malley; Timothy G Dinan; John F Cryan
Journal:  Front Pharmacol       Date:  2012-11-07       Impact factor: 5.810

10.  Neonatal maternal separation increases susceptibility to experimental colitis and acute stress exposure in male mice.

Authors:  Isabella M Fuentes; Natalie K Walker; Angela N Pierce; Briana R Holt; Elizabeth R Di Silvestro; Julie A Christianson
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