Brief Strategic Therapy vs Cognitive Behavioral Therapy for the Inpatient and Telephone-Based Outpatient Treatment of Binge Eating Disorder: The STRATOB Randomized Controlled Clinical Trial.

This paper describes the results of the STRATOB (Systemic and STRATegic psychotherapy for OBesity) study, a two-arm randomized controlled clinical trial (RCT) comparing Brief Strategic Therapy (BST, Nardone or Arezzo model) with the gold standard CBT (Cognitive Behavioral Therapy) for the inpatient and telephone-based outpatient treatment of obese people with Binge Eating Disorder (BED) seeking treatment for weight reduction. Primary outcome measure of the randomized trial was change in the Global Index of the Outcome Questionnaire (OQ 45.2). Secondary outcome measures were BED remission (weekly binge episodes < 2) and weight loss. Data were collected at baseline, at discharge from the hospital (c.a. 1 month after) and after 6 months from discharge.. No significant difference between groups (BST vs CBT) was found in the primary outcome at discharge. However, a greater improvement was seen in the BST vs the CBT group (P<.01) in the primary outcome at 6 months. About secondary outcomes, no significant difference between groups were found in weight change both at discharge and at 6 months. Notably, a significant association emerged between treatment groups and BED remission at 6 months in favor of BST (only 20% of patients in BST group reported a number of weekly binge episodes > 2 vs 63.3% in CBT group).

RCT Entities:   Population Interventions Outcomes

INTRODUCTION

Obesity constitutes one of the most important medical and public health problems of our time [1]. It is considered as a chronic pathology and is widely recognized as a risk factor for many medical complications such as cardiovascular, orthopedic, pneumological and endocrinological diseases [2-8]. Overweight and obesity is also linked with Binge Eating Disorder (BED). “Binge eating disorder is characterized by frequent and persistent episodes of binge eating accompanied by feelings of loss of control and marked distress in the absence of regular compensatory behaviors” (p. 94. [9]). Functional interventions for significantly reduce weight, maintain weight loss and manage associated pathologies like BED are tipically combined treatment options (dietetic, nutritional, physical, behavioral, cognitive-behavioral, pharmacological, surgical). Significant difficulties with regard to availability, costs, treatment adherence and long-term efficacy are present [10]. Moreover, most overweight and obese individuals regain about one third of the weight lost with treatment within 1 year [11] and they are typically back to baseline in 3 to 5 years [12-14].

Treatment for BED is directed towards either the physical or psychopathological impairments and Cognitive behavior therapy (CBT) and Interpersonal Psychotherapy (IPT) are psychotherapies for BED indicated to target the eating disorder [9]. Particularly CBT is the therapeutic approach indicated both in inpatient and in outpatient settings for BED [15-27]. In recent years systemic and systemic-strategic psychotherapies have been implemented to treat patients with obesity and BED involved in familiar problems [26-30]. Particularly, a brief protocol for the systemic-strategic treatment of BED, using overall the strategic dialogue, has been developed by Nardone and Portelli in the Handbook of Brief Strategic Therapy (BST) [31].

Furthermore, telemedicine, a new promising low cost method, has been used for obesity with BED in outpatient settings in order to avoid relapse after the inpatient step of treatment and to keep on a continuity of care with the involvement of the same clinical inpatient team [32-35].

For these reasons, we developed STRATOB (Systemic and STRATegic psychotherapy for OBesity), a comprehensive two-phase stepped down program enhanced by telepsychology for the mid-term treatment of obese people with BED seeking intervention for weight loss. The core aspects of STRATOB are the inpatient intensive treatment and the continuity of care at home using a low-level of telecare (mobile phones). Many treatments delivered using technologies, such as web-sites, e-mails, chat lines, videoconferences, UMTS-based mobile-phones and telephones, could be a valid integration to traditional psychotherapy reducing expensive and time-consuming clinical visits and improving adherence to prescribed psychological, dietetic and medical treatments through extensive monitoring and support [10, 12, 36-41].

This paper describes the design and the results of the STRATOB study, a two-arm randomized controlled clinical trial (RCT). The aims of this study are to compare the effectiveness of the BST [31, 42, 43] with the gold standard CBT [26, 44-50] in a inpatient and telephone-based outpatient program for a sample of obese people with BED seeking treatment for weight reduction.

MATERIALS AND METHODOLOGY

Study Design and Protocol

CBT and BST have been compared in a randomized controlled clinical trial. Participants have been randomly allocated in 2 groups:

CBT group: inpatient treatment (diet, physical activity, dietitian counseling, 8 sessions of CBT) plus 8 outpatient telephone-based sessions of CBT-oriented psychological support and monitoring with the same CBT inpatient psychotherapists;

BST group: inpatient treatment (diet, physical activity, dietitian counseling, 8 sessions of BST) plus 8 outpatient telephone-based sessions of BST-oriented psychological support and monitoring with the same BST inpatient psychotherapists;

The Medical Ethics Committee of Istituto Auxologico Italiano approved the study protocol and the Informed Consents.

The treatment program considered in this study has a total duration of 7 months and consists of two stepped down phases: in-patient (1 month) and out-patient (the following 6 months). During the in-patient phase, participants undergo an intensive four-week hospital-based and medically-managed program for weight reduction and rehabilitation. Along this period, participants live in a medical hospital-like environment located on a mountain highland and far away from towns and cities. Visits from parents are allowed only in the afternoon. All patients are placed on a hypocaloric nutritionally balanced diet tailored to the individual after consultation with a dietitian (energy intake around 80% of the basal energy expenditure estimated according to the Harris-Benedict equation and a macronutrient composition of about 16% proteins, 25% fat and 59% carbohydrates). Furthermore, they receive nutritional counseling provided by a dietitian, psychotherapy provided by psychologists-psychotherapists (well trained in CBT and BST approaches) and have physical activity training provided by a physiotherapist.

Nutritional rehabilitation program aims to improve and promote change in eating habits and consists of both individual sessions (dietary assessment, evaluation of nutrient intake and adequacy, nutritional status, anthropometric, eating patterns, history of overweight, readiness to adopt change) and group sessions (45 minutes each twice a week) including: information on obesity and related health risks, setting of realistic goals for weight loss, healthy eating in general, general nutrition and core food groups, weight management and behavior change strategies for preventing relapse).

Psychotherapy is provided twice a week in a face-to-face setting. CBT individual sessions, lasting 45 minutes each, are mainly based on the cognitive-behavioral approach described by Cooper and Fairburn [50] and emphasize the techniques of self-monitoring, goal setting, time management, prompting and cueing, problem solving, cognitive restructuring, stress management and relapse prevention. BST individual sessions, lasting 45 minutes each, are mainly based on the brief strategic approach described by Nardone and Portelli [31] and emphasize the techniques of working on “attempted solutions” (such as keeping control by abstaining from food and continuously striving to exert self-control with a subsequent loss of control), using reframing maneuvers, inducing fear of fasting rather then bingeing, understanding what is maintaining and worsening the problem, etc. (p. 105-105, [31]).

Physical activity takes place once a day except for week-end and consists of group programs (20 subjects) based on postural gymnastics, aerobic activity and walks in the open. Inpatients with specific orthopedic complications carry out individual activities planned by physiotherapists and articulated in programs of physical therapy, assisted passive and active mobilization and isokinetic exercise.

Low to moderate weight losses are expected at the end of the in-patient phase, but it is important to note that weight loss is not the primary goal of the in-patient program and each patient is made clear about this point at the very beginning of the treatment. Beyond the medical management of metabolic risk factors for health such as type 2 diabetes, developing a sense of autonomy and competence are the primary purposes of the in-hospital interventions. Patients are afforded the skills and tools for change and are supported in assigning positive values to healthy behaviors and also in aligning them with personal values and lifestyle patterns.

Just after discharge, participants have 4 telephone calls with their psychotherapists along 2 months. From the 3rd to the 6th month sessions are scheduled every 30 days. During tele-sessions, psychotherapists test the outpatients’ progress, their mood, the maintenance of the “good alimentary and physical activity habits”, the loss/increase of weight and ask about critical moments. Some research indicates that changes in behavior (eating and exercise) often follow discrete moments which have been variably described as life events, life crises, teachable moments or epiphanies [51]. Life events can lead to weight loss but also to weight gain and qualitative research shows that it is not the event per se that results in behavior change but the ways in which this event is appraised and interpreted by the individual [52]. The psychotherapists (both CBT and BST) have thus the opportunity to discuss with the outpatients about the significant events during the telephone calls and cognitively reconstruct dysfunctional appraisals in functional ways.

In particular, phone-sessions with the psychotherapists aim to consolidate strategies and abilities acquired during the in-patient phase, to improve self-esteem and self-efficacy, to support motivation, to prevent relapse and to provide problem-solving and crisis counseling.

As described, in the outpatient phase of the STRATOB program great relevance is given to the psychotherapist-patient relationship as an important medium and vehicle of change [53]. After discharge, out-patients begin to experience the autonomy and competence to change they develop during the in-patient phase and inevitably face resistances and barriers. Thanks to telephone calls, out-patients are supported by the psychotherapists who attended them during the in-hospital phase in exploring resistances and barriers they experience and in finding functional pathways to cope. Furthermore, out-patients are helped to experience mastery in terms of the health behavior change that needs to be engaged.

Study Population

Recruitment of the Study Population

One hundred consecutive female inpatients with obesity and BED in the age range of 18-65 years who were referred to the single clinical center (Saint Joseph Hospital - Istituto Auxologico Italiano) for weight-loss treatment have been asked and screened for admission to the study. Patients were sequentially recruited in 2008. Of these, 37 did not fulfill inclusion criteria and 7 declined to partecipate for other reasons (e.g., time constraints, involvement in other treatments). Finally, 60 patients (mean age: 46.05 ± 10.54 years; mean weight: 106.95 ± 6.94 kg) entered the treatment phase.

Inclusion and Exclusion Criteria

Inpatients were eligible when they met the following inclusion criteria at the admission to the hospital: 1) age between 18 and 65 years; 2) obesity according to the WHO criteria (BMI≥30); 3) BED (DSM-IV-TR criteria) and 4) written and informed consent to participate. Exclusion criteria for the study are: 1) other severe psychiatric disturbance diagnosed by DSM-IV-TR criteria; 2) concurrent medical condition not related to obesity. SCID (Structured Clinical Interview for DSM-IV-TR Disorders) I and II [54] were used as screening tools for psychiatric disorders and were administered by an independent clinical psychologist as part of his work.

Randomization Procedure

All participants were randomly assigned to the CBT or BST group. The randomization scheme have been generated by using the Web site Randomization.com (www. randomization.com). Randomization took place after the baseline measurements.

Psychotherapists and Treatment Fidelity

Treatments were delivered by 4 experienced and chartered psychotherapists from diverse backgrounds with specific training in CBT and BST. Psychotherapists received monthly supervision by senior chartered psychotherapists to ensure competent and uniform treatment delivery.

Patient Assessment and Measurements

Primary outcome measure of the randomized trial is change in the Global Index of the Outcome Questionnaire (OQ 45.2). Secondary outcome measures are BED remission defined as a number of weekly binge episodes < 2 and weight loss. Data were collected at baseline, at discharge from the hospital (c.a. 1 month after) and after 6 months from discharge.

Weight was assessed with the participant in lightweight clothing with shoes removed on a balance beam scale. Data collected at 6-month follow-up were collected through tele-sessions.

Psychological and Behavioral Assessment

Participants completed the Outcome Questionnaire (OQ 45.2) – Italian translation and validation [55, 56] at entry to the study and at discharge from the hospital with a self-report procedure. At 6-month follow-up data have been collected via telephone during the tele-sessions.

The OQ 45.2 is an self report questionnaire developed by Michael Lambert in 1996 [57]. The OQ 45 items version is a measure of outcome and it is designed in order to collect repeated measures of patient progress during psychotherapy and after its conclusion. This instrument is one of the most used in psychotherapy research in the U.S. [58]. The OQ 45.2 is composed by 45 items that form 3 scales: Symptom Distress (SD), Interpersonal Relations (IR) e Social Role (SR), and a Global Index. The OQ 45.2 is proposed as a brief screening and outcome scale that tries to assess the subjective experience of a person, as well as the way he or she functions in the world [57]. The choice of this questionnaire has to take into account the need to measure a change in a short time (1 month of in-patient treatment) due to psychotherapeutic activities. The Italian version of the OQ-45.2 appears promising as a measure of general psychological distress, and it could be used to measure the psychotherapy outcome in routine clinical practice. So the Outcome Questionnaire-45 was developed as a brief measure of client progress in psychotherapy to address the need for accountability in the era of managed care and to improve upon extant outcome measures.

Number of weekly binge episodes was assessed with a self-report procedure at entry to the study and at discharge from the hospital. At 6-month follow-up, data have been collected via telephone during the tele-sessions.

Sample Size Calculation and Statistical Analysis

Due to the novelty of the application of BST in BED treatment, no other RCTs including BST have been carried out. So this RCT is similar to a pilot study, typically defined as small scale preliminary study, and according to Lackey and Wingate [59], a pilot work may use at least the 10% of the sample required. Using an A-priori Sample Size Calculator for Student's t-Test (G*Power 3.1.2 software), 64 participants per group were needed to detect a difference with an estimated Effect Size (Cohen's d) of 0.5, an alpha of 0.05 two-sided, a desired statistical power of 0.80. We decided not to make assumptions on sidedness not having previous results about comparison between CBT and BST. Taking into account the need of at least 10% of the sample required (128 individuals, n=64 per group), 60 persons (n=30 per group) were considered enough.

Descriptive statistics (means ± SD) have been used to describe the study sample with regard to baseline characteristics (Table ). The independent samples t test was used to examine between-group differences in OQ variables and weight at all time-points. Change scores were also examined. Chi-square was used to test the association between treatment groups and number of weekly binge episodes ≥ 2 at 6 months. Corrected effect sizes (Hedges) and 95% Confidence Interval were calculated for both between-group and with-in group differences. All data analyses were performed using the Statistical Package for the Social Sciences (version 16.0; SPSS, Inc., Chicago, IL).

RESULTS

There were no differences between CBT and BST on any demographic, diagnostic and other clinical variable at pretreatment (Table ).

No significant between-group difference was found in change scores from baseline to discharge in any variables (Table ). At 6 months, OQ 45.2 Global Index as well as the OQ 45.2 Symptom Distress (SD) change scores from discharge were higher in the BST vs the CBT group (p<0,000) (Table and Fig. ).

Table shows the within-group changes for all the variables at all time-points. BST group had statistically significant improvements from baseline to discharge as well as from discharge to 6-month follow-up in all continuous outcomes. CBT group had significant improvements on all the variables but not in the OQ 45.2 Interpersonal Relations (IR) change from Baseline to Discharge, in the OQ 45.2 Interpersonal Relations (IR) change from Discharge to 6 months and in Percentage of weight loss from discharge to 6 months (95% confidence intervals of mean changes include zero).

With respect to absolute weight loss, no significant between-group difference was found in weight loss from baseline to discharge and from discharge to 6 months (Fig. ). A significant association was found between treatment groups and BED remission at 6 months (Fig. ). In the BST group, only 20% of participants vs 63,3% in the CBT group (p=0,001) reported a number of weekly binge episodes over the cut-off (>2) for the BED diagnosis.

DISCUSSION AND LIMITATIONS

Due to the novelty of Brief Strategic Therapy (BST) in the treatment of Binge Eating Disorder, no well defined hypothesis have been established about the possible contribution of this kind of therapy in comparison with Cognitive Behavior Therapy (CBT), the “gold standard” psychological treatment for BED. With the development of a brief systemic-strategic clinical protocol for treatment of BED [31], new interventions in the field of eating disorders are available and have to be evaluated. Systemic and systemic-strategic psychotherapies such as BST traditionally focus on systemic-family problems and contexts and these areas of interventions could represent a real added value in comparison with CBT.

Moreover, BST sessions emphasize the techniques of working on “attempted solutions”, using reframing maneuvers, inducing fear of fasting rather then bingeing, understanding what is maintaining and worsening the problem, etc. (p. 105-106, [31]). This focus on “attempted solutions”, that in the typical BED are related to dysfunctional habits such as “trying to keep control by abstaining from food and continuously striving to exert self-control with a subsequent loss of control”, could explain the observed superiority of BST vs CBT in producing a significant remission of weekly binge episodes at 6 months. During the inpatient phase patients did not cope with the binge temptations due to the lack of them in a safe place like the hospital. However, after discharge, patients went back home and faced again with their temptations. BST suggestions about managing binge eating was proved to be more effective in preventing relapse than CBT after 6 months from discharge.

The other significant difference in favor of BST, i.e. the higher improvement in the OQ 45.2 Global Index at 6 months, is probably due to the focus of BST on symptoms reduction (in particular anxiety and depression) in short time (traditionally 6-months). Indeed, a significant difference between CBT and BST was found also in the OQ 45.2 Symptom Distress (SD) scale, where greater improvements were seen in the BST vs the CBT group (p<.01).

The real therapeutic impact of CBT and BST could have been significantly reduced by the use of an unusual setting in the second phase of the trial. Even if telecare could represent a great opportunity for the continuity of treatments “moving the healthcare where it really needs”, the limitations of non-verbal communications, due to the use of telephone sessions, could have influenced the CBT and BST protocols in different ways that have to be investigated in future researches.

Another study limitation concerns the low number of psychometric tools used in the evaluation of change. Even if the the OQ 45.2 is designed to collect repeated measures of patient progress during psychotherapy and after its conclusion, no specific scale or questionnaire was used to assess the eating dysfunctional area of patients. Number of weekly binge episodes was used as a simple index for BED remission and data showed that BST was more effective than CBT in preventing relapse, but in future trials the more reliable number of weekly binge days (and not the number of weekly binge episodes, as suggested by Wilson and Sysko [60]) should be used.

A final limitation is small sample size. Even if this is the first study that compared CBT with BST in the treatment of BED, larger clinical trials are needed in order to evaluate both the effectiveness of integrated psychotherapies (such as the traditional CBT combined with BST or IPT) and the use of new technologies in the clinical field (from the “low technology” telephone to the “medium technology” clinically oriented SMS, MMS, e-mail, chat, web sources, till the “high technology” web 2.0 or virtual and augmented realities) [61-67].

Given that the STRATOB trial was a single-centre randomized controlled study, generalization of research findings is limited. Future multi-centre trials should extend both the use of alternative models of psychological support or psychotherapy, i.e. BST, and the implementation of new technologies in order to find the best combination of the variables involved (psychotherapeutic model, level of technology, number of sessions, etc.).

Considering that traditional interventions for BED patients with obesity typically fails because of low compliance with clinical programs, continuous monitoring and psychological support are needed. This study improved the evidence-based knowledge of how CBT and BST may enhance the long-term efficacy of clinical interventions for BED and weight loss also using telecare settings. Due to the growing development of technologies in the clinical applications, we are moving towards a new “health care everywhere” approach, where clinicians could provide their treatments in both traditional clinical settings (public and private hospitals, clinics, services, etc.) and innovative clinical settings (remote outpatients’ clinics, tele-health and e-health based settings).

Table 1

Baseline Participant Characteristics by Treatment Group

Characteristic	CBT Group (n = 30)	BST Group (n = 30)	Total (N = 60)
Age, y *	46,2 (10,5)	45,9 (10,76)	46,05 (10, 54)
Female sex	30	30	60
Weight, Kg *	107, 37 (6,83)	106,53 (7,14)	106,95 (6,95)
OQ 45.2 Symptom Distress (SD) *	48,47 (8,42)	52,13 (11,19)	50,3 (10)
OQ 45.2 Interpersonal Relations (IR) *	24,40 (5,8)	25,93 (7,61)	25,17 (6,75)
OQ 45.2 Social Role (SR) *	19,50 (4,47)	18,4 (4,64)	18,95 (4,55)
OQ 45.2 Global Index *	92,37 (11,01)	96,47 (10,22)	94,42 (10,73)
Number of weekly binge episodes *	2,83 (0,74)	2,8 (0,8)	2,82 (0,77)

Data are given as mean (SD).

Table 2

Differences Between CBT and BST Groups Considering Primary Outcome Measure (Change in the Global Index and Other Sub-Indexes of the OQ 45.2) and Secondary Outcome Measures (Percentage of BED Patients Remitted Considering the Number of Weekly Binge Episodes and the Weight Loss) at Discharge from the Hospital and After 6 Months

							95% CI
Outcomes (Primary and Secondaries)		N	Mean	s.d.	p	Effect size (Hedges)	Lower Bound	Upper Bound
OQ 45.2 Symptom Distress (SD) change from Baseline to Discharge	CBT	30	-2,7	3,49	0,556	-0,15	-0,66	0,36
	BST	30	-3,2	3,04
OQ 45.2 Symptom Distress (SD) change from Discharge to 6 months	CBT	30	-7,93	5,12	0,000	-1,09	-1,64	-0,55
	BST	30	-14,1	5,98
OQ 45.2 Interpersonal Relations (IR) change from Baseline to Discharge	CBT	30	-1,5	6,67	0,114	-0,41	-0,92	0,10
	BST	30	-4,5	7,78
OQ 45.2 Interpersonal Relations (IR) change from Discharge to 6 months	CBT	30	-2,2	10,3	0,408	-0,21	-0,72	0,29
	BST	30	-4,47	10,78
OQ 45.2 Social Role (SR) change from Baseline to Discharge	CBT	30	-1,77	2,11	0,920	0,03	-0,48	0,53
	BST	30	-1,7	2,93
OQ 45.2 Social Role (SR) change from Discharge to 6 months	CBT	30	-4,33	2,93	0,205	-0,33	-0,84	0,18
	BST	30	-5,57	4,38
OQ 45.2 Global Index change from Baseline to Discharge	CBT	30	-5,97	6,2	0,570	-0,49	-1,01	0,02
	BST	30	-9,4	7,46
OQ 45.2 Global Index change from Discharge to 6 months	CBT	30	-14,47	12,07	0,000	-1,09	-1,63	-0,55
	BST	30	-27,2	10,91
Percentage of Weight loss from Baseline to Discharge	CBT	30	-6,3	2,36	0,152	-0,37	-0,88	0,14
	BST	30	-7,12	2,02
Percentage of Weight loss from Baseline to 6 months	CBT	30	-11,92	16,9	0,128	-0,39	-0,90	0,12
	BST	30	-16,93	5,51
Percentage of Weight loss from Discharge to 6 months	CBT	30	-5,96	17,90	0,191	-0,34	-0,85	0,17
	BST	30	-10,53	6,14

Table 3

Within-Group Changes of Primary Outcome Measure (OQ 45.2 Global Index) and Secondary Outcome Measures (OQ 45.2 Sub-Indexes and Weight Loss) at Discharge from the Hospital and after 6 Months by Treatment Group (CBT and BST)

					95% Confidence Interval of the Difference
Outcomes (Primary and Secondaries)	Group	N	Mean	Std. Deviation	Lower Bound	Upper Bound
OQ 45.2 Symptom Distress (SD) change from Baseline to Discharge	CBT	30	-2,7	3,49	-3,95	-1,45
	BST	30	-3,2	3,04	-4,29	-2,11
OQ 45.2 Symptom Distress (SD) change from Discharge to 6 months	CBT	30	-7,93	5,12	-9,77	-6,10
	BST	30	-14,1	5,98	-16,24	-11,96
OQ 45.2 Interpersonal Relations (IR) change from Baseline to Discharge	CBT	30	-1,5	6,67	-3,89	0,89
	BST	30	-4,5	7,78	-7,29	-1,71
OQ 45.2 Interpersonal Relations (IR) change from Discharge to 6 months	CBT	30	-2,2	10,3	-5,89	1,49
	BST	30	-4,47	10,78	-8,32	-0,61
OQ 45.2 Social Role (SR) change from Baseline to Discharge	CBT	30	-1,77	2,11	-2,52	-1,01
	BST	30	-1,7	2,93	-2,75	-0,65
OQ 45.2 Social Role (SR) change from Discharge to 6 months	CBT	30	-4,33	2,93	-5,38	-3,29
	BST	30	-5,57	4,38	-7,13	-4,00
OQ 45.2 Global Index change from Baseline to Discharge	CBT	30	-5,97	6,2	-8,19	-3,75
	BST	30	-9,4	7,46	-12,07	-6,73
OQ 45.2 Global Index change from Discharge to 6 months	CBT	30	-14,47	12,07	-18,79	-10,15
	BST	30	-27,2	10,91	-31,10	-23,30
Percentage of Weight loss (change) from Baseline to Discharge	CBT	30	-6,3	2,36	-7,14	-5,45
	BST	30	-7,12	2,02	-7,85	-6,40
Percentage of Weight loss (change) from Baseline to 6 months	CBT	30	-11,92	16,9	-17,97	-5,87
	BST	30	-16,93	5,51	-18,91	-14,96
Percentage of Weight loss (change) from Discharge to 6 months	CBT	30	-5,96	17,9	-12,36	0,45
	BST	30	-10,53	6,14	-12,73	-8,33