OBJECTIVE: To assess the effects of second generation antipsychotics on neurocognitive function in patients with stable remission of first episode psychosis. METHODS:Fifty-three patients with first onset psychosis in the schizophrenia spectrum entered a randomised controlled trial of guided discontinuation (GD) versus maintenance treatment (MT) with second generation antipsychotics. A comprehensive neurocognitive test battery was administered at the time of remission and shortly after dose reduction or discontinuation (GD-group) or at the same time in the MT-group. RESULTS: With the exception of negative symptoms, PANSS scores decreased over time and neurocognition improved significantly on most tests in both groups. The GD-group, however, improved significantly more than the MT-group on three neurocognitive measures in the domain of speed of processing. CONCLUSION: These data suggest that, in first episode patients, dose reduction or discontinuation of second generation antipsychotics after stable remission is achieved, might improve neurocognitive function more than continuing second generation antipsychotics, suggesting a negative role for second generation antipsychotics, specifically in the domain of speed of processing.
RCT Entities:
OBJECTIVE: To assess the effects of second generation antipsychotics on neurocognitive function in patients with stable remission of first episode psychosis. METHODS: Fifty-three patients with first onset psychosis in the schizophrenia spectrum entered a randomised controlled trial of guided discontinuation (GD) versus maintenance treatment (MT) with second generation antipsychotics. A comprehensive neurocognitive test battery was administered at the time of remission and shortly after dose reduction or discontinuation (GD-group) or at the same time in the MT-group. RESULTS: With the exception of negative symptoms, PANSS scores decreased over time and neurocognition improved significantly on most tests in both groups. The GD-group, however, improved significantly more than the MT-group on three neurocognitive measures in the domain of speed of processing. CONCLUSION: These data suggest that, in first episode patients, dose reduction or discontinuation of second generation antipsychotics after stable remission is achieved, might improve neurocognitive function more than continuing second generation antipsychotics, suggesting a negative role for second generation antipsychotics, specifically in the domain of speed of processing.
Authors: Stefan Leucht; Inge Winter-van Rossum; Stephan Heres; Celso Arango; W Wolfgang Fleischhacker; Birte Glenthøj; Marion Leboyer; F Markus Leweke; Shôn Lewis; Phillip McGuire; Andreas Meyer-Lindenberg; Dan Rujescu; Shitij Kapur; René S Kahn; Iris E Sommer Journal: Schizophr Bull Date: 2015-03-18 Impact factor: 9.306
Authors: Marieke J H Begemann; Ilse A Thompson; Wim Veling; Shiral S Gangadin; Chris N W Geraets; Erna van 't Hag; Sanne J Müller-Kuperus; Priscilla P Oomen; Alban E Voppel; Mark van der Gaag; Martijn J Kikkert; Jim Van Os; H Filip E Smit; Rikus H Knegtering; Sybren Wiersma; Luyken H Stouten; Harm J Gijsman; Lex Wunderink; Anton B P Staring; Selene R T Veerman; Amrita G S Mahabir; Jörg Kurkamp; Gerdina H M Pijnenborg; Natalie D Veen; Machteld Marcelis; Koen P Grootens; Gunnar Faber; Nico J van Beveren; Agaath Been; Truus van den Brink; Maarten Bak; Therese A M J van Amelsvoort; Andrea Ruissen; Christine Blanke; Karin Groen; Lieuwe de Haan; Iris E C Sommer Journal: Trials Date: 2020-02-07 Impact factor: 2.279
Authors: Timo Beeker; China Mills; Dinesh Bhugra; Sanne Te Meerman; Samuel Thoma; Martin Heinze; Sebastian von Peter Journal: Front Psychiatry Date: 2021-06-04 Impact factor: 4.157