Literature DB >> 21559724

Coamplification in human breast-tumors and physical linkage at chromosomal band 12p13, of ccnd2 and fgf6 genes.

A Dib1, J Adelaide, F Courjal, A Courseaux, J Jacquemier, P Gaudray, C Theillet, M Pebusque, D Birnbaum.   

Abstract

The CCND2 and FGF6 genes are both located at band p13 of human chromosome 12. The two genes are coamplified in some cases (3.6%) of breast tumors. They are physically linked within a 500 kb genomic segment. Thus, both 11q13 and 12p13 chromosomal regions host related linked cyclin and FGF genes, and can be amplified in human tumors. This strengthens the hypothesis of genome duplication involving chromosomes 11 and 12.

Entities:  

Year:  1994        PMID： 21559724     DOI： 10.3892/ijo.5.6.1375

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  2 in total

1.  Cytogenetic studies on a patient with prepubertal breast cancer: a case report.

Authors:  B R Balsara; T Varughese; A V Bhat; R S Rao; A N Bhisey
Journal:  Breast Cancer Res Treat       Date:  1996       Impact factor: 4.872

2.  Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers.

Authors:  Anne Letessier; Fabrice Sircoulomb; Christophe Ginestier; Nathalie Cervera; Florence Monville; Véronique Gelsi-Boyer; Benjamin Esterni; Jeannine Geneix; Pascal Finetti; Christophe Zemmour; Patrice Viens; Emmanuelle Charafe-Jauffret; Jocelyne Jacquemier; Daniel Birnbaum; Max Chaffanet
Journal:  BMC Cancer       Date:  2006-10-13       Impact factor: 4.430
  2 in total

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