| Literature DB >> 2155813 |
S Oka1, K Ogino, T Hobara, S Yoshimura, H Yanai, Y Okazaki, T Takemoto, H Ishiyama, T Imaizumi, K Yamasaki.
Abstract
Diethyldithiocarbamate, an inhibitor of Cu,Zn-superoxide dismutase, was recently found to be ulcerogenic in the rat stomach, and active oxygen species were found to be responsible for its ulcerogenicity. To clarify which active oxygen species play a role in ulcerogenesis, the effects of various scavengers and iron-chelators were studied. As superoxide dismutase and catalase reduced the ulcerogenesis induced by diethyldithiocarbamate, the superoxide radical and hydrogen peroxide were considered to play a pathogenic role in this ulcer model.Entities:
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Year: 1990 PMID： 2155813 DOI： 10.1007/BF01951766
Source DB: PubMed Journal: Experientia ISSN： 0014-4754