Literature DB >> 2156136

Valproyl CoA: an active metabolite of valproate?

P Friel1.   

Abstract

Valproic acid exhibits a time course of antiepileptic effects suggesting a major role for active metabolites. It is proposed that valproyl-CoA, a valproate metabolite previously identified in liver, may accumulate in brain as a result of normal fatty acid turnover processes. Valproyl CoA could contribute to valproate's antiepileptic activity by stimulating Na+, K+-ATPase activity when brain ATP concentration is low.

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Year:  1990        PMID： 2156136     DOI： 10.1016/0306-9877(90)90049-k

Source DB:  PubMed          Journal:  Med Hypotheses        ISSN： 0306-9877            Impact factor:   1.538


  3 in total

1.  Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder.

Authors:  Richard P Bazinet; Margaret T Weis; Stanley I Rapoport; Thad A Rosenberger
Journal:  Psychopharmacology (Berl)       Date:  2005-12-13       Impact factor: 4.530

2.  Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat.

Authors:  Richard P Bazinet; Jagadeesh S Rao; Lisa Chang; Stanley I Rapoport; Ho-Joo Lee
Journal:  Psychopharmacology (Berl)       Date:  2005-09-29       Impact factor: 4.530

3.  Valproyl-CoA and esterified valproic acid are not found in brains of rats treated with valproic acid, but the brain concentrations of CoA and acetyl-CoA are altered.

Authors:  Joseph Deutsch; Stanley I Rapoport; Thad A Rosenberger
Journal:  Neurochem Res       Date:  2003-06       Impact factor: 3.996
  3 in total

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