AIM: To study the serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance. METHODS: 40 patients with ulcerative colitis as UC group and 30 healthy people as control group were selected. The serum contents of IL-23 and IL-17 were determined bII ELISA. RESULTS: Serum contents of IL-23 AND IL-17 in UC group were higher than those in control group significantly (t=18.76, 21.48, P<0.01). Serum contents of IL-23 and IL-17 increase with the clinical symptoms. Serum contents of IL-23 AND IL-17 in severe patients were higher than those of mild and moderate patients significantly, and serum contents of IL-23 and IL-17 in mild patients were higher than those of moderate patients significantly. Serum contents of IL-23 were positively correlated to IL-17 significantly (r=0.548, P<0.01). CONCLUSION: IL-23 and IL-17 participates in the pathogenesis of ulcerative colitis. IL-23 may play a critical role in the development of UC through inducing production of IL-17.
AIM: To study the serum contents of IL-23 and IL-17 in the patients with ulcerative colitis and the clinical significance. METHODS: 40 patients with ulcerative colitis as UC group and 30 healthy people as control group were selected. The serum contents of IL-23 and IL-17 were determined bII ELISA. RESULTS: Serum contents of IL-23 AND IL-17 in UC group were higher than those in control group significantly (t=18.76, 21.48, P<0.01). Serum contents of IL-23 and IL-17 increase with the clinical symptoms. Serum contents of IL-23 AND IL-17 in severe patients were higher than those of mild and moderate patients significantly, and serum contents of IL-23 and IL-17 in mild patients were higher than those of moderate patients significantly. Serum contents of IL-23 were positively correlated to IL-17 significantly (r=0.548, P<0.01). CONCLUSION:IL-23 and IL-17 participates in the pathogenesis of ulcerative colitis. IL-23 may play a critical role in the development of UC through inducing production of IL-17.
Authors: Tamer A Gheita; Iman I El Gazzar; Hussein S El-Fishawy; Mohamed A Aboul-Ezz; Sanaa A Kenawy Journal: Clin Rheumatol Date: 2014-01-03 Impact factor: 2.980
Authors: Julajak Limsrivilai; Krishna Rao; Ryan W Stidham; Shail M Govani; Akbar K Waljee; Andrew Reinink; Laura Johnson; Emily Briggs; Peter D R Higgins Journal: Dig Dis Sci Date: 2018-04-12 Impact factor: 3.199