BACKGROUND: A wound is a clinical entity which often poses problems in clinical practice. The present study was aimed to investigate the wound healing potential of administering marine collagen peptides (MCP) from Chum Salmon skin by using two wound models (incision and excision) in rats. RESULTS: Ninety-six animals were equally divided into the two wound models and then within each model animals were randomly divided into two groups: vehicle-treated group and 2 g kg(-1) MCP-treated group. Wound closure and tensile strength were calculated. Collagen deposition was assessed by Masson staining and hydroxyproline measurement. Angiogenesis was assessed by immunohistological methods. MCP-treated rats showed faster wound closure and improved tissue regeneration at the wound site, which was supported by histopathological parameters pertaining to wound healing. MCP treatment improved angiogenesis and helped form thicker and better organised collagen fibre deposition compared to vehicle-treated group. CONCLUSION: The results show the efficacy of oral MCP treatment on wound healing in animals.
BACKGROUND: A wound is a clinical entity which often poses problems in clinical practice. The present study was aimed to investigate the wound healing potential of administering marine collagen peptides (MCP) from Chum Salmon skin by using two wound models (incision and excision) in rats. RESULTS: Ninety-six animals were equally divided into the two wound models and then within each model animals were randomly divided into two groups: vehicle-treated group and 2 g kg(-1) MCP-treated group. Wound closure and tensile strength were calculated. Collagen deposition was assessed by Masson staining and hydroxyproline measurement. Angiogenesis was assessed by immunohistological methods. MCP-treated rats showed faster wound closure and improved tissue regeneration at the wound site, which was supported by histopathological parameters pertaining to wound healing. MCP treatment improved angiogenesis and helped form thicker and better organised collagen fibre deposition compared to vehicle-treated group. CONCLUSION: The results show the efficacy of oral MCP treatment on wound healing in animals.
Authors: Dhara Patel; Tae Jin Lee; Sandeep Kumar; Sagar Vyavahare; Alison Worth; William D Hill; Mark Hamrick; Carlos M Isales; Rahul S Shinde; Sadanand Fulzele Journal: Biogerontology Date: 2022-09-02 Impact factor: 4.284
Authors: Chiara De Luca; Elena V Mikhal'chik; Maxim V Suprun; Michael Papacharalambous; Arseniy I Truhanov; Liudmila G Korkina Journal: Oxid Med Cell Longev Date: 2016-01-19 Impact factor: 6.543
Authors: Fazli Subhan; Hae Yeong Kang; Yeseon Lim; Muhammad Ikram; Sun-Yong Baek; Songwan Jin; Young Hun Jeong; Jong Young Kwak; Sik Yoon Journal: Oxid Med Cell Longev Date: 2017-06-22 Impact factor: 6.543