| Literature DB >> 2155795 |
R A Morrisett1, A H Rezvani, D Overstreet, D S Janowsky, W A Wilson, H S Swartzwelder.
Abstract
The ability of MK-801, an N-methyl-D-aspartate (NMDA)-channel antagonist, to suppress alcohol withdrawal seizures generated audio-genically was studied in adult male rats using a cross-over experimental design. MK-801 treatment reduced overall seizure score and proportion of rats seizing. In comparison to other seizure models, alcohol withdrawal seizures seem to be particularly sensitive to MK-801, suggesting that mechanisms which result in seizure susceptibility after withdrawal of chronic ethanol exposure may be dependent upon sensitization or upregulation of NMDA processes.Entities:
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Year: 1990 PMID： 2155795 DOI： 10.1016/0014-2999(90)90138-v
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432