| Literature DB >> 2156531 |
T Himi1, H Saito, N Kawai, T Nakajima.
Abstract
The effect of a spider toxin (JSTX-3)--a specific blocker of glutamate receptors--on the behavior of mice was studied using an intracerebroventricular (i.c.v.) injection technique. At higher doses (more than 12 nmol/brain), JSTX-3 increased motor activities and induced characteristic symptoms. JSTX-3 at a dose of 4.7 nmol/brain which per se did not produce any abnormal behavior, specifically antagonized quisqualate-induced convulsions but not NMDA- or kainate-induced convulsions. These results indicate that JSTX-3 is a selective antagonist of the quisqualate receptors in the mammalian central nervous system.Entities:
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Year: 1990 PMID： 2156531 DOI： 10.1007/BF01257076
Source DB: PubMed Journal: J Neural Transm Gen Sect