Literature DB >> 2156194

Tetanus toxin produces neuronal loss and a reduction in GABAA but not GABAB binding sites in rat hippocampus.

G Bagetta1, C Knott, G Nisticó, N G Bowery.   

Abstract

The neuropathological effects of tetanus toxin, microinjected in the rat CA1 hippocampal area, were studied by using a microscopical and autoradiographical approach. Tetanus toxin produced a dose- and time-dependent neuronal loss in the CA1 area accompanied by a reduction in the binding of gamma-[3H]aminobutyric acid ([3H]GABA) to GABAA but not GABAB sites in the pyramidal cell layer.

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Year:  1990        PMID： 2156194     DOI： 10.1016/0304-3940(90)90529-i

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  4 in total

1.  Gliosis in the mouse hippocampus without neuronal death after systemic administration of high dosage of tetanus toxin.

Authors:  Seung Min Park; Bing Chun Yan; Joon Ha Park; Jung Hoon Choi; Ki-Yeon Yoo; Choong Hyun Lee; Yi-Young Baek; Young-Myeong Kim; Il-Jun Kang; Moo-Ho Won
Journal:  Cell Mol Neurobiol       Date:  2011-12-03       Impact factor: 5.046

2.  Chronological changes in inflammatory cytokines immunoreactivities in the mouse hippocampus after systemic administration of high dosage of tetanus toxin.

Authors:  Bing Chun Yan; Joon Ha Park; In Hye Kim; Bich Na Shin; Ji Hyeon Ahn; Ki-Yeon Yoo; Deuk-Sik Lee; Myong Jo Kim; Il-Jun Kang; Moo-Ho Won
Journal:  Exp Brain Res       Date:  2012-09-19       Impact factor: 1.972

3.  Prevention by the NMDA receptor antagonist, MK801 of neuronal loss produced by tetanus toxin in the rat hippocampus.

Authors:  G Bagetta; G Nisticò; N G Bowery
Journal:  Br J Pharmacol       Date:  1990-12       Impact factor: 8.739

4.  Systemic administration of low dosage of tetanus toxin decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus.

Authors:  Bing Chun Yan; In Hye Kim; Joon Ha Park; Ji Hyeon Ahn; Jeong-Hwi Cho; Bai Hui Chen; Jae-Chul Lee; Jung Hoon Choi; Ki-Yeon Yoo; Choong Hyun Lee; Jun Hwi Cho; Jong-Dai Kim; Moo-Ho Won
Journal:  Lab Anim Res       Date:  2013-09-27
  4 in total

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